Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Primary Thyroid Lymphoma (PTL) is lymphomatous process involving the thyroid gland without contiguous spread or distant metastases from other areas of involvement at diagnosis. It is a rare tumor usually presenting in 60s with rapidly enlarging thyroid mass. Proper evaluation of FNAC specimens is essential in diagnosis as they may be confused with Hashimoto's Thyroiditis or Anaplastic Carcinomas. With the advent of rituximab (monoclonal antibodies binding B-lymphocytes), chemotherapy is the mainstay therapy- CHOP + rituximab. However, there may still be some role of local therapies. We present here two cases which had presented at our OPD in last year. Both our patients had presented with rapidly enlarging neck masses with compressive features. Both were reported as Hashimoto's Thyroiditis on initial FNAC. Both underwent thyroidectomy followed by chemotherapy with CHOP + rituximab and are now doing well with no recurrence till date.
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PMID:Primary thyroid lymphoma: a series of two cases and review of literature. 2477 59