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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Squamous cell carcinoma of the tongue has been found to have a greater frequency of cervical metastases on initial examination than lesions affecting other oral sites. This study analyzes a sample of 21 pathological specimens of oral carcinoma and block neck dissections relating the confirmed histological presence of cervical metastasis to the depth of invasion of the primary lesion. Tongue carcinomas were compared with lesions affecting other oral sites. An arbitrary anatomical levelling system was devised to assess the depth of invasion. Tongue carcinomas show a propensity to infiltrate more deeply than lesions affecting other oral sites. For the entire sample, carcinomas infiltrating the superficial lamina propria occurred much less frequently than lesions showing a deeper infiltration pattern. Overall, lesions infiltrating the deep lamina propria do not exhibit a reduced frequency of occurrence compared to lesions infiltrating the skeletal muscle; however, carcinomas affecting other oral sites showed a reduced frequency of deeply infiltrating lesions in comparison to more superficial lesions. Carcinomas confined to the superficial lamina propria seem to have a better prognosis in relation to developing cervical metastases, and this does not appear to be influenced by age, sex, site, size, or degree of differentiation.
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PMID:Cervical lymph node metastases of oral carcinoma related to the depth of invasion of the primary lesion. 371 87

Squamous cell carcinoma of the tongue tends to be an indolent disease. Tumors that present as small, localized lesions of the anterior tongue have a median five-year survival greater than 70 percent whether treated by irradiation or surgery. Distant metastases occur in only 7.5 percent. This report describes a well-differentiated T1N0M0 squamous cell carcinoma of the anterior tongue that progressed from diagnosis to death of the patient in less than nine months. At autopsy, the tumor had disseminated widely, including simultaneous metastases to all layers of the heart. It is concluded that factors other than morphology and anatomic extent at presentation may modify prognosis in squamous cell carcinoma of the tongue.
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PMID:Fulminant disseminated carcinomatosis arising from squamous cell carcinoma of the tongue. 396 78

Squamous cell carcinoma of the tongue and lower oral cavity is uncommon in patients under the age of 40 years. The site distribution and male to female ratio of patients differed markedly from those of the overall squamous cell carcinoma group. The tongue was by far the most common site, and the majority of patients were women. There were no apparent etiologic or biologic factors noted. Lymph node metastases occurred in 38 percent of our patients and were present in six of seven tumor-related deaths. Those patients who died usually had a poor response to initial treatment, and most were dead within less than 2 years after diagnosis. The overall cure rate in our study patients was much better than that for the overall group of patients, and this was especially so in patients with tongue cancer (80 percent absolute cure rate). Aggressive treatment and careful follow-up for recurrence or metastases are necessary.
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PMID:Squamous cell carcinoma of the tongue and lower oral cavity in patients under 40 years of age. 686 85

Squamous cell carcinoma of the tongue is one of the most common head and neck cancer. Treatment in the early stages is still controversial. This study aims to correlate the apoptosis rate of primary tongue cancer with cervical node metastasis, found in the histopathological studies of specimens obtained from neck dissections or during clinical follow-up. Twenty patients, 65% males, mean age 64.5 years, without clinical evidence of cervical metastasis was included. Eighty-five percent were smokers and 40% were alcohol abusers. Mann-Whitney test was used for statistical analysis (p<or=0.05). Five patients with clinically occult cervical metastases had metastasis in the histopathological specimens (25%) occult metastasis. The mean apoptosis rate in patients without cervical metastasis was 9.43%. Twenty-five percent of the patients had occult cervical metastasis. High apoptosis rate in tongue cancer, even in the absence of palpable neck nodes, correlates with the presence of occult metastasis.
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PMID:Apoptosis in tongue squamous cell carcinoma and its correlation with clinically occult cervical metastasis. 1817 47

We have investigated the clinical characteristics and prognostic factors of squamous cell carcinoma (SCC) of the tongue after definitive radiotherapy for nasopharyngeal carcinoma, and evaluated the effect of common therapeutic regimens for these patients. We retrospectively reviewed follow-up data for patients whose nasopharyngeal carcinoma had been treated by radiotherapy, and selected the 68 who had then developed SCC of the tongue, in the border of the tongue in half, and in the dorsum in 25 (37%). Eight of the 68 patients had clinical lymph node metastasis (12%), and 45 presented with stage I-II disease at the time of the diagnosis of the SCC (66%). Resection or radiotherapy alone was an effective treatment for patients with stage I-II SCC of the tongue, but patients with stage III-IV disease had a poor prognosis, despite being given multidisciplinary treatment. Multivariate analysis showed that the risk factors that independently influenced the survival of these patients were use of alcohol, recurrence of their nasopharyngeal carcinoma, the latency period, and the clinical TNM stage. Tongue SCC after radiotherapy was generally at an early stage and commonly occurred on the border or the dorsum of the tongue, with few lymph node metastases. Resection or radiotherapy is an effective treatment, and the risk factors that independently influenced the survival of patients indicate that improving the technique of radiotherapy and close follow-up after nasopharyngeal cancer are vitally important.
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PMID:Clinical and prognostic analysis of second primary squamous cell carcinoma of the tongue after radiotherapy for nasopharyngeal carcinoma. 2508 71