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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Many patients diagnosed with breast cancer will develop metastases and these have diverse presentations. We have reviewed 100 consecutive patients who have died with metastatic breast cancer, to determine the frequency, sites and mode of presentation of recurrent disease. The commonest site of failure was loco-regional (n = 61), this usually presented with a mass, but a minority of patients also complained of pain. Bone metastases developed in 60 patients and produced bone pain, pathological fracture (n = 6) or cord compression (n = 5). Pulmonary metastases producing shortness of breath were diagnosed in 34 patients and were asymptomatic in a further 10. Intra-abdominal metastases were found at some time in 23 patients, most commonly in the liver (n = 20) and the majority complained of epigastric pain (n = 17). Brain metastases occurred in 23 patients and produced a wide range of symptoms including those of a space-occupying lesion (n = 10), cranial nerve palsy (n = 7), diabetes insipidus (n = 3), focal limb weakness (n = 2) and meningitis (n = 1). Three patients had choroid metastases producing reduced visual acuity. Recurrent breast carcinoma can present in a variety of ways, therefore any new symptom or sign should be considered to represent recurrence until proved otherwise.
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PMID:Patterns of clinical metastasis in breast cancer: an analysis of 100 patients. 863 4

The aim of this study was to evaluate the incidence of tumor cell dissemination after saline infusion sonohysterography (SIS) in patients with endometrial cancer (EC). A retrospective study was conducted on 173 patients with EC in whom one of the following methods were performed: dilation and curettage (D&C, n = 120) and D&C followed by SIS (n = 53). No selection or randomization of patients was applied to both groups. The presence of positive peritoneal cytology, as well as adnexal or abdominal metastases was considered the endpoint of this analysis. Positive peritoneal cytology was present in one patient (0.8%) after D&C and in one patient (1.9%) after D&C followed by SIS (chi(2) = 0.030; p > 0.05). Adnexal metastases were present in nine (7.5%) patients after D&C and in three (5.7%) patients after D&C followed by SIS (chi(2) = 0.013; p > 0.05). Metastases to abdominal cavity were found in three (2.5%) patients after D&C and in two (3.8%) patients after D&C followed by SIS (chi(2) = 0.001; p > 0.05). Upstaged because of positive cytology, adnexal or abdominal metastases were 13 patients (10.8%) after D&C and six patients (11.3%) after D&C followed by SIS (chi(2) = 0.029; p > 0.05). These data show that SIS does not increase the risk of malignant cell dissemination in patients with EC.
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PMID:Saline infusion sonohysterography and the risk of malignant extrauterine spread in endometrial cancer. 1768 77