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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cerebral metastases from colorectal cancer occur in 8% of cases. Diagnosis is usually made when primary disease and widespread metastases are already known. However, the detection of brain metastases as the first sign of colorectal carcinoma without any liver and/or lung involvement is extremely rare. Central nervous system metastases are more commonly seen in rectal cancer and often occur concurrently with lung metastasis. We report a case of a patient with brain metastases as the first clinical manifestation of an adenocarcinoma of caecum without any other organ involvement.
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PMID:Brain metastases as the first sign of colon cancer. 1805 30

Cerebral metastases from gastrointestinal primaries constitute about 3-5% of surgically resected brain secondaries. There has been a paucity of regional and worldwide data concerning the survival and clinical course of patients undergoing neurosurgical treatment of cerebral metastases from colorectal origin. The clinical course and survival of 32 patients undergoing neurosurgical intervention for colorectal carcinoma metastases between 1999 and 2007 was examined. The 21 male and 11 female patients examined had a median age of 61.8 years at diagnosis of colorectal cancer; median interval between colorectal cancer diagnosis and cerebral metastatic disease was 27.6 months; and 88% of patients underwent microsurgical resection. Median survival from neurosurgical intervention was 7.5 months. Perioperative mortality was 3%. Age, gender and infratentorial location of lesions had no significant impact on survival. Patients undergoing whole brain radiotherapy (WBRT) had a significantly longer survival than those not undertaking this treatment (median survival 10.6 vs. 5.2 months, p = 0.018). A randomised, controlled trial of the utility of WBRT following surgical resection in this tumour subtype seems appropriate.
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PMID:Survival of patients following neurosurgical treatment of colorectal adenocarcinoma metastasis in the Northern Sydney-Central Coast area. 1861 11

Cerebral metastases from papillary thyroid carcinoma are rare. They are aggressive tumours associated with a poor prognosis. We report a patient presenting with multiple cerebral metastases as the primary presentation of her disseminated disease. These metastases were treated with surgical resection followed by external beam radiotherapy and radioactive iodine therapy. We suggest that early diagnosis and treatment of cerebral metastases of papillary thyroid carcinoma can result in good outcomes.
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PMID:Multiple cerebral metastases as a primary presentation in papillary thyroid carcinoma. 2007 55

Cerebral metastases are the most common brain tumors in adults and are characterized by poor prognosis. Despite application of modern methods of treatment (microsurgery, radiation therapy, chemotherapy) survival rates of these patients remain low. This fact triggers development of new therapeutic options which are able to increase recurrence-free period and consequently overall survival. The article contains review of literature dealing with photodynamic therapy which is a newly introduced technique for treatment of cerebral metastases.
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PMID:[The role of intraoperative photodynamic therapy in complex treatment of cerebral metastases]. 2125 77

Cerebral metastases from any malignancy, including prostate carcinoma, may present as a meningeal mass, and differentiating the lesion from a meningioma can be challenging. We report the clinical and neuroimaging features of two patients with dural metastases from prostate carcinoma and discuss differentiation of metastatic lesions from meningioma. In both patients, it appeared that the prostate carcinoma had been successfully treated, and neither patient was found to have any other metastases at the time of diagnosis of the dural lesions.
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PMID:Intracranial dural metastatic prostate cancer can mimic meningioma: a report of two cases. 2187 30

Distant metastases of differentiated thyroid carcinoma are observed in 5-10% of cases. Cerebral metastases are common for papillary carcinoma while cranial bones are usually affected by metastases of follicular cancer. Diagnostics of metastases of follicular carcinoma is complicated due to absence of pathognomonic signs and in 42% of cases they represent clinical onset of the disease. Neurosurgical treatment of metastases is associated with difficulties caused by abundant vasculature and intimate contact with critical structures of the skull base. Nevertheless metastases of follicular thyroid carcinoma have relatively favorable course: after surgical resection and hormonal replacement therapy and local iodine radiotherapy life expectancy is 4.5 years longer.
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PMID:[Metastasizing of follicular thyroid cancer to the skull base]. 2237 56

Cerebral metastases from melanoma are generally associated with a dismal prognosis with survival ranging from 3 to 6 months after treatment. Systemic chemotherapy for these patients has limited effect and evidence for an overall survival benefit from randomised controlled trials is lacking. We report on a 59-year-old patient with a history of malignant melanoma who presented with multiple cerebral metastases after previous surgery and combined whole brain and stereotactic radiotherapy. She has been in sustained remission and in excellent clinical condition after treatment with continued cycles of oral temozolomide for more than 6 years. To our knowledge, similar prolonged survival has been described only once in patients with multiple cerebral metastases from melanoma. This case demonstrates that temozolomide for metastatic central nervous system (CNS) disease in melanoma patients may be highly effective without CNS toxicity.
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PMID:Survival over 6 years in a patient with brain metastases from melanoma treated with temozolomide. 2300 80

Cerebral metastases are the most frequent cerebral tumours. Surgery of cerebral metastases plays an indispensible role in a multimodal therapy concept. Conventional white-light, microscopy assisted microsurgical and circumferential stripping of cerebral metastases is neurosurgical standard therapy, but is associated with an extraordinarily high recurrence rate of more than 50% without subsequent whole-brain radiotherapy. Therefore, neurosurgical standard therapy fails to achieve local tumour control in many patients. The present conceptual paper focuses on this issue and discusses the possible causes of the high recurrence rates such as intraoperative dissemination of tumour cells or the lack of sharp delimitation of metastases from the surrounding brain tissue resulting in incomplete resections. Adjuvant whole-brain radiotherapy reduces the risk of local and distant recurrences, but is associated with a well-documented impairment of neurocognitive function. New surgical strategies, such as supramarginal or fluorescence-guided resection, address the possibility of infiltrating tumour parts to achieve more complete resection of cerebral metastases. Supramarginal resection was shown to significantly reduce the risk of a local recurrence and prolongs two-year survival rates. Furthermore, radiosurgery in combination with surgery represents a promising approach.
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PMID:The tumour is not enough or is it? Problems and new concepts in the surgery of cerebral metastases. 2365 71

Cerebral metastases are the commonest central nervous system tumors. The MR assessment should include T1-weighted images with and without enhancement and T2/FLAIR images. They usually appear as multiple lesions with nodular or annular enhancement and are surrounded by edema. They are hypervascularized and have no restriction of their diffusion coefficient in their necrotic area and contain lipids on 1H spectroscopy. Metastases can be distinguished from primary tumors by the lack of malignant cell infiltration around the tumor. Stereotactic radiotherapy may temporarily increase tumor volume, although this is not of adverse oncological value. Less commonly, spinal disease may be asymptomatic and should be examined by MR.
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PMID:The different faces of central nervous system metastases. 2502 32

Cerebral metastasis secondary to prostatic adenocarcinoma is rare and it is usually a late complication in patients with widespread distant metastases. Here, we report two unusual cases of such a rare condition. Our first case presented with a large frontal contrast-enhancing lesion-associated calcification and a large tumor cyst as shown on computed tomography and magnetic resonance imaging. This is the fifth reported case of prostatic metastasis manifesting as a cystic intraparenchymal tumor in the literature. The second case presented with a large soft tissue mass in the scalp and this lesion appeared to invade through the skull and into the middle cranial fossa. He was not known to have prostate cancer before his initial presentation and it was only diagnosed following histology results of the scalp lesion.
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PMID:Metastatic Prostate Adenocarcinoma to the Brain: Case Reports and Literature Review. 2835 99


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