Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Breast carcinoma has a metastatic potential to any organ system. However, breast carcinoma metastases to the urinary tract have very rarely been described. The authors present the case of a patient with a synchronous right ureteral and vesical metastasis of a breast cancer. This is the unique case reported in Literature of synchronous urinary metastatic localization from breast invasive lobular carcinoma.
 ...
PMID:Synchronous urinary tract metastases from breast cancer. 2108 98

Breast carcinoma (BC) is one of the most common osteotropic tumors. The subset of BC patients with isolated bone metastasis (IBM) forms a clinically distinct group and often has a favorable clinical outcome as compared to others with metastatic BC. We analyzed all BC patients with distal organ metastasis in our institution between 1997 and 2003 (N = 198) to identify the clinicopathologic features of BC with IBM and compare them to those with metastasis to other sites. We found that 63% of BC patients with advanced disease had bone metastases, and 44% of those were IBM. The proportion of cases with IBM that expressed estrogen receptor and/or progesterone receptor (47/52; 90%) was significantly higher than those with non-bone metastases (P < .0001) and than those with multiple metastases involving bone (P < .0001). The distribution of BC molecular subtypes in cases of IBM was again significantly different from that of the remainder. By univariate and multivariate analysis of the clinicopathologic factors examined, only estrogen receptor and progesterone receptor status of the primary tumor was predictive for IBM. The median survival after diagnosis of metastatic disease was significantly longer in cases with IBM than that of any other group. Our results indicate that the diversity in receptor expression patterns not only reflects the biological diversity of mammary tumors but may also predict their metastatic potential and thus could potentially be used in surveying women patients with nonmetastatic disease.
 ...
PMID:Breast carcinomas with isolated bone metastases have different hormone receptor expression profiles than those with metastases to other sites or multiple organs. 2116 79

Breast carcinoma is the most common cancer of women. Bones are often involved with breast carcinoma metastases with the resulting morbidity and reduced quality of life. Breast cancer cells arriving at bone tissues mount supportive microenvironment by recruiting and modulating the activity of several host tissue cell types including the specialized bone cells osteoblasts and osteoclasts. Pathologically activated osteoclasts produce osteolytic lesions associated with bone pain, pathological fractures, cord compression and other complications of metastatic breast carcinoma at bone. Over the last decade there has been enormous growth of knowledge in the field of osteoclasts biology both in the physiological state and in the tumor microenvironment. This knowledge allowed the development and implementation of several targeted therapeutics that expanded the armamentarium of the oncologists dealing with the metastases-associated osteolytic disease. While the interactions of cancer cells with resident bone cells at the established metastatic gross lesions are well-studied, the preclinical events that underlie the progression of disseminated tumor cells into micrometastases and then into clinically-overt macrometastases are just starting to be uncovered. In this review, we discuss the established information and the most recent discoveries in the pathogenesis of osteolytic metastases of breast cancer, as well as the corresponding investigational drugs that have been introduced into clinical development.
 ...
PMID:Breast cancer at bone metastatic sites: recent discoveries and treatment targets. 2148 91

Intraocular choroidal metastasis is a very rare cause of blindness. Choroidal hemangioma and melanoma are other causes that may mimic the condition. Carcinoma of breast is the most common primary malignancy that accounts for choroidal metastasis in females and carcinoma of lung is the most common cause in males. Other primary neoplasms which can uncommonly metastasize to the choroid are testis, gastrointestinal tract, kidney, thyroid, pancreas, and prostate. Metastatic neoplasm to the eye outnumbers the primary tumors such as retinoblastomas and malignant melanoma. Sonography is usually the initial investigation after fundus examination to look for the architecture of the lesion. However, it lacks in specificity. We present a case of carcinoma of breast that had visual disturbances and wholebody F18-fluorodeoxyglucose, positron emission tomography-computerized tomography (FDG PET CT) revealed a choroidal lesion in addition to cerebral, pulmonary, and skeletal metastases. Choroidal metastasis from carcinoma of lung has been reported previously on FDG PET. To the best of our knowledge, this is the first case report of carcinoma of breast demonstrating choroid metastasis on F18-FDG PET CT scan.
 ...
PMID:Choroidal metastasis from carcinoma of breast detected on F18-FDG PET CT scan: A case report and review of literature. 2171 25

Breast carcinoma is the most common nondermatologic cancer diagnosis in women. Common metastatic sites include lymph nodes, lung, liver, and bone. Breast carcinoma metastatic to the bladder has been reported only sporadically. Most patients were symptomatic breast cancer with evidence of disseminated disease at the time of diagnosis. Metastasis usually occurred many years after diagnosis, and the prognosis was poor. We report a case of breast caricinoma metastasizing to the urinary bladder and retroperitoneum, which presented initially with acute renal failure. Patient was treated with bilateral per cuteneous nephrostomies and chemotherapy. Starting from this clinical case we review the available literature on this issue. Patients with breast cancer presenting with urinary symptoms should be examined for possible bladder metastasis.
 ...
PMID:Breast carcinoma metastasizing to the urinary bladder and retroperitoneum presenting as acute renal failure. 2171 77

Breast carcinoma-induced angiogenesis helps meet growing metabolic needs of tumors and progressively increases with malignant transformation of benign ducts to ductal carcinoma in situ (DCIS) and ductal carcinoma in situ to invasive carcinoma. There are conflicting data regarding the difference in angiogenesis in low-, intermediate-, and high-grade ductal carcinoma in situ. If angiogenesis is related to ductal carcinoma in situ progression, the types of ductal carcinoma in situ with more aggressive biologic potential would have different vascular patterns than the less aggressive ones. In this study, we classified 51 cases of ductal carcinoma in situ as low (10-20 years to progression to invasive carcinoma), moderate, or high aggressive (2-5 years to progression to invasive carcinoma), based on criteria outlined by Tsikitis and Chung (Am J Clin Oncol 2006; 29:305), which takes into account nuclear grade, mitotic rate, Ki-67, Her2Neu, P53, estrogen, and progesterone receptor expression. We correlated these 3 groups of ductal carcinoma in situ with the extent of periductal and stromal vascularity and the presence and type of vascular breaks. No association of aggressive biologic behavior of ductal carcinoma in situ with any vascular pattern was found. Moreover, no correlation was found between vascular patterns and classifiers of aggressiveness, microvascular density, or outcome (local recurrence, invasive carcinoma, or metastatic disease). To validate our cohort, we confirmed expected correlations of all measured parameters of aggressiveness by correlating them with each other. In summary, vascular patterns in ductal carcinoma in situ do not correlate with the predictors of aggressive behavior, suggesting that the biologic potential of ductal carcinoma in situ is independent of angiogenesis.
 ...
PMID:Predictors of disease progression in ductal carcinoma in situ of the breast and vascular patterns. 2192 5

Breast carcinoma continues to be the most common neoplasm in women, with a lifetime risk affecting approximately 1 in 8. Factors affecting prognosis include the size and grade of the primary lesion, regional axillary lymphadenopathy, the presence of hormonal receptors, and distant metastatic disease. Although metastatic breast disease usually affects the lungs, bones, and brain, abdominal association is not as common. Interestingly, lobular carcinoma, a subtype that only accounts for a minor portion of breast cancers, usually has luminal gastro-intestinal involvement. We describe a 57-year old Caucasian female with recurrent episodes of abdominal pain and concurrent intermittent obstructive symptomatology with overflow diarrhea over a one-year period. Conventional endoscopic and imaging workup was unrevealing. Capsule endoscopy was used, but this caused a complete bowel obstruction necessitating surgery, and subsequent resection of a strictured segment. Pathological examination yielded metastatic adenocarcinoma, consistent with origin in breast, lobular type. Immunohistochemistry confirmed the origin. Luminal gastro-intestinal involvement is a rare, yet recognized, site of breast adenocarcinoma metastasis; it is even more uncommon with an undiagnosed primary. It may mimic other gastro-intestinal disease, and as such, it would be prudent to maintain a modest index of suspicion given the high prevalence of breast neoplasia.
 ...
PMID:Small bowel obstruction as the primary presentation of undiagnosed metastatic lobular breast carcinoma. 2196 4

Breast carcinoma (BC) is a heterogeneous disease in terms of histology, therapeutic response, dissemination patterns to distant sites and patient outcomes. Triple-negative breast cancer (TNBC), defined by the lack of protein expression of estrogen and progesterone receptors and the absence of HER2 protein overexpression (ER-/PR-/HER2-) has significant clinical implications due to their poor prognosis and the lack of targeted agents. Skin involvement is one of the most distressing presentations of locally recurrent breast cancer and few studies have identified effective agents in this setting. In fact, the increasing use of anthracycline/taxane-based chemotherapy in the neoadjuvant and/or adjuvant settings has led to investigate new cytotoxic therapies such as the combination of pegylated liposomal doxorubicin (PLD) with gemcitabine. Here, we report two cases of disseminated TNBC with extensive cutaneous metastases and a remarkable response to PLD in combination with gemcitabine. Further investigations are needed to confirm the efficacy of this regimen in skin involvement and TNBC.
 ...
PMID:Activity of pegylated liposomal doxorubicin in combination with gemcitabine in triple negative breast cancer with skin involvement: two case reports. 2252 26

Breast carcinoma with visceral metastasis to the lungs, liver, and bone is common. However, isolated splenic metastases from breast carcinoma are rare. This has been rarely described in the medical literature. This case report presents a 48-year-old woman with newly diagnosed breast cancer and an isolated splenic metastasis diagnosed by ultrasound-guided fine-needle aspiration (FNA). Radiologic staging revealed no involvement of other organs, such as lungs, liver, or bone. The pathogenesis of rare single splenic metastasis and the diagnostic role of FNA on the spleen lesion are discussed. This case is being reported due to its rare metastatic initial presentation and the role of FNA in achieving the diagnosis.
 ...
PMID:Isolated splenic metastasis from carcinoma of the breast: a case report. 2264 93

Background. Breast carcinoma is the most common malignancy in women worldwide. It is most commonly associated with metastases to the liver, lung, bone, and the brain. Invasive lobular carcinoma is a less common pathology with slightly higher metastases to the upper gastrointestinal tract. Invasive lobular carcinoma metastasis to the gallbladder is extremely rare. Method. In this paper we are presenting a case of a 67-year-old female with metastases of invasive lobular breast cancer to the gallbladder six years after her therapy. Conclusion. This case clearly signifies the nature of the micrometastatic foci of the invasive lobular carcinoma even many years after a successful treatment.
 ...
PMID:Biliary dyskinesia as a rare presentation of metastatic breast carcinoma of the gallbladder: a case report. 2293 93


<< Previous 1 2 3 4 5 6 7 8 Next >>