Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The case of a 63-year-old man with malignant mesothelioma of the tunica vaginalis testis confirmed by electron microscopy is presented. The tumor recurred in the scrotal skin and subsequently metastasized to the inguinal and retroperitoneal lymph nodes. Four and a half years after the original diagnosis, pulmonary metastases were discovered by cytologic examination of bronchial washings and confirmed by transbronchial lung biopsy. The cytologic features of the metastatic malignant mesothelial cells are described and compared to those of mesothelioma cells in body cavity fluids. The role of cytology in the early detection of such tumors is discussed.
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PMID:Cytology of mesothelioma of the tunica vaginalis metastatic to the lung. 385 91

Although malignant mesothelioma is known to spread hematogenously, brain metastases are rare. In the patient presented herein, multiple unilateral symptomatic central nervous system metastases developed that were diagnosed by computed tomography and documented at autopsy. Since malignant mesothelioma is occurring more frequently in the population at risk (asbestos workers), this complication may be observed more commonly in the future.
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PMID:Malignant mesothelioma with brain metastases. 394 56

Thirty men and 7 women with malignant mesothelioma seen at the Free University Hospital from 1st January 1960 until 1st July 1981 were reviewed. The histological, histochemical and morphometrical findings are reported. These findings are compared with 25 cases of pleural metastatic carcinoma and 25 cases of reactive pleural lesions. Fourty-nine percent of malignant mesotheliomas produced hyaluronic acid, however all cases of pleural metastatic carcinomas failed to produce this substance. All cases of malignant mesothelioma were D-PAS negative while 15 cases of pleural metastatic carcinoma showed reactivity to D-PAS. All cases of malignant mesothelioma and 9 cases of metastases were CEA negative. To distinguish malignant mesothelioma from metastases it is advisable to perform the D-PAS staining first. If it is negative mesothelioma can be confirmed by showing hyaluronic acid activity. A positive CEA staining rules out mesothelioma. In our study it was shown that with these methods 18 of 37 mesotheliomas could be identified with certainty, and 22 of the 25 carcinoma metastases. Morphometrically the malignant mesotheliomas could not be distinguished from the metastases, however the reactive pleural lesions had smaller nuclei than the malignant cells with mean values below 30 mu2. In the malignant cases these values had a range from 36 to 101 mu2. In distinguishing between reactive pleural lesions and malignant mesothelioma the production of hyaluronic acid points to the malignant character of the lesion. Thus histochemistry and immunostaining are important in the distinction of malignant mesothelioma from metastases, while the value of morphometry lies mainly in the seperation of reactive lesions from malignant mesothelioma.
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PMID:Histologic distinction between malignant mesothelioma, benign pleural lesion and carcinoma metastasis. Evaluation of the application of morphometry combined with histochemistry and immunostaining. 618 71

Adenocarcinoma of the rete testis is a rare tumor that tends to occur in men over the age of 60 and is usually associated with a poor prognosis. We report such a tumor occurring in a 63-year-old male 2 years after he underwent a scrotal exploration in the management of a hydrocele, varicocele, and inguinal hernia. The postorchidectomy course was characterized by slowly advancing, painful scrotal and perineal skin recurrences, lymph node metastases, and the absence of response to Adriamycin and electron-beam therapy. We are confident that the lesion is a carcinoma of the rete testis because: 1) the tumor is situated mainly in the testicular mediastinum, 2) primary germinal and nongerminal testicular tumors and spread from distant sources have been excluded, 3) a transition from normal rete testis to atypical and neoplastic rete epithelium is demonstrable, and 4) the transmission electron-microscopic findings support our conclusion. The distinction between carcinoma of the rete testis and malignant mesothelioma may be difficult and requires consideration of the gross, light-microscopic, and ultrastructural tumor characteristics in optimally fixed tissue.
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PMID:Adenocarcinoma of the rete testis. Case report, ultrastructural observations, and clinicopathologic correlates. 646 20

Metastases in multiple distant sites, including the skin, developed in a 54-year-old man with diffuse malignant abdominal mesothelioma. To our knowledge, this represents the first reported case of cutaneous metastasis arising from malignant mesothelioma. Recent advances in diagnostic techniques, such as electron microscopy, may be helpful in differentiating this condition from metastatic adenocarcinoma.
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PMID:Peritoneal malignant mesothelioma with multiple distant skin metastases. 661 51

Clinical and postmortem materials from six dogs with a diagnosis of malignant mesothelioma were studied retrospectively. The dogs were urban pets with clinical signs of malignant effusions. Two mesotheliomas were pleural, one pericardial, and one peritoneal. Both pleura and pericardium were involved in one dog, and the pleura and peritoneum in another. On gross examination at necropsy, diffuse granular or velvety plaques covering mesothelial surfaces were found in all dogs; firm discrete pleural nodules also were present in two dogs. Neither distant metastases nor areas of deep lung invasion were found. The tumors varied histologically, but the most common type was epithelial with a papillary pattern. Ultrastructurally, the neoplastic cells had prominent surface microvilli, numerous desmosomes, and tonofilaments. Lung tissue from these dogs and from control dogs was evaluated for the presence of ferruginous bodies. Asbestos bodies were found in three of five dogs with mesotheliomas but rarely were found in control dogs. As a group, the mesothelioma cases had significantly more asbestos bodies and total ferruginous bodies than controls. The clinical and morphologic appearance of canine mesothelioma is similar to human mesothelioma and also may be associated with exposure to airborne fibers.
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PMID:Malignant mesothelioma in urban dogs. 663 62

Formerly considered to be rare, primary malignant mesothelioma of the pleura has become a frequently diagnosed tumor during the last 30 years because of a more specific diagnostic criteria and because of its relationship with asbestos exposure. The radiologic findings associated with malignant mesothelioma of the pleura are not patho- neumonic but are characteristic and include a unilateral pleural effusion, unilateral pleural thickening, rib destruction and infra diaphragmatic spread, pulmonary nodules and masses and in distant metastases. These findings are in addition to the associated changes related to asbestos exposure. A review of the clinical records and radiographs of 26 patients with proven malignant mesothelioma studied at our institution serves as the basis for this review. The differential diagnosis radiologic findings and the relationship between these changes and the pathology clinical picture and the prognosis in this important disease entity is discussed.
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PMID:The radiology of thoracic malignant mesothelioma. 672 46

Seven children with malignant mesothelioma have been seen at Memorial Hospital since 1953. In six, the origin was at the pleura and in one at the peritoneum. None of the patients related a history of exposure to asbestos. Two patients lived more than five years. The other five patients died within two years of the diagnosis. Distant metastases were seen in four of the patients, including three who had metastases to brain. Surgery or radiotherapy were not effective in controlling the disease in most of the patients. One patient had a complete response to a combination of Adriamycin, cyclophosphamide, and vincristine and has remained free of disease for 5 1/2 years. The seven cases are reviewed, as are the other 42 cases of malignant mesothelioma in children reported in the literature.
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PMID:Malignant mesothelioma in children: report of seven cases and review of the literature. 679 Sep 17

Twenty-seven cases of desmoplastic diffuse malignant mesothelioma (26 pleural, one peritoneal) are described. In 19 cases the tumor cell type was sarcomatous and in six others it was biphasic (malignant elements of both epithelial and mesenchymal aspect). There were only two cases where the tumor cell type was purely epithelial. The clinical course was often rapid; the mean survival period in 11 cases of purely sarcomatous type was 6.18 months. Only one case of purely sarcomatous type lived for more than 1 year as opposed to four of eight cases with an epithelial component. Metastases occurred more frequently in desmoplastic (60.1%) than in nondesmoplastic diffuse mesothelioma (42.5%). The tumor cell type (epithelial, mesenchymal) accompanying desmoplastic mesotheliomas and not the extent of desmoplasia determines their behavior. Desmoplasia in diffuse mesotheliomas is often the result of tumor cells assuming the functional capacity of fibroblasts and has frequently been confused with reactive fibrosis. Cytologic abnormalities, tissue infiltration, and foci of necrosis indicate the neoplastic nature of the process in most instances.
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PMID:Desmoplastic diffuse mesothelioma. 710

An observation of malignant peritoneal mesothelioma in a man of 61 is presented. The clinical signs included fatigue, loss of weight, enlarged abdomen. The duration of the disease was 8 months. The autopsy revealed a whitish tumor of the peritoneum of cartilage density with numerous nodules 0.5-1.5 cm in diameter. The tumor overgrew the liver, spleen, pancreatic gland, stomach, and intestinal loops forming a single conglomerate. In the peritoneal cavity there were 4000 ml of transparent yellowish fluid. The visceral and parietal pleura on the left was thicker and covered with small whitish nodules. Histological examinations showed the peritoneum to be thickened, sclerosed and hyalinized. In the thickness of the fibrous stroma there were numerous slits lined with mesothelial cells. There were metastases in regional lymph nodes. The tumor had the structure of a malignant mesothelioma of the epithelial-like variant.
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PMID:[Malignant mesothelioma of the peritoneum]. 711 33


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