Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Verrucous carcinoma of the penis (Buschke-Lowenstein tumor, giant condyloma accuminatum) is a common clearly defined variant of epidermoid carcinoma which features relentless local growth and little tendency to metastasize. Two cases successfully treated by liquid nitrogen cryosurgery are presented herein.
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PMID:Cryosurgery of verrucous carcinoma of the penis (Buschke-Lowenstein tumor). 47 77

The Buschke-Lowenstein tumour of the penis is a rare neoplasm of probable viral origin. It is locally destructive but does not appear to metastasize. The three cases reported illustrate the clinical features and the surgical treatment.
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PMID:The Buschke-Lowenstein tumour or verrucous carcinoma of the penis. 347 11

Verrucous carcinoma of the penis (Buschke-Lowenstein tumor) is a rare variant of squamous cell carcinoma which has been reported to have limited potential for metastatic disease. We report on 2 patients who presented with locally advanced disease after prolonged intervals of neglect. In both cases, the disease was locally aggressive with extensive tissue destruction. In 1 patient, after failure to achieve tumor control with repeated aggressive surgical excision, systemic chemotherapy using bleomycin, cisplatin, methotrexate, and leucovorin led to a complete pathologic response. We believe this is the first reported case in which systemic chemotherapy has been used to successfully treat verrucous carcinoma of the penis. Surgical excision alone was successful in achieving local disease control in the second patient.
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PMID:Buschke-Lowenstein tumor: therapeutic options including systemic chemotherapy. 823 9

Giant condyloma acuminatum is a large, exophytic, cauliflower-like lesion that usually affects the anogenital region. Localisation in the rectum is uncommon and has a high rate of malignant transformation but does not lead to develop distant metastases. For the time, we report the endosonographic appearance of a malignant intrarectal giant condyloma acuminatum.
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PMID:[EUS results of malignant rectal giant condyloma acuminatum (Buschke-Loewenstein tumor)]. 1564 41