Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two monoclonal antibodies (mAb) to colorectal cancer were produced using a novel immunization technique. This involved immunizing mice with whole serum obtained from patients with cancer of the colon (three with metastatic disease) and resulted in antibodies which were reactive with colonic tumor tissue by immunoperoxidase testing. Two mAbs (O-1, I-1) were isolated which were non-reactive with normal tissue and with tissues obtained from subjects with benign disease but were reactive with 34/50 (formalin-fixed) colon carcinoma specimens. Further testing on cell lines and other malignant tumors suggested both mAbs detect carcinoembryonic antigen (CEA) as their reactivities were similar to a known anti-CEA antibody, and they reacted with CEA in a solid-phase radioimmunoassay. The two mAbs were found to react with the same or closely associated epitopes on CEA by competitive tests. As the anti-CEA antibodies were made to serum (rather than tissue) CEA, it was possible that unique, highly specific mAb has been produced, particularly as there was a selective reaction of the mAbs for malignant but not normal tissues. A serum test with mAb I-1 was developed which detected raised serum CEA levels in 3/24 patients with benign colonic lesions, 7/19 patients with pancreatic cancer, 5/25 patients with colonic cancer but not in 20 normal individuals. There was direct correlation between these results and a commercially available CEA test kit.
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PMID:Production of monoclonal antibodies to serum antigens in colorectal carcinoma. 328 75

In seven patients suffering from inoperable pancreatic cancer and in 14 patients with inoperable colonic cancer the half-life (T/2) of prostaglandin (PG)I2 in plasma in vitro has been determined before and at various intervals after irradiation. No significant difference of PGI2-T/2 could be observed either before irradiation, at the end of the irradiation period or 3 and 6 weeks after the last irradiation. Thus irradiation does not appear to interfere with the degradation of PGI2-T/2 in plasma. In patients with inoperable pancreatic and colonic cancer the PGI2-T/2 was not significantly different to that of the PGI2-T/2 of controls. Thus, a shortening of PGI2-T/2 is not a common feature in tumour patients. Hyperaggregation promoting seeding of metastases is not influenced by irradiation via the particular parameter of the PG-system.
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PMID:The influence of irradiation on the biological half-life of prostacyclin in plasma of patients with gastrointestinal cancer. 331 3

According to the TNM-System classification for the cancer of pancreas 331 subjects were collected. Some important factors were associated with the survival time of patients, i.g. the localization, the size and the histological type of tumors. It is well known that when distant metastases are found, only a palliative operation is possible while metastases in the regional lymph nodes are considered as a critical moment of the treatment of this disease. Teamwork is strongly recommended between the surgeon and pathologist to achieve better results as it is presented by classification. Following this fact it is possible to determine accurately the actual stage of any cancer of pancreas. As a result of the present findings it should be suggested to establish comparable and standardised programs for the treatment of pancreatic cancer.
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PMID:[The TNM classification of pancreas cancer]. 337 50

Radiation therapy has recently been used more frequently in the adjuvant treatment of gastrointestinal malignancies. A number of studies have shown a high local failure in patients with Stages B2 and C rectal carcinomas and in Stages B3, C2 and C3 colon carcinomas. In rectal cancer, both randomized and non-randomized studies have demonstrated improved local control and survival with the use of adjuvant radiation. Randomized studies have not been performed in colon cancer, but preliminary data from MGH indicate improved local control and survival in some patient subsets with the use of local irradiation after resection. Both gastric and pancreatic cancer have a greater propensity to distant metastases. A review of failure patterns after resection has, nonetheless, shown a high incidence of local recurrence and small prospective randomized studies have recently demonstrated a survival advantage with the use of adjuvant irradiation.
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PMID:Adjuvant irradiation of gastrointestinal malignancies: impact on local control and tumor cure. 351 55

The purpose of the present study was to clarify the anatomy of the lymphatic system of the para-aortic region with special reference to lymphatic pathways from the pancreas, and the incidence and extent of lymphatic metastases of pancreatic cancer to para-aortic lymph nodes. Lymph nodes were found mostly on the bilateral and anterior sides of the aorta, and rarely on its posterior side. Lymphatic vessels from the pancreas (peripancreatic nodes) were closely related to the para-aortic lymph nodes on the bilateral and anterior surfaces of the aorta ranging from the root of the celiac artery and that of the inferior mesenteric artery. Out of 10 autopsy cases of relatively small pancreatic cancer, 4 cases were found to have microscopic metastases in a few para-aortic lymph nodes. The localization of involved para-aortic nodes was compatible with that of anatomically related para-aortic lymph nodes. Lymph node dissection of the para-aortic region, if carried out in a patient with a possibility of radical resection of the primary pancreatic cancer, should be an en bloc resection of lymph nodes and surrounding soft tissues in the area ranging between the root of the celiac artery and that of the inferior mesenteric artery.
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PMID:[An anatomical and pathological study of autopsy material on the metastasis of pancreatic cancer to para-aortic lymph nodes]. 360 May 84

The transplantable mouse pancreas cancer cell line (MPC-83) has been established for two years, and transplanted serially into Kunming strain (KM) mice subcutaneously for 55 generations on Feb. 11, 1985. The transplantability rate in KM, BALB/C and Swiss mice was 100%. The tumor cells of some passages were stored in liquid nitrogen, and their revival was fine. It is the first transplantable pancreas cancer cell line ever established in China. The primary tumor was derived from a spontaneous pancreas cancer of a outbred male KM mouse. It was a poor-differentiated pancreatic acinar cell cancer. The transplanted tumors from all generations were similar to the primary one in both histology and histochemistry. The esterase staining was positive. By electron-microscopy, the zymogen granules were seen in the cytoplasm of its 1st, 25th and 33rd passages. The chromosome numbers in 28th, 32nd and 35th passages were hypertriploid with a modal number of 60 to 69, and some abnormal submetacentric chromosomes could be seen. The mean survival time of the tumor-bearing mice was 22 days. Metastases could be found in the lung (80%), sometimes in pancreas, omentum and other abdominal organs nearby with bloody cancerous ascites (10.5%). The fat necrosis might be noted around the tumor. These phenomena were similar to the clinical characteristics of human pancreas cancer. The preliminary therapeutic test shows that MPC-83 is sensitive to anticancer drugs such as 5-FU, Cyclophosphamide and cis-platin. This modal may be used for study of pancreas cancer, the mechanism of metastasis and antimetastatic agents of tumor, basic research and anticancer drugs.
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PMID:[Transplantable mouse pancreatic acinar cancer cell line (MPC-83) and its characteristics]. 373 17

Main primary sites of hepatic metastatic cancers were the stomach, colon, pancreas and esophagus. Those were found in 16.1% of 335 stomach cancer, 11.9% of 270 colon cancer, 27.1% of 70 pancreas cancer and 3.8% of 131 esophageal cancer at the time of operation. However, the metastatic lesions were resectable in 13%, 43%, 0% and 20%, respectively. Prognosis after hepatectomy was favorable only in colon cancer. 7 of 13 patients who underwent resection of the colon cancer and hepatic metastases are still surviving. The others all died. In inoperable cases, chemotherapy, especially intrahepatic arterial infusion, prolonged the survival time for months.
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PMID:[Surgical treatment of metastatic hepatic cancers]. 378 55

To examine the role of diabetes in pancreatic cancer, 4 groups of Chinese hamsters--2 from genetically diabetic and 2 from non-diabetic lines--were treated with N-nitrosobis(2-oxo-propyl)amine (BOP) at different dose levels and intervals. In one group (referred to as the VA group), BOP was given weekly at a 5 mg/kg body wt. level for 18 or 23 weeks, whereas the other group (the EP group) received a weekly dose of 2.5 mg/kg body wt. for life. Except for diet and experimental design, all other laboratory conditions were similar in the two institutions. No VA hamster developed tumors. Three of 22 non-diabetic EP hamsters (but none of the diabetic hamsters) developed pancreatic hyperplastic and neoplastic lesions, comprising ductular cell adenomas (3 hamsters), carcinoma in situ (1 hamster), a well-differentiated adenocarcinoma (1 hamster), and a poorly differentiated adenocarcinoma (1 hamster) with regional lymph node metastases. In addition, over 50% of the EP hamsters had neoplasms for which the incidences and morphology did not vary between diabetic and non-diabetic groups or between the sexes. These were primarily of the liver (cholangiomas), lungs (adenomas) and skin (trichoepitheliomas, squamous cell carcinomas). The differing carcinogenic response of the two hamster groups to BOP apparently is not related to the total BOP dose, but rather to other factors, including the length of observation time.
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PMID:Pancreatic carcinogenicity of N-nitrosobis(2-oxopropyl)-amine in diabetic and non-diabetic Chinese hamsters. 381 30

Out of 272 pancreatic cancer patients, 94 with hematogenous metastasis were clinicopathologically analyzed. The incidence of hematogenous metastases on laparotomy was 31.3 per cent in the liver, 1.8 per cent in the lung, 1.1 per cent in the adrenal gland and 0.4 per cent in the navel, respectively. The incidence of liver metastasis, in 22.9 per cent of the patients with carcinoma of the head of the pancreas and in 47.3 per cent of those of the body and tail of the pancreas, was higher than that of carcinomas of the other digestive organs. In autopsy findings, early metastases to the liver, lung, cerebellum and ovarium were evident. A higher rate of liver metastasis with lymph node involvement in the early stage of the disease was peculiar to cases of pancreatic cancer.
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PMID:Clinicopathological study on hematogenous metastasis of pancreatic cancer. 382 Aug 63

Encouraged by reports on immunoscintigraphy of colorectal carcinomas and by the results of our own immunohistochemical and immunoscintigraphic studies in nude mice with transplanted pancreatic carcinoma, we studied the diagnostic potential of immunoscintigraphy with a cocktail of 131I-labeled monoclonal antibodies against the tumor markers CA 19-9 and CEA in 21 patients with pancreatic cancer disease. The results were compared with those of 10 patients suffering from colorectal tumors, 2 cases with bile duct carcinoma and 1 with gastric cancer. Planar scintigraphy with 2-4 views was done repeatedly within 6 days after i.v infusion of 2 mCi of the antibody cocktail. SPECT was performed 3-4 days p.i., recently at 1 or 2 days, too. Primary tumors and metastases in the upper abdominal parts were more difficult to detect and to localise in comparison to colorectal cancer in the lower parts of the abdomen, because of relatively high tracer accumulation in kidneys, liver and spleen. Tumor enhancement in planar scintigrams was, in most cases, not recognized prior to 5 or 6 days p.i., but by SPECT 3 days p.i. or even earlier. Localisation and topographic determination were much easier and more frequent with SPECT, so that tumor detection became more reliable and sensitive. Large tumors could be detected in some cases without tumor marker concentrations in serum being elevated. Immunoscintigraphy of pancreatic carcinomas and of other cancer manifestations in the upper abdomen up to now seems to be of limited diagnostic value, the techniques involved need to be improved.
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PMID:[Immunoscintigraphy and SPECT in patients with pancreatic cancer]. 387 50


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