Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cryosurgical resection of pulmonary metastases was performed in 112 patients from 1973 to 1993. The cumulative 1, 3, 5, 10 year survival rate was 80.37%, 41.81%, 28.01% and 17.28%. One patient died of respiratory failure after operation. Thirty-day mortality rate was 0.89%. The disease-free interval (DFI) between the control of primary tumor and appearance of metastases was significantly correlated with post-thoracotomy survival. The multiple factor analysis also demonstrated that DFI was the most important prognostic factor for patients after cryosurgical resection of pulmonary metastatic lesions. The overall 5 year survival rate of patients treated with cryosurgery in our report was higher than that of those treated by local resection of pulmonary metastases reported by other authors. Our results indicated that cryosurgical resection of pulmonary metastases was effective and safe, the survival time of most patients could be prolonged and some patients could be cured.
 ...
PMID:[Cryosurgical resection of pulmonary metastases (experience of twenty years)]. 873 5

Hemothorax can be caused by rupture of hepatocellular carcinoma (HCC). Hemoperitoneum is a well-known cause of death caused by rupture of a primary HCC lesion. Rupture of a HCC metastasis has not been adequately described. This is the first report of a HCC patient who died of hemothorax due to rupture of a pleural metastasis. The patient, a woman, died in respiratory failure 2 wk after rupture of her HCC metastasis in the pleura. Autopsy revealed moderately differentiated HCC in the liver, lung, and pleura. We discuss treatment options for ruptured pleura-based HCC metastases.
 ...
PMID:Hepatocellular carcinoma with pleural metastasis complicated by hemothorax. 879 22

We herein report two cases of metastatic lung cancer examined with bronchoscopic cytology. The first case involved a 43-year-old female, who had undergone low anterior resection of the rectum for rectal cancer three years earlier. Routine chest X-ray showed a nodular lesion in the left upper area. Bronchoscopic examination revealed a mass occluding the left upper bronchus. Simultaneous bronchoscopic biopsy and washing cytology were performed. The cytological specimen consisted of cell clusters with tall columnar epithelium arranged in a palisading manner. The cytological findings strongly suggested metastatic adenocarcinoma originating from the colorectal region. The patient died from respiratory failure. Autopsy confirmed metastatic deposit of adenocarcinoma in the lung. Histologically, the tumor invaded the overlying bronchial wall and was exposed in the lumen. The second case was an 80-year-old female, who had been diagnosed as gastric cancer by the endoscopic examination one year earlier. She had refused surgical treatment. Routine chest X-ray showed reticulonodular lesions disseminated throughout the bilateral lungs. Bronchial endoscopy presented edematous mucosa of the right lower bronchus. Brushing cytology as well as punch biopsy were taken. Cytological examination revealed atypical cells with increased N/C ratio and reduced cohesiveness. The lesion was diagnosed as metastatic adenocarcinoma of gastric origin from cytological findings and clinical history. The patient died from respiratory failure. Postmortem examination revealed cancer cells in the lymphatic channels of the bronchial wall. Our two cases indicate that bronchoscopic cytology is useful for estimating the origin of metastatic cancer.
 ...
PMID:[Two cases of metastatic lung cancer examined by bronchoscopic cytology]. 884 24

Carcinoma of the adrenal cortex is a fairly rare entity, usually with a somber prognosis. The efficacy of treatment depends on early prognosis. We are reporting here a case of carcinoma of the adrenal cortex producing androgens, estrogens and cortisol, in which diagnosis was not achieved until two years after the onset of symptoms. Morphologic studies by CT showed local extension and metastases. After mass-reduction surgery, the patient died due to respiratory failure. This case remarks the importance of early diagnosis in this syndrome.
 ...
PMID:[An adrenal carcinoma producing androgens, estrogens and cortisol]. 918 16

A 74-year-old man was admitted to our hospital with a cough. His chest X-ray film, chest CT scan and MRI showed a tumor of the chest wall. Histology of a percutaneous needle biopsy revealed malignant fibrous histiocytoma (MFH). The tumor enlarged rapidly, and the patient underwent resection including the 6th, 7th and 8th ribs and partial resection of the right diaphragm and the right middle and lower lung lobes. Multiple pulmonary metastases were found 40 days after the operation, and the patient died of respiratory failure 4 months after surgery. Although MFH is one of the most common soft tissue sarcomas, lesions arising from the chest wall are uncommon. We stress the need for early diagnosis and aggressive surgical resection in the treatment of MFH arising from the chest wall.
 ...
PMID:[Malignant fibrous histiocytoma of the chest wall: a case report]. 925 46

A case of multicentric gastrointestinal angiosarcoma suffering from severe melena is presented. Endoscopical examination revealed two polyps in the stomach and duodenum. Histological examination showed angiosarcoma. Although a gastroduodenectomy was performed, severe melena continued, and the patient developed respiratory failure and died. At autopsy, multiple hemorrhagic tumors were present from the duodenum to the cecum. Histologically the tumors demonstrated vasoformative structure and were immunohistochemically positive for von Willebrand factor (factor VIII related antigen), CD34, and CD31. Numerous metastases were found in various organs, including the lungs, bones, liver, gall-bladder, and lymph nodes. The patient had received hemodialysis for 21 years due to chronic renal failure. Long-term dialysis had been associated with various malignancies. Multicentric development of angiosarcoma in the present case may also be related to long-term dialysis.
 ...
PMID:Multicentric angiosarcoma of the gastrointestinal tract. 929 36

Severe pulmonary hypertension due to tumor cell microemboli or lymphangitic carcinomatosis is a rare complication of malignant disease. In most of the reported cases, a clinical picture of subacute cor pulmonale developed. A 57-year-old man with deep vein thrombosis in his left calf developed acute progressive dyspnea with hypoxemia, cyanosis and the clinical picture of acute cor pulmonale, while he was on full heparinization. Respiratory failure with the need for mechanical ventilatory support developed within 2 days. Chest radiography revealed the development of acute cardiac enlargement, dilated pulmonary artery and diffuse opacities in the fields of both lungs. Open lung biopsy disclosed massive tumor cell microemboli and lymphangitic carcinomatosis. No parenchymal metastases were found. This case is extremely rare because of the rapid development of the patient's respiratory signs and symptoms of acute cor pulmonale due to pulmonary tumor cell microemboli and lymphangitic carcinomatosis. It is also most atypical because of the rare pulmonary radiographic presentation.
 ...
PMID:Acute cor pulmonale due to tumor cell microemboli. 931 Oct 58

Forty-six cases of breast cancer, autopsied at the Tokai University Hospital, between 1975 and 1993, were studied. Forty of the patients had undergone surgery, and 27 of them had been surgically treated in the Tokai University Hospital. The major causes of death were respiratory failure, cancer-related complications, and hepatic failure. Frequently involved organs were lymph node, lung, liver, and bone. The survival time after surgery ranged from 1 day to 137 months, with the patients being divided into two groups based on survival of more or less than three years after surgery. Frequently observed in individuals surviving less than 3 years were larger tumor sizes, extensive lymph node metastases, advanced stages, and negative reactions for estrogen and progesterone receptors, as compared to individuals surviving for more than 3 years. The patterns of tumor metastasis were also different in two groups. Local recurrences were more frequently observed in short-term survivors whereas disseminated spreading was encountered in the long-term survivors. These findings seem to indicate that not only survival time but also pattern of recurrence are related to the status of the original tumor.
 ...
PMID:A study of 46 cumulative breast cancer autopsy cases. 960 27

We report a rare case of multiple pulmonary metastases with cavitation from gallbladder cancer. A 77-year-old woman was admitted to our hospital complaining of productive cough and exertional dyspnea. Chest X-ray film showed multiple nodular shadows with some cavitation. Computed tomography showed multiple cavities, up to 2 cm in diameter, as well as nodules, in bilateral lung fields. Under a survey of primary focus, the ultrasonographic test of the abdomen revealed a hypoechoic mass in the hepatic hilum. The patient died of respiratory failure. Autopsy findings revealed that that multiple lung tumors had metastasized from papillary adenocarcinoma of the gallbladder and that cavitation of the lung was formed by bronchioloectasis.
 ...
PMID:Multiple pulmonary metastases with cavitation from gallbladder cancer. 961 65

A 64-year-old man was admitted to our hospital because of abnormal shadows on chest X-ray films. Malignant mesothelioma was suspected. However a CT scan revealed a large mass in the right kidney and many nodules in the liver and pleura. This suggested that primary renal cell carcinoma had metastasized to the liver and pleura. The patient was treated with transarterial embolization (TAE), alpha and gamma interferon, and UFT, but died of respiratory failure caused by massive bleeding from the pleural metastases. At autopsy, renal cell carcinoma, clear cell subtype, was noted. The many pleural lesions were of the same histologic type, which suggested that they were metastases from the kidney. Renal cell carcinoma frequently metastasizes to the lungs or bones via the arteries. However, many pleural metastases without lung metastasis is rare. We report a case of renal cell carcinoma with many pleural metastases via Batson's venous plexus.
 ...
PMID:[Renal cell carcinoma with many transvenous pleural metastases]. 969 52


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>