Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0027627 (
metastases
)
103,950
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Minimal deviation melanoma
is a recent concept of uncertain biologic significance. Minimally deviant melanocytes are not seen in
metastases
, suggesting they do not have the same biologic behavior as clearly malignant cells. Therefore, the Breslow and Clark prognostic criteria may not be applicable. Eight patients with MDM are presented. All were treated by scar re-excision and primary closure. Lesions ranged from 0.31 to 1.65 millimeters thick and four were Clark's level IV. Median follow-up study has been 19 months without evidence of local recurrence or distant metastasis. We concluded that MDM has a low likelihood for aggressive behavior in spite of tumor penetration which might suggest otherwise and that radical surgical therapy appears unnecessary.
...
PMID:Minimal deviation melanoma. 650 40
