Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of a 47-year-old man with choriocarcinoma is reported. This case is quite unique in that the primary tumor presented in the submental region. Multiple remote metastases developed within a few weeks after the tumor extirpation, resulting in a fatal outcome. The neoplasm revealed the features of pure choriocarcinoma. By the immunoperoxidase method, it was demonstrated that both cyto- and syncytiotrophoblasts produced HCG.
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PMID:Primary nongestational choriocarcinoma of submental region. 654 16

The level of serum TPA was determined by radio-immunoassay in 19 healthy subjects and 90 patients with urogenital cancer. The normal level of serum TPA was 86 +/- 24 U/l, and the level of more than 134 U/l was determined positive. The positive rate of TPA was 38.9% in 90 patients, while that of CEA was 25.6%. In 19 patients with bladder tumor and 7 with testicular tumor, the positive rates of TPA were 52.6% and 71.4%, respectively, and the level of serum TPA was high in these positive patients. Considering the low positive rate of CEA, TPA may be a more useful marker than CEA in patients with bladder tumor and testicular tumor. Serial determinations of serum TPA and CEA showed the considerable variation of serum TPA compared with serum CEA and a temporary elevation of serum TPA following radical nephrectomy and retroperitoneal lymphadenectomy. However, the level of serum TPA fell significantly after the successful treatment in 8 patients (2 with renal cell cancer, 3 with bladder tumor, 1 with prostate cancer, 2 with testicular tumor) and rose sharply with recurrent or metastatic disease in 4 patients (2 with bladder tumor, 2 with testicular tumor). Although there was no correlation between the levels of serum TPA and serum PAP, the level of serum TPA tended to change in parallel with the level of serum AFP or HCG in 3 patients with testicular tumor.
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PMID:[Evaluation of serum tissue polypeptide antigen (TPA) in patients with urogenital cancer]. 672 13

Primary malignant germ cell tumors of the mediastinum are extremely rare among females. This report describes such a tumor arising in the mediastinum of a 26-year-old woman and correlates immunohistochemical studies of the neoplasm with serum tumor markers. Microscopic examination of the tumor revealed an embryonal carcinoma with choriocarcinoma, the latter consisting of sheets of polygonal cells intimately related to multinucleate giant cells that contained beta-human chorionic gonadotropin (beta-HCG) when stained immunohistochemically. The serum beta-HCG level at the time of diagnosis was 8,300 mU/ml and remained elevated throughout the patient's course. Alpha-fetoprotein was not detected in serum or tissue. Postoperative chemotherapy failed to control the growth of the tumor, and the patient died as a result of massive intrathoracic tumor involvement. At autopsy, metastases were found in two periaortic lymph nodes and in the liver. There was no gross or microscopic evidence of ovarian disease. This case illustrates the typical behavior of malignant germ cell tumors of the mediastinum, rare among females and infrequently described in the literature. To our knowledge, this is the first detailed immunohistochemical study of a mediastinal germ cell tumor in a female.
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PMID:Primary embryonal-choriocarcinoma of the mediastinum in a woman. A case report with immunohistochemical study. 701 70

In 24 of 43 patients (56%) with malignant germ cell tumors of the testis, the serum was positive for HCG prior to ablation of the testis. We give a detailed account of the course of HCG levels in the serum of 7 patients with seminoma of the testis. Positive serum-HCG-findings 8 to 10 days after semi-castration and prior to retroperitoneal lymphadenectomy indicate tumor metastases. In two thirds of our patients, we observed a correlation between regression of metastases under chemotherapy and the pattern of serum-HCG-levels.
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PMID:[Value of beta-HCG blood levels in patients with malignant tumors of the testis]. 702 85

A retrospective study has been carried out on the poor prognostic features of a group of 57 patients. These are: the existence of extra-pelvic and extra-pulmonary metastases and a level of serum HCG above 200000. The most favourable prognostic signs are absence of these two factors in pregnancy that is not normal and a delay between the onset of the first diagnostic elements and treatment of less than 6 months.
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PMID:[Factors of severity in placental choriocarcinoma]. 714 70

Observation of 24 gestational trophoblastic tumors, i.e. 20 hydatidiform moles, 1 invasive hydatidiform mole, 1 non-metastatic and 2 metastatic choriocarcinomas, is reported. The diagnoses were based on case record data, clinical findings, echography and radioimmunoassay of human gonadotropin (HCG). The therapy was oriented towards maintaining fertility in reproductive women. For treatment with cytostatic drugs the patients were allocated to a low risk and a high risk group according to history, diagnosis and former therapy, and an appropriate mono- or combined therapy was started. 17 of 24 patients were cured by surgery in an initial therapy phase. 7 tumors were progressive, 6 of which responded to secondary surgical or cytostatic treatment. One patient died from metastases of choriocarcinoma. The total cure rate of 96% was rendered possible by regular follow-up including bimanual palpation, echography, HCG-assay and chest X-rays.
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PMID:[Current diagnosis and therapy of gestational trophoblastic tumors: experience with 24 patients]. 719 49

The first case of placental choriocarcinoma producing clinical hyperthyroidism reported in France is described. Recovery occurred, with disappearance of the choriocarcinoma metastases and hyperthyroidism signs, after chemotherapy alone (vincristine and methotrexate). A review of the seven cases reported in the published literature showed that the hyperthyroidism could be related to the thyroid-stimulating activity of the tumoral gonadotropin (HCG).
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PMID:[Hyperthyroidism from placental choriocarcinoma: a case report and review of the literature (author's transl)]. 742 47

The biopsies from 75 patients with transitional cell carcinoma of the bladder (25 Ta-T1; 45 T2-T4, 5M) were studied immunohistochemically for the expression of beta-human chorionic gonadotrophin (beta-HCG). Only 5 Ta-T1 tumours contained a small number of beta-HCG positive cells but 24 invasive tumours and all patients with metastases showed increased numbers of positive cells. A significant correlation was found between beta-HCG immunoreactivity and tumour category. In 30 patients with muscle-invasive disease (T2-T4,N0,M0) who were treated with radical radiotherapy a significant correlation was observed between response to treatment and beta-HCG expression; beta-HCG positive tumours did not respond to treatment. A difference in survival was found between patients with tumours negative for beta-HCG compared with patients with positive tumours, all treated with radical radiotherapy. The results indicate that beta-HCG expression increases with tumour invasiveness and the use of immunohistochemistry may prove a useful means of identifying radioresistant and aggressive forms of bladder cancer.
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PMID:Is beta-human chorionic gonadotrophin production by transitional cell carcinoma of the bladder a marker of aggressive disease and resistance to radiotherapy? 750 30

Alfa-fetoprotein (AFP) is an indispensable examination in the management of non-seminomatous germ cell tumor. However, many liver diseases also frequently show the elevation of AFP. Therefore, it is essential to discriminate between yolk sac-derived component and liver-derived one. A 32-year-old male who had suffered from chronic hepatitis, visited our clinic in December, 1991. He complained of left scrotal atrophy and dull pain. Surgical specimen was histologically diagnosed as embryonal carcinoma with syncytiotrophoblastic giant cell. The levels of tumor markers, such as AFP, beta-human chorionic gonadotropin (beta-HCG), were estimated. Both of them were elevated, and radiographical studies demonstrated metastatic lesions of bilateral lung field and retroperitoneal lymph nodes (RPLN). After three courses of cisplatin based chemotherapy, lung and RPLN metastases diminished and serum beta-HCG had normalized. However, the serum AFP persisted to show an abnormally high concentration. The subfraction profile with lens culinaris hemagglutinin (LCA) was estimated. The one after the first course was compared with the one after third course. The latter one showed complete diminution of peak 2. This implied the diminishment of yolk sac element.
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PMID:[A case of nonseminomatous germ cell tumor: usefulness of alphafetoprotein subfraction]. 751 45

The cardinal syndrome of a testicular germ cell tumour is typically scrotal enlargement. The present paper compares the group of patients with typical scrotal presentation and those who present with atypical symptoms caused by metastases. Among 284 retrospectively studied patients, 34 (12%) presented with extrascrotal symptoms. The most important were abdominal pain (n = 16) and pulmonary symptoms (n = 10). The group of patients with extrascrotal symptoms was characterized by the following parameters: percentage of pure seminoma in 35% (versus 56% in the patients with typical presentation), elevation of alpha-feto-protein in 47% (versus 27%), and elevation of beta-HCG in 61% (versus 29%). The outcome was lethal in 35% of the patients with atypical presentation, as opposed to 6% of those with typical presentation. In 22 patients with extrascrotal presenting signs a palpable testicular mass was found on clinical examination. Occult testicular tumour proved to be present in 9 patients, and burned-out tumours in 3. Unawareness of testicular cancer is a significant factor in diagnostic delay. Scrotal palpation should be part of every clinical examination in younger male patients with cancer from an unknown primary.
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PMID:[Atypical symptoms in patients with germinal testicular tumors]. 752 31


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