Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Recent advances, particularly in the fields of biology and nuclear medicine, have improved our understanding of carcinoma of the prostate and, thereby, have contributed to a more precise application of the different therapeutic approaches currently available. Although cytology and "immunological" assay of prostate phosphatases have not replaced rectal examinations in the diagnosis of this condition, it is now possible to assess its stage and "aggressivity" very accurately. Staging the disease demands exhaustive investigation, especially when the cancer is small; although blood-born metastases can be rapidly demonstrated, it is much more difficult to affirm the localised, purely intracapsular form of epithelioma; lymphography and surgical "picking" of lymph nodes should be considered in some cases. The stage and evolution of the cancer, and the general condition of the patient may indicate therapeutic abstention, palliative treatment (hormone therapy) and, all too rarely, an attempt at radical surgical care. There are a number of therapeutic choices of sometimes surprising, sometimes disappointing efficacy, especially in cases "escaping" oestrogen control, heralded by a rise in phosphatase levels.
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PMID:[Prostatic cancer: what is new?]. 666 42

Lung function was studied in 29 children suffering from extrapulmonary tumors of varying etiology (Wilm's tumor, n = 7; bone malignancy, n = 17; nasopharyngeal epithelioma, n = 5). Lung volume: vital capacity (VC) and functional residual capacity (FRC), lung mechanics: lung resistance (RL), dynamic lung compliance (CLdyn) and static lung compliance (CLstat) and lung transfer factor for CO (TLCO), and blood gases were determined at different stages of therapy: at t0, before any aggressive treatment for respiratory function; at t1, after the initiation of polychemotherapy with or without local tumoral treatment (surgery or local irradiation); at t2, less than 6 months after onset of thoracopulmonary irradiation (whole lung irradiation at 20 grays) (group I), or local thoracopulmonary irradiation at high exposure greater than 40 grays (group II); at t3 after more than 6 months following irradiation with chemotherapy maintained; at t4, after cessation of all treatment (mean: 25 months +/- 14 after cessation of treatment). At t0, lung function data in children without pulmonary metastases did not deviate from predicted values. At t1, group I showed a significant decrease in CLdyn, which could be due to chemotherapy and for 5 children to consequences of abdominal surgery. In group II, only two children had a low CLdyn and also a significant decrease in VC (possibly due to the site of the tumor). After irradiation (at t2), FRC, TLCO and CLdyn were significantly lower than the predicted values and lower than at t1 in both groups (p greater than 0.01). At t3, functional parameters did not show any change compared to t2. At t4, FRC and TLCO were within normal limits in both groups but CLdyn, CLstat and the CLdyn/FRC ratio remained significantly decreased. It is suggested that these functional abnormalities are due to inadequate alveolar growth.
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PMID:Lung function of children treated for malignant extrapulmonary tumors. 672 61

In two cases of epithelioma cuniculatum, a rather rare form of verrucous carcinoma of the plantar surface of the foot, the lesions were excised by means of microscopically controlled surgery (Mohs' chemosurgery) with successful results, both clinically and cosmetically. Although the tumor is generally slow-growing and often mistaken for a plantar wart, it can cause extensive local destruction. Metastasis has been reported and may be related to anaplastic transformation caused by radiotherapy. In certain cases, amputation may possibly be avoided through the use of microscopically controlled surgery.
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PMID:Microscopically controlled surgery (Mohs' chemosurgery) for treatment of verrucous squamous cell carcinoma of the foot (epithelioma cuniculatum). 683 35

Inhibition of subcutaneous tumour growth, following treatment with tilorone hydrochloride, was observed with two transplantable methylcholanthrene-induced rat sarcomas (Mc7, Mc4), but similar drug treatment was ineffective against two rat hepatomas induced by dimethylaminoazobenzene (D23, D30). Successful therapy of sarcoma Mc7 and Mc4 subcutaneous growth was not accompanied by the development of specific antitumour immunity, although with hepatoma D30, which grew out following tilorone hydrochloride treatment, specific immunity was demonstrated, indicating that drug treatment does not prevent the initiation of an antitumour response during progressive tumour development. Under defined experimental conditions tilorone hydrochloride also prevented pulmonary metastases from a subcutaneous tumour graft of epithelioma SP1 and mammary carcinoma SP22, as measured by an increased survival or treated rats.
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PMID:Antitumour effects of tilorone hydrochloride on the in vivo growth of chemically induced and spontaneously arising rat tumours. 721 4

The authors describe a case of inferior red nucleus syndrome due to a solitary intramesencephalic metastasis from a glandular epithelioma of the prostate. They emphasize the rarity of cerebral metastases of prostatic origin, particularly at the level of the brain stem, and the exceptional features of a red nucleus syndrome originating from a tumour.
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PMID:Inferior red nucleus syndrome (Benedikt's syndrome) due to a single intramesencephalic metastasis from a prostatic carcinoma. Case report. 724 82

This report deals with a basal cell epithelioma, partially adenoid and partially morphea-like in structure, which despite intensive X-ray treatment relapsed constantly and which finally developed into an ulcus terebrans. Approximately 13 years after the primary tumor had developed (located on the left wing of the nose) both a lymphogenic and a hematogenic formation of metastases occurred with a subsequent exitus letalis 4 months later. Besides the metastases of the skin, there were multiple metastases in the lymph nodes, vertebral column, ribs, spleen, liver stomach, pleura, and peritoneum as well as in the mycardium of both ventricles and in the perimysium of the skeletal muscles. Their histological structure was similar to a partly adenoid, partly morphea-like basal cell epithelioma. The possible influence of X-ray treatment on the tumor tissue in way of benignity or malignancy is discussed in view of relevant literature of this topic. The alterations of basal cell epitheliomas into the so called transitional epitheliomas in also analyzed.
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PMID:[Basal cell epithelioma with lymphogenic and hematogenic formation of metastases (a.o. into the myocardium) (author's transl)]. 727 14

Exophytic neoplasms arise rarely in neurotrophic ulcers of leprosy. When such a lesion does develop, it has clinical resemblance to an indolent and locally invasive epithelioma cuniculatum, may invade deeply, and may metastasize. The case described showed deep invasion and extensive involvement of bone. Exophytic neoplasms in neurotrophic ulcers of leprosy should be considered to be squamous-cell carcinomas, not epitheliomata cuniculata, because of their potential for rapid, deep invasion and metastases.
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PMID:Squamous-cell carcinoma arising in a leprous neurotrophic ulcer: report of a case. 741 Jun 87

The Torre or Muir-Torre syndrome consists of certain types of sebaceous neoplasms of the skin, with or without keratoacanthomas, and one or more low-grade visceral malignancies in the absence of other predisposing factors. The sebaceous tumors are relatively uncommon or rare: sebaceous adenoma, sebaceous epithelioma, basal cell epithelioma with sebaceous differentiation, and sebaceous carcinoma. Sebaceous hyperplasia and hamartomas such as nevus sebaceus of Jadassohn, with or without a sebaceous epithelioma within it, are not a defining part of this syndrome. Sebaceous hyperplasia is common in elderly light-complexioned people with or without this syndrome. Nevus sebaceus of Jadassohn is not rare and is predisposed to the development of other neoplasms within it, including occasionally a sebaceous epithelioma. Colonic polyps are frequently present. Muir-Torre syndrome requires recognition because affected patients are at risk of multiple primary malignancies. The skin lesions may be the first sign of this syndrome, although more often its cutaneous signs follow the diagnosis of at least the first visceral malignancy. The Muir-Torre syndrome portends the greater possibility of a favorable prognosis than might be anticipated otherwise because the visceral cancers are usually low-grade malignancies. However, they are often multiple, so identifying such patients will affect their management in a few ways. Because these indolent visceral malignancies tend to permit prolonged survival, even metastatic disease may respond well to aggressive surgical treatment. The sebaceous cancers in this syndrome, like the visceral malignancies, are less aggressive than their counterparts unassociated with this syndrome. Because this syndrome is inherited in an autosomal dominant manner, identifying one patient means delineating an entire family, which should be investigated. This syndrome may be caused by a defective mismatch DNA repair gene.
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PMID:The Muir-Torre syndrome: a 25-year retrospect. 878 1

In a period of 6 years the authors had 615 patients with epitheliomas. Squamous cell carcinoma (SCC) was found in 22 of them, meta-typical carcinoma in 2, and basal cell carcinoma (BCC) in the remaining cases. The frequency of application and comparative efficacy of various methods of treatment were appraised. The surgical method was used most frequently--in 84.2% of patients. Cryodestruction prevailed (46.3%) among the surgical methods of epithelioma treatment. Its early results in BCC were favorable in 97% of cases. The frequency of recurrences and metastases was 0.5%. Surgical excision, applied in 31% of patients, was effective in all cases of BCC. In SCC surgical excision is performed in a complex with radiotherapy. The efficacy of combined treatment (surgery + radiotherapy) was about 100%. Generalization of the process was found in only one patient. The other methods of treatment are used much less frequently.
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PMID:[Treatment of epitheliomas]. 800 18

Intraorbital metastases are rare. Tumors that metastasize more frequently in the orbit are: tumors of the breast, thyroid, prostate, spinocellular epithelioma, urinary bladder and Ewing sarcoma with an orbital location. The dominant feature of intraorbital metastases is exophthalmos. Ten cases of intraorbital metastasis are presented, histopathologically confirmed following operation. There are also 3 cases with intraorbital metastases histopathologically nonconfirmed during operation but which were included in a metastatic syndrome.
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PMID:Intraorbital metastases. 803 99


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