Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Carcinoma of Bartholin's gland is an extremely rare tumour representing approximately between 1% and 7% of the cases of cancer of the vulva. The aetiology of the tumour, which can be subdivided by means of light microscopy into squamous cell carcinoma, adenocarcinoma, adenoid cystic carcinoma and adenoacanthoma, remains unknown. Surgical and radiotherapeutic treatment is possible also in combination. If primary operative therapy is chosen, inguinal lymphadenectomy is required as usually suggested in all cases of cancer of the vulva; the metastatic involvement of the inguinal lymph nodes is regarded as the main prognostic determinant: if only one inguinal node has microscopic metastases, a five-year survival rate between 60% and 70% can be achieved in a selected operative group of patients. If more than four positive groin nodes are histologically diagnosed the survival rate - according to current results, not subdivided into different alternatives of therapy - is below 20%.
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PMID:[Primary cancer of Bartholin's gland]. 356 25

Bartholin's gland carcinoma is an uncommon disease representing 0.1% of all female genital malignant neoplasms. Five Bartholin's gland adenocarcinomas were selected by the criteria of Chamlian and Taylor. Three patients died from metastatic disease within four years; two are free of apparent disease 14 months and 13 years, respectively, after initial diagnosis. Poor prognosis was associated with large tumor size, poor histopathologic differentiation, and lymph node involvement. Transmission electron microscopy verified the glandular nature of the poorly differentiated lesions. All five tumors demonstrated junctional complexes, abundant rough endoplasmic reticulum, secretory vacuoles, and glandular formation. Low levels of estrogen receptor and moderate levels of progesterone receptor were present in the one case measured. Endogenous peroxidase, and inducible enzyme in estrogen-sensitive tissues, was observed in two of the five tumors.
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PMID:Adenocarcinoma of Bartholin's gland. 689 95