Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The results of the surgical management of 28 patients with renal cell carcinoma extending into the inferior vena cava have been analyzed. 8 patients had caval tumor thrombus extension at the level of the renal veins, 14 had infrahepatic, 5 retrohepatic and 1 atrial tumor thrombus extension. The caval wall was infiltrated by tumor in 7 cases. 9 patients had metastases. Lymph node involvement was seen in 9 patients. Life-table analysis of all 28 patients revealed on overall probability of survival of 32 and 9% at 2 and 5 years, respectively. The patients with caval involvement alone (N0M0) had a 2-year survival rate of 69%. Those with distant metastases or caval infiltration had a 2-year survival of 27 and 0% (p = NS). The level of caval tumor thrombus extension had a statistically insignificant influence on the survival of patients. In fact the 2-year survival rates of patients with caval thrombus at the level of the renal veins, below the large hepatic veins and above the large hepatic veins were 30, 36 and 32%, respectively. Our statistical data demonstrate that caval involvement has a very negative impact on the prognosis of patients with renal cancer.
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PMID:Surgical management of renal cell carcinoma with vena cava tumor thrombus. 370 81

Prognostic correlation between the pathologic stage and survival was evaluated in 270 patients with renal cancer treated by enlarged nephrectomy and regional lymphadenectomy. Postoperative mortality varied in proportion to the extent of the tumor: 2.8% for intracapsular cancer, 6.4% for cancers invading perirenal fat, 9.4% for those extending into renal vein, 27.2% for those invading inferior vena cava, 17.4% for those with lymph node invasion and 17.6% for the metastatic tumors operated upon. Overall uncorrected survival was 63.5% at 5 years and 30.9% at 10 years, survival depending therefore on the developmental stage of the cancer. Intracapsular tumor: uncorrected survival at 5 years, 79.7% and at 10 years, 48.8%. For tumors invading perirenal fat without other dissemination: uncorrected survival at 5 years, 70.8% and at 10 years, 16.6%. Tumor extending into renal vein without caval or lymphatic invasion or metastases: uncorrected survival at 5 years, 56.2% and at 10 years, 30%, without any statistical difference from the 2 previous stages. Cancer with inferior vena cava invasion: 11 patients operated, 3 postoperative deaths, 4 metastatic recurrences between 11 and 40 months, and 4 survivors without metastases 6 to 55 months after operation. Cancer with lymphatic dissemination: no survivor in complete remission after 5 years. Cancer with bone or visceral metastases: uncorrected survival at 3 years, 8.3% (single peripheral metastasis irradiated). No operated patient with metastases survived for 5 years. A new classification is proposed: Stage I: intracapsular cancer more or less propagated into the renal vein. Stage II: cancer invading the perirenal fat with more or less propagation into renal vein. Stage III: propagation to the inferior vena cava excluding any lymphatic involvement.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Anatomical classification of adenocarcinomas of the kidney. Reflections apropos of 270 surgically treated cases]. 372 46

In a series of 120 patients presenting a CT image of a cerebral tumor metastasis an analysis of 88 verified cases has been performed aiming at a determination of the morphological criteria which might enable us to speculate on the site of the primary lesion. The following properties have been studied: the location, size and shape of the lesions, their number, the extent of the surrounding edema and their postcontrast enhancement. Lung cancer participated as a source in 30.8% of the disclosed metastases, in 15.8% it was breast cancer, in 11.7% renal cancer, in 9.2% malignant melanoma and the remaining 32.5% were miscellaneous others. Our results demonstrated a certain degree of probability of identifying some of those sources of the CT detected metastases which had hitherto been unknown. Their degree of malignancy might be deduced from their size and shape.
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PMID:CT findings in cerebral metastases. 372 13

Seventeen patients with metastatic renal cancer were treated with human lymphoblastoid cell-derived alpha interferon, 30 X 10(6) U/m2, which was given intravenously for 3 consecutive days of each week for 6 weeks. On the days of interferon treatment only, patients received prednisone, 15 mg t.i.d., in order to minimize toxicity. Of the 16 evaluable patients, one had a minor regression of disease, eight had stable metastatic disease, and seven progressed. Constitutional symptoms, such as fever, anorexia, and fatigue, were common. Debilitating degrees of malaise were a treatment-limiting factor.
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PMID:A phase II trial of high-dose human lymphoblastoid alpha interferon in patients with advanced renal carcinoma. 373 46

Out of 3,340 thyroidectomies (237 for cancer), the authors report 5 cases of thyroid metastases due to clear cell renal cancer. They emphasize the slow development of these metastases. Two cases were operated on 11 years after nephrectomy and one after 27 years. In one case, an intrathyroid metastasis led to the discovery of renal carcinoma. In 3 cases, evolution was rapidly fatal (within the first year). One patient is still alive 6 years after thyroidectomy. The authors emphasize clinical grounds for diagnosis and expose pathology findings that favor longer survival when there is early removal of intrathyroid metastases.
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PMID:[Intrathyroidal metastases of a nephroepithelioma. Reflections on 5 operated cases]. 380 72

Calcitonin and parathyroid hormone concentrations were determined using a radioimmunoassay in the blood serum of lung, breast and kidney cancer patients who had undergone combined treatment for major disease, healthy males, patients with spinal tuberculosis and patients with eosinophilic granuloma of the cranial bones. A significant rise of the calcitonin level and change in the ratio of calcitonin and the parathyroid hormone were established in the blood serum of patients with tumor metastases to the skeleton, spinal tuberculosis and eosinophilic cranial granuloma. During cancer patients' monitoring the determination of calcitonin is recommended as a screening test for skeletal metastases to select patients for gamma-topographic investigation.
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PMID:[Determination of calcitonin and parathyrin in blood serum in the diagnosis of tumor metastases to bone]. 395 20

The paper deals with the data on 1,248 autopsied cases of renal cancer. Metastases were detected in 87.1% (lung--48.2, lymph nodes--43.6, bones and joints--29.1 and liver--28.7%). 90 out of 139 cases of brain metastases died of the lesion. Metastases into the operative scar (most likely, implantation ones) were registered in 8 out of 224 (3.6%) previously nephrectomized cases. In some patients, nephrectomy produced an inhibitory effect on metastatic spread; 13% of the nephrectomized patients survived 5-20 years after surgery.
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PMID:[Metastases of kidney cancer (based on autopsy data)]. 396 47

Bestatin was administered to 20 patients with urogenital tumors. The therapeutic results showed 12 surviving patients and 8 dead patients (including 7 due to cancer and 1 due to a cerebrovascular disorder). One patient has survived for 5 years since bestatin treatment of pulmonary metastasis of renal cancer, and one other patient achieved 5-year survival in spite of systemic metastases of testicular tumor. It is noteworthy that in earlier times these patients could have been expected to experience sudden relapse and aggravation, instead of the long-term survival recorded in this bestatin trial. Studies were conducted on the immunological parameters of the patients before and after the use of bestatin, and it was found that these parameters showed improvement as a result of the treatment. Even though bestatin was ingested for long periods of time by these patients, there was almost no development of adverse reactions to the treatment.
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PMID:[Clinical studies of bestatin on genitourinary cancer]. 398 76

We have studied the role of natural killer activity during the growth and dissemination of a transplantable renal adenocarcinoma (Renca) of spontaneous origin in BALB/c mice. The pattern of growth of this tumor accurately mimics that of adult human renal cell carcinoma in terms of clinical stages I-IV, particularly with regard to spontaneous metastasis to lung and liver. Renca is moderately sensitive to lysis by natural killer cells from normal mice and is more efficiently lysed by natural killer cells from mice treated with the biological response modifier maleic anhydride divinyl ether, a pyran copolymer. Our studies demonstrate that selective depression of natural killer activity by administration of antiserum specific for the neutral glycosphingolipid asialo GM1 correlated with increased formation of spontaneous metastases in the lungs, liver, and lymph nodes. Conversely, augmentation of natural killer activity by the biological response modifier decreased the formation of spontaneous metastases in lungs, liver and lymph nodes. Further, the suppression of natural killer activity and subsequent increased formation of metastases were accompanied by a significantly reduced survival time, whereas the augmented natural killer activity and decreased incidence of metastases in biological response modifier-treated mice were accompanied by an increase in time of survival. These results demonstrate a significant role for natural killer cells in the control of spontaneous metastasis during growth of this murine renal cancer.
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PMID:Role of natural killer activity in development of spontaneous metastases in murine renal cancer. 405 25

Thirty-three patients operated on for pulmonary metastases from renal cancer were followed up for a minimum of 5 years or to death. The 5-year survival was 21%. There was a tendency to better survival in patients operated by lobectomy rather than limited resection. Extended operations carried a grave prognosis. Manifest metastatic disease within one year after the primary operation showed shortened survival. Repeated operations were possible, with good results. It is concluded that operations for pulmonary metastases can be performed with good results. However, the effect is a palliative one as the ultimate cause of death in all instances was the spread of the cancer disease.
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PMID:Surgical removal of pulmonary metastases from renal cell carcinoma. 405 76


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