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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Guinea pigs were irradiated with 100, 200, or 300 rads of grenz rays four times weekly for two years (total doses were 32,600, 65,200, and 94,500 rads) and observed for an additional three years for development of cancer. Four animals of 11 developed squamous cell carcinomas. Three of the animals with squamous cell carcinoma of the skin had metastases in regional lymph nodes. The neoplastic cells showed the same degree of differentiation in the primary tumors as in lymph nodes.
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PMID:Metastatic cancer in guinea pigs irradiated with grenz rays. 57 Aug 23

In three new cases of sweat gland carcinoma that we observed within recent years, the sites were the axilla, back, and arm. Axillary lymph node dissections were performed in two of the patients and the nodes were normal. Preoperative diagnoses were hydroadenitis, squamous cell carcinoma of the skin, and pyogenic granuloma. In one patient who was followed up for four years, there has been no recurrence; the follow-up period for the other two has been short. Sweat gland carcinoma is an uncommon neoplasm that occurs mostly in the older age groups. It may be very slow growing and is extremely difficult to diagnose preoperatively. Lymph node metastases are frequent and overall survival is poor. Prognosis is related to histologic cell type and presence or absence of lymph node metastases. Treatment by wide local excision of the lesion and primary regional node dissection is recommended.
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PMID:Sweat gland carcinoma. Current concepts of surgical management. 94

Among 52 patients with squamous cell carcinoma of the skin of the pinna seen consecutively between 1952 and 1973, a single course of treatment failed to control the disease in 10 (19%). This failure rate is higher than that usually reported for squamous cell carcinomas of the skin in general (2 to 6%), and appears to be in conflict with the belief that squamous cell carcinomas of the skin of the pinna rarely metastasize. It appears that other factors than neglect are responsible for this discrepancy. In this series it was not possible to judge the relative efficacy of one mode of treatment over another.
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PMID:Squamous cell carcinomas of the skin of the pinna. 112 65

Persistent and/or late complications were analysed in 64 patients (183 fields) that were treated with combined hyperthermia and radiation therapy for advanced, recurrent or metastatic cancer. The incidence and type of complications were evaluated over a minimum follow-up period of 2 years from the onset of treatment (mean 38.7 months; range 24-82.5 months). The primary malignancies included: breast (39), melanomas (6), adenoid cystic carcinomas of salivary glands (4), prostate (4), soft tissue sarcomas (3), squamous cell carcinoma of head and neck (3), lymphomas (3), transitional cell carcinoma of bladder (1) and basal cell carcinoma of the skin (1). The persistent complications noted included induration and fibrosis (39 hyperthermia fields, 22 patients), ulceration at the site of prior tumour (three patients, three fields), and ulceration in normal tissue (one patient, one field). Brachial plexopathy developed in one patient treated for recurrent breast cancer, but she had active disease at that time. A squamous cell carcinoma of the skin developed within the treatment field in a breast cancer patient. Radionecrosis of the mandible was seen in one patient treated for a floor of the mouth cancer, and osteomyelitis with septic arthritis developed in one patient treated for a soft tissue sarcoma of the thigh. Univariate logistic regression analyses of pretreatment and radiation-hyperthermia treatment parameters revealed that maximal tumour temperature had a borderline significant correlation with the development of complications (p = 0.07). Multivariate analyses of the pretreatment and treatment parameters revealed the best-two-covariate model to predict complications included mean maximal tumour temperature and tumour type (macroscopic tumours had greater incidence of complications than for microscopic residual disease). The rate and type of persistent and/or late complications seen following combined radiation and hyperthermia did not appear to dramatically differ from those that would be anticipated from irradiation alone in this patient population, with the exception of an increased incidence of areas of induration and tumour necrosis.
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PMID:Persistent and/or late complications of combined radiation therapy and hyperthermia. 147 99

The incidence and outcome of metastatic squamous cell carcinoma of the skin is poorly documented. This study, undertaken in a population accessible to long-term follow-up, documents the metastatic aspects of squamous cell carcinoma of the skin of the trunk and limbs. In a review of 695 cases, metastases occurred in 34 cases, with a metastatic rate of 4.9%, an overall mortality of 3.4%, and a 70.6% mortality in the metastatic group. Forty-six per cent of overall mortality was associated with inoperable or recurrent regional disease without evidence of distant metastases. The risk factor associated with the development of metastatic disease were; delayed presentation; large neglected lesions; misdiagnosis; and multiple treatments to the primary lesions. In this series no correlation was found between the histological degree of differentiation of the primary tumour and the development of metastases. The mean latent period between treatment of the primary and the diagnosis of metastases was 11 months. Histopathological review of the regional lymph nodes in the operable group showed that adverse pathology such as multiple nodes, extracapsular spread, vascular and perineural invasion, were associated with regional recurrence and short survival. Twenty-one patients with operable metastases had a mean survival of 53.8 months. This was compared with 13 patients with inoperable disease, in whom the mean survival was 12.2 months (P less than 0.05).
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PMID:Squamous cell carcinoma of the skin of the trunk and limbs: the incidence of metastases and their outcome. 152 Jan 51

Metastasis of a cancer to another coexisting tumor is a very rare event. A case of primary squamous cell carcinoma of the skin metastatic to lymph nodes replaced by chronic lymphoid leukemia and diagnosed by fine needle aspiration is presented. To our knowledge, this peculiar case represents the first time that these two concurrent tumors were diagnosed by fine needle aspiration.
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PMID:Fine needle aspiration of squamous cell carcinoma of the skin metastatic to the site of leukemic lymphadenopathy. A case report. 158 Jan 26

Metastatic squamous cell carcinoma of the skin is associated with a poor prognosis even after surgical treatment or irradiation. Polychemotherapy can be used as an alternative regimen. We present a 65-year-old male patient with extensive metastatic squamous cell carcinoma of the skin after multiple surgical treatment and radiation. A combination of bleomycin, methotrexate and cisplatin, planned according to the anti-oncogram, resulted in rapid partial remission of the cutaneous metastases over several months.
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PMID:[Anti-oncogram-oriented polychemotherapy in metastasizing squamous cell carcinoma of the skin: impressive partial remission]. 170 64

The article analyses the specific features of lymphogenous metastasis of squamous cell carcinoma of the skin of the extremities and the surgical treatment of 189 patients. Lymphogenous metastases occur in each fourth patient with II-IV stage skin carcinoma. Carcinoma of the skin of the fingers and groin is distinguished by a marked tendency to lymphogenous metastasis. It is pointed out that the clinical diagnosis of carcinoma metastasis to a lymph node must be verified cytologically because enlargement of the node is often due to a reactive inflammatory hyperplasia of the lymphoid tissue. The specific features of surgical intervention in the zones of regional lymphogenous metastasis are noted. Metastasis of carcinoma into the inguinal lymph nodes must be managed by ilioinguinal lymphadenectomy.
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PMID:[Lymphogenous metastasis of squamous cell cancer of the skin of the limbs and their surgical treatment]. 206 43

The records linkage resources of the Rochester Epidemiology Program Project were used to identify 169 incident cases of invasive squamous cell carcinoma of the skin in the population of Rochester, Minn, between 1976 and 1984. The overall age-standardized incidence was 38.8/100,000 persons (63.1 in men; 22.5 in women). Metastasis occurred in 3.6%, and during an average of 3.8 years of follow-up, recurrence was seen in 3.6% while subsequent new lesions occurred in 12%. The demographics and course of patients with squamous cell carcinoma were different from either those of Bowen's disease or basal cell carcinoma in these population-based data.
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PMID:Squamous cell carcinoma. A population-based incidence study in Rochester, Minn. 230 56

A retrospective analysis of the data on 116 cases of squamous cell carcinoma of the skin of the body and extremities was undertaken. Eight parameters were found to influence metastasis formation and five-year survival: extent of involvement according to TNM classification, background conditions of tumor development, duration of disease, rate of tumor growth, gross appearance of tumor, site, contour and histologic pattern of malignancy. Recurrence development was influenced by nine parameters including those mentioned above plus extent of surgery. Tables for calculating likelihood of metastasis and recurrence development and five-year survival are provided. Credibility assured by these tables is as high as 75.0% in prognosing relapse, 96.4% in prognosing metastases and 93.6% in determining five-year survival.
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PMID:[Multifactorial analysis in the prognostication of the incidence of recurrences, metastases and survival of patients with squamous cell cancer of the skin]. 260 38


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