Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Results of disease-oriented phase II trials with cis-dichlorodiammineplatinum(II) (cis-platinum) in 135 adequately treated patients with advanced urothelial tumors at Memorial Sloan-Kettering Cancer Center are presented. In four protocols which used cis-platinum alone or in combination with Adriamycin and/or cyclophosphamide in 95 patients with bladder cancer, no significant difference (46%--54%) in the number of partial remissions (PRs) in previously untreated patients was noted. The median duration of response in three of the four protocols was 5--7 months. A review of the literature indicates that cis-platinum used singly produced remissions in 45% of 67 patients (95% confidence limit, 12%--57%). In the treatment of superficial bladder tumors, intravesically administered cis-platinum induced few complete or sustained remissions. The difficulties in evaluating response with intravesical therapy are discussed. The importance of patient selection, particularly the need to include patients with objectively measurable disease parameters, in phase II trials is stressed. Differences in patient characteristics and response criteria will necessitate prospective randomized trials of cis-platinum alone versus cis-platinum combination regimens in the treatment of metastatic disease. cis-Platinum was inactive (12% PRs) in 25 patients with prostatic cancer who had objectively measurable parameters. It is of interest that PRs were obtained in three of six patients (50%) with penile cancer. A review of the literature and the data in the present series indicates that cis-platinum has no value in the treatment of metastatic hypernephroma.
 ...
PMID:Phase II trials with cis-dichlorodiammineplatinum(II) in the treatment of urothelial cancer. 38 26

A 71-year-old woman had massive pulmonary metastases from a right hypernephroma, as shown by a chest roentgenogram. Nine days after nephrectomy, there was no roentgenographic evidence of such metastases. This represents the most rapid regression of clear-cell pulmonary metastases ever reported. Metastases reappeared six months postoperatively and the patient died of widespread metastatic disease 18 months after nephrectomy. The unpredictable behavior of metastatic hypernephroma is discussed.
 ...
PMID:Regression of metastatic hypernephroma. 90 44

On the basis of 4 cases seen by the author and comparative reports in the literature the following observations were made: 1. Clear cell tumors of the lungs must be considered as semimalignant (or malignana). 2. Malignant degeneration may be associated with a loss of the clear cell character. 3. Clear cell areas are not infrequently seen in common pulmonary carcinomas. 4. Histological differentiation between primary clear cell tumors and metastases (e.g., metastatic hypernephroma) may not be possible. In addition, some general observations on extrapulmonary clear cell tumors will be discussed.
 ...
PMID:[Some considerations on clear cell tumors, especially in the lungs (author's transl)]. 122 80

Hypernephroma is one of the most common visceral adenocarcinomas which metastasize to the head and neck. The metastasis may precede discovery of the primary or follow it. The most common sites of metastatic hypernephroma to the head and neck are the sinonasal tract, skin, cervical lymphatics, and mandible. Three cases of metastatic hypernephroma are presented and one of these is the first documented report of a metastasis to the parotid gland. The other two were found in the sinonasal tract.
 ...
PMID:Metastatic hypernephroma to the head and neck. 126 21

Metastatic lesions due to renal cell carcinoma are frequently hypervascular. This study reports the results of preoperative embolization of skeletal metastases from hypernephroma. Reported for the first time in the English literature is the use of this technique for preoperative devascularization of metastatic lesions to the spine in eight patients. Effective devascularization was achieved in all peripheral lesions. Blood loss for peripheral lesions averaged 940 cc and compared favorably to 20 nonembolized cases, in whom average blood loss was 1975 cc. Spinal embolization requires careful identification and preservation of any segmental arteries that supply the anterior spinal artery. Effective spinal devascularization was achieved in six of eight patients. In two patients significant bleeding occurred as a result of incomplete embolization. This series supports the growing evidence for the efficacy and safety of selective arterial embolization in the preoperative control of hemostasis in patients with metastatic hypernephroma. Embolization of spinal metastases, although technically demanding, has been effective in devascularizing these lesions without serious neurologic complications.
 ...
PMID:Preoperative embolization in the treatment of osseous metastases from renal cell carcinoma. 291 Jun 14

Eight cases of metastatic hypernephroma to the head and neck are presented with CT documentation. Hypernephroma is the third most common infraclavicular tumor to metastasize to the head and neck. Such metastases occur in about 15% of patients with this neoplasm, and nearly 8% of patients with this tumor present with disease in the head and neck region. These metastases are usually vascular and may either clinically precede the diagnosis of the renal primary tumor or may occur many years after apparently successful surgery of the primary tumor. These unusual patterns of behavior are reviewed. One of the cases presented here is the first reported incidence of cervical lymph node metastasis with hemorrhage to be documented by CT, thus adding this entity to the list of imaging differential diagnoses of cystic-appearing neck masses.
 ...
PMID:Metastatic hypernephroma to the head and neck. 312 May 36

The findings in aspiration cytology smears from 15 patients with metastatic hypernephroma (renal-cell carcinoma) are presented along with the criteria for cytologic classification of aspirates of primary hypernephroma. The distinctive cytopathology of needle aspirates of metastatic lesions is illustrated. A small nuclear-cytoplasmic ratio was evident in poorly differentiated cells. The cytoplasm was highly characteristic, particularly with Romanovsky stains, and was termed "opaque with or without vacuolization and granulation" to distinguish it from the so-called clear cell of histopathology, which has been denuded of its cytoplasmic content by the histologic process. Cytoplasmic vacuoles were punched out, bubbly or lacy. The partially extruded nucleus was a useful identifying feature. In 7 of the 15 cases, primary hypernephroma was indicated by the cytologic findings in the metastases. This finding may be clinically useful in diagnosing the broad spectrum of obscure paraneoplastic syndromes that may accompany this tumor.
 ...
PMID:Aspiration cytology of metastatic hypernephroma. 658

Clinical signs of hypertrophic osteoarthropathy developed in a thirty-eight-year-old man with metastatic hypernephroma. Roentgenograms of the extremities detected the characteristic periosteal reaction along the radius, ulna, metacarpals, femur, tibia, and fibula, bilaterally. The pathogenesis of this syndrome is unknown; it appears to be mediated by a pathologic reflex with the vagus nerve as the afferent limb. When seen in patients with renal cell carcinoma, hypertrophic osteoarthropathy may herald the development of intrathoracic metastases.
 ...
PMID:Hypertrophic osteoarthropathy in metastatic renal cell carcinoma. 664 41

In 123 cancer patients with metastatic disease, 129 pathologic fractures of long bones were assessed to determine the rate of osseous union. Bony healing was observed in 67% of malignant fractures from multiple myeloma, in 44% of fractures secondary to metastatic hypernephroma, and in 37% of neoplastic fractures from breast carcinoma. No patient with a pathologic fracture secondary to lung carcinoma demonstrated bony repair, and none of these patients lived for more than six months after fracture. The overall fracture healing rate for the entire study population was 35%. In the group that survived longer than six months, 74% of fractures united. A life expectancy of longer than six months was the primary factor determining osseous healing in all patients. A total radiotherapy dose of 3000 rad or less did not inhibit callus formation. Internal fixation improved the rate of fracture union by 23% as compared with cast immobilization.
 ...
PMID:Fracture healing in metastatic bone disease. 688 64

Hypernephroma is one of the most common tumours to spread by extranodal metastases to the head and neck. We herein report on six patients with unusual metastatic hypernephroma to the head and neck area. In two of the six cases, the metastatic tumour in the head and neck was the presenting symptom, and the renal tumour was secondarily detected. Metastatic hypernephroma to the head and neck area has been demonstrated mostly in the paranasal sinuses, parotid gland, and the mandible. Among the six cases presented, four belong to the above-mentioned group, but the other two are rather rare cases, one metastatic to the nasopharynx and soft palate and the other to both lobes of the thyroid gland. Hypernephroma should be sought and excluded whenever a metastatic lesion is encountered in the head and neck area, even if the metastatic lesion is the first clinical presentation. The diagnosis of metastatic hypernephroma should be suspected in any patient with even a remote history of renal cell carcinoma.
 ...
PMID:Metastatic hypernephroma to the head and neck: unusual case reports and review of the literature. 1177 Oct 41


1