Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 44-year-old woman presented with a tumorous mass on the right hypochondrium, however, no clear tumor was detected. One year later she was found to have an abdominal tumor. Upon surgery, the abdominal tumor was identified as a pedunculated hepatoma arising from the right hepatic lobe and was resected radically. Two years later, the hepatoma recurred as very rare remote metastases to the lung, brain and gingiva, and the patient died of respiratory failure. Autopsy showed no local recurrence in the liver, but remote metastases were present in the lung, brain and lymph nodes. The gingival tumor had disappeared following irradiation therapy.
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PMID:[A case report of pedunculated hepatoma with very rare remote metastases after the resection]. 632 85

Although basal cell carcinomas are the commonest malignant condition of the skin (Borel 1973) pulmonary metastases are rare; it appears that only 30 authenticated cases have been reported (Sakula 1977). A further case is described of a man aged 64 who presented severe dyspnoea and who for 12 years had harbored an untreated ulcerating lesion of the abdominal wall shown histologically to be a basal cell carcinoma. Chest radiography showed metastatic disease confirmed histologically to be identical to the ulcerating skin lesion. Unfortunately, because of the severe respiratory condition, no definitive treatment was indicated and the patient died of respiratory failure 2 weeks following discharge.
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PMID:Pulmonary metastases from a basal cell carcinoma. 645 28

Malignant melanomas rarely grow in the oral mucosa and few established melanoma cell lines originate from the gingiva. Our patient was a 59-year-old man with a dark mass at the upper incisive gingiva and a large lymphadenopathy in the submandibular region. The gingival biopsy showed malignant melanoma. Because of the marked metastases, he received both chemotherapy and immunotherapy. Although regression and discoloration of the tumors were seen, he died of respiratory failure 9 months after admission. At autopsy, metastatic amelanotic and melanotic melanomas were found in various organs. Cells were obtained for tissue culture from pleural fluids of the patient. Eagle's MEM or RPMI1640 with 20% f.c.s. was used for the culture medium, and cells were found to attach to the bottom of the culture tube and to show no contact inhibition. Electron microscopy of primary cultured cells showed premelanosomes in the cytoplasm. The cells were transplantated into nude mice for studies of tumorgenesis and for serial transplantation of the tumor. A progressive tumor appeared. At present (June 19, 1980), 110 passages have been made and the cells are growing well. They were named HMG.
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PMID:Primary malignant melanoma of the oral cavity. Case report and establishment of melanoma cell line. 680 72

A case of primary osteogenic sarcoma of the skull with metastases to the lungs, left diaphragm, 2nd lumbar and 1st sacral vertebral bodies, and both femoral heads was presented. A young man with a lump over his right parieto-occipital region since the age of 14 had noticed rapid growth of the mass after having experienced definite head trauma. The tumor was surgically removed and the bony defect was repaired with a stainless stell plate. The recurrence of the tumor mass was suppressed by 60Co irradiation, but a necrotic lesion developed over the right temporal scalp. Twenty-two months after the surgical removal of the tumor, the patient died of respiratory failure and septicemia.
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PMID:Primary osteogenic sarcoma of the skull: case report. 694

A 25-year-old patient, with multiple pulmonary metastases from osteogenic sarcoma who two years ago developed respiratory failure with unilateral left lung involvement and was successfully treated with independent lung ventilation, was readmitted to an ICU with recurrent unilateral lung disease. Conventional therapy failed to reverse the respiratory failure; independent ventilation temporarily improved the patient's oxygenation. At autopsy, different involvement of the two lungs by the tumor was evident so that blood flow of the right lung and lymphatic flow of the left lung were impaired. When respiratory failure unresponsive to conventional therapy develops, anatomical abnormalities should be considered.
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PMID:Recurrent unilateral lung disease. 694 82

During the 37 year period between 1943 and 1980, 68 pediatric patients underwent 86 major pulmonary resections during 73 separate operations. The surgical procedures included lobectomy (55), segmentectomy (25), pneumonectomy (three), and cyst excision (three). The 73 operations were performed for nontuberculous infection, congenital malformation, tuberculosis, tumor, obstructive lung disease, cardiac-related problems, immunologic disease, and trauma in decreasing order of frequency. The operative mortality was 4.4%; the disease-relate late mortality was 6.2%, due to either chronic respiratory failure or metastatic disease. Complications occurred in 21.9% of the operations. Only one death occurred during the last two decades, but the morbidity rate remained constant through all decades. Analysis by decade showed a striking change in the spectrum of pediatric pulmonary operations over the 37 year study period. Three major trends were identified: (1) Bronchiectasis and tuberculosis, once the major indications for pulmonary resection, have, from a surgical standpoint, virtually disappeared. (2) Congenital pulmonary anomalies now account for the majority of major pediatric pulmonary resections. As a consequence, the patient age at operation has steadily decreased, and pulmonary resections in infants (under 1 year of age) make up almost half of the surgical resections currently being done. (3) Despite the marked decline in the number of operations performed for infectious pulmonary disease, the total number of pulmonary operations in the pediatric age group has not decreased.
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PMID:The changing spectrum of pulmonary operations in infants and children. 707 37

The case history of a 27 year old male ex-intravenous drug user who presented with haemoptysis and indistinct lung shadowing is reviewed. During a 3 week period of investigation his lung shadowing increased dramatically and it became apparent that he had metastases from chorionic gonadotropin-producing testis cancer which had undergone spontaneous regression of the primary tumour. Unfortunately by the time he was referred for treatment he was in respiratory failure and died 48 hours after treatment started. The critical importance of the urinary pregnancy test (available in most casualty departments to diagnose ectopic pregnancy) in accelerating diagnosis and treatment of such a case is highlighted.
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PMID:Hurricane growth of malignant trophoblastic teratoma. 751 75

A 65-year-old man complaining of a left medial ocular angle mass and hemoptysis was admitted to our hospital. Chest radiography revealed a right hilar mass and bronchoscopy revealed widespread cancerous invasion of the carina, both main bronchi, right upper lobe bronchus, truncus intermedius, and middle lobe bronchus. Histological examination of a biopsied specimen revealed small cell carcinoma. Brain CT scan, abdominal CT scan, and bone scintigram showed solitary brain, multiple liver, and multiple bone metastases. Partial response was obtained with three courses of combined chemotherapy with carboplatin and etoposide, and the ocular tumor until it was almost invisible to the unaided eye. However, complete response could not be obtained with additional two courses of combined chemotherapy, and the patient was discharged. Seven months after the first admission, he was readmitted with dyspnea and an enlarged (6 mm in diameter) left ocular mass. Histological examination of the resected mass revealed a small cell carcinoma that had metastasized to the conjunctival substantia propria. He died of respiratory failure one month after readmission. Metastasis to the eye from primary lung cancer is uncommon and patients such as this are extremely rare. Although some cases of uveal or orbital metastasis from lung cancer have been reported, we can find no other report of conjunctival metastasis from lung cancer.
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PMID:[Small cell lung cancer presenting as a metastatic conjunctival tumor]. 781 69

A 67-year-old woman with bloody stool was admitted to our hospital. Chest radiograph on admission showed a tumor shadow in the right lower lung field. Lung adenocarcinoma of right S6 and villous adenoma of the rectum were detected. Although she was treated with chemotherapy and radiotherapy, she died of respiratory failure. At autopsy, moderately differentiated adenocarcinoma of the right lung, renal cell carcinoma, and villous adenoma of the rectum were confirmed. Lung adenocarcinomas were detected in the focus of the renal cell carcinoma and in the villous adenoma. Metastasis of a cancer into another coexisting tumor in the same individual is extremely rare, and a satisfactory explanation for this phenomenon has not yet been offered.
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PMID:[An autopsy case of lung cancer metastasizing to renal cell cancer and rectal villous adenoma]. 785 80

A 63-year-old woman was in hospital for persistent backache. Four months prior to admission she had been pointed out as having hypertension for the first time. On admission, she had anemia (hemoglobin 7.0 g/dl) with reticulocytosis, and a blood smear showed fragmented erythrocytes. A bone marrow aspirate disclosed erythroid hyperplasia and invasion of cancer cells. The chest roentgenogram showed a coin-lesion of the right lung and left pleural effusion. A diagnosis of microangiopathic hemolytic anemia (MAHA) associated with carcinomatosis was made, but the primary site of the cancer was unknown. Respiratory failure developed and the patient died a month later. Surprisingly, the autopsy revealed a malignant pheochromocytoma arising from the right adrenal gland with massive metastases to the lungs, liver, lymph nodes and systemic bones, and also disseminated intravascular coagulation (DIC). The DIC would probably account for the MAHA in this case. To our knowledge, this is the first reported case of malignant pheochromocytoma accompanied by MAHA.
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PMID:Malignant pheochromocytoma accompanied by microangiopathic hemolytic anemia: a case report. 800 27


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