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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The computed tomography findings of three cases of adenocarcinoma of the colon metastatic to skeletal muscle are presented. The metastases ranged in size from 8 cm to 12 cm. Two of the cases demonstrated decreased attenuation and all cases demonstrated calcifications.
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PMID:Computed tomography of calcified metastases to skeletal muscle from adenocarcinoma of the colon. 316 40

Two cases of metastatic tumors involving the testis are reported: one from an adenocarcinoma of the prostate and the other from an adenocarcinoma of the colon. The first was found incidentally in the orchiectomy specimen done for prostatic cancer while the other was noted clinically as a part of a widely disseminated disease. Although there are numerous pathways through which tumors may metastasize to the testis, the occurrence of testicular metastasis is extremely rare. The reason for this rarity remains unknown.
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PMID:Metastatic tumors involving testis. 317 28

In 14 patients with adenocarcinoma of the colon or rectum (Duke stages A to D), positive results for neuraminidase were obtained with the isolated leukocytes at pH 6. These were tested by a cytochemical method using a chromogenic substrate for neuraminidase. Under the same conditions, normal leukocyte neuraminidase has a pH optimum of 4. The percentage of leukocytes showing neuraminidase activity increased with the progression of Duke stage and presence of liver or peritoneal metastases. Neuraminidase activity was also found in tumor and metastases specimens of these patients as well as in a human cell line derived from colonic adenocarcinoma (HT-29). Neuraminidase antibodies were found in blood and certain tumor materials. Neuraminidase inhibition tests were positive with neuraminidase inhibitors, patients' sera, N2 neuraminidase antibodies, and antisera against some type C retroviruses (GaLV and MLV), which were used because highly purified MLV preparations proved to contain biologically active neuraminidase (N2).
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PMID:Variation of leukocyte neuraminidase with Duke stage in patients with adenocarcinoma of the colon and rectum. 324 27

From May 1984 through December 1986, 141 patients with metastatic adenocarcinoma of the colon or rectum were entered on this Hoosier Oncology Group (HOG) trial evaluating the role of cisplatin in systemic therapy. Patients were stratified by the presence or absence of hepatic metastases and by performance status, and were subsequently randomized to receive fluorouracil (5-FU) (15 mg/kg/wk) alone or the same dose of 5-FU plus cisplatin (60 mg/m2 every 3 weeks). The total duration of treatment was six cycles (18 weeks). In 132 fully evaluable patients the objective response rates were 19% for 5-FU and 22% for 5-FU plus cisplatin. Statistically, the median survival times of 40 and 39 weeks were not significantly different (P = .62). However, the median duration of remission (MDR) was superior (P = .05) for 5-FU alone. This study fails to confirm clinically significant synergy of 5-FU plus cisplatin in the treatment of metastatic colorectal cancer.
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PMID:A prospective randomized trial of fluorouracil versus fluorouracil plus cisplatin in the treatment of metastatic colorectal cancer: a Hoosier Oncology Group trial. 328 33

Malignancies of the appendix are extremely rare. Of the reported cases, carcinoid tumors are most common, with mucinous cystadenocarcinomas and adenocarcinomas next in frequency. Adenocarcinoids, which share morphologic and clinical features that are a composite of adenocarcinomas and carcinoids, have been described. Concomitant second malignancies, most often in the GI tract, occur with greater than expected frequency in patients with appendiceal tumors. Treatment and prognosis are markedly different for each of the histologic variants of appendiceal malignancy. In general, carcinoid tumors (smaller than 2 cm in diameter) may be treated by appendectomy alone and are associated with long term survival. Adenocarcinomas, unless well differentiated and extremely superficial and localized, required hemicolectomy and confer a prognosis that is, stage for stage, similar to that of adenocarcinoma of the colon. Mucinous cystadenocarcinomas may spread widely through the abdomen, resulting in P peritonei, but can be associated with long survival duration if surgical treatment is aggressive. There is evidence that adenocarcinoids develop from simultaneous neoplastic change in two stem cell populations. Metastases may show histologic features of adenocarcinomas alone, of carcinoid tumors alone, or may resemble a composite neoplasm. The prognosis is variable and treatment recommendations are not well defined.
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PMID:Appendiceal malignancies. 328 76

Twenty-two patients with pulmonary metastases from adenocarcinoma of the colon and rectum had sputum samples examined for cytology. All patients had lesions demonstrated on chest roentgenography and eight patients also underwent bronchoscopy. Three or more sputum samples were examined for eight patients, two samples for seven patients, and seven patients had one sample only examined. In five of 22 patients, the sputum samples were reported to be unsatisfactory for cytodiagnosis. Of the remaining 17, nine patients had at least one positive result for metastatic adenocarcinoma and in two additional cases the sample showed atypical cells. The result was therefore positive or atypical in 11 of 17 patients (65 percent). The positive cytology rate reported (79 percent for multiple pulmonary metastases) represents an improvement compared with previously published work. In this study 14 patients had either one or two samples collected for cytology and it is likely that the positivity rate would have been higher if three samples had been collected.
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PMID:Sputum cytology for the detection of pulmonary metastases from colorectal carcinoma. 362 75

A retrospective review of 176 patients with adenocarcinoma of the colon who underwent total colonoscopy preoperatively demonstrated synchronous carcinomas in 3.4 percent and synchronous polyps in 55.1 percent. Full-column barium enemas (68 patients) failed to identify cancer in 22 percent of patients and synchronous polyps in 58 percent of patients, a statistically significant (P less than 0.001) number of false-negative examinations. Double-contrast barium enemas (30 patients) failed to identify cancer in 27 percent of patients and synchronous polyps in 42 percent of patients, also a statistically significant (P less than 0.007) number of false-negative examinations. Full column and air contrast barium enemas identified all index cancers with distant metastases. Air-contrast barium enemas failed to identify 40 percent of "early" index cancers (confined to the bowel wall, negative nodes), and full-column barium enemas failed to identify 32 percent. The incidence of synchronous carcinoma and polyps underscores the need for total colon evaluation when a primary carcinoma is detected. Because of the poor accuracy of barium studies, total colonoscopy is the method of choice for this evaluation.
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PMID:The role of colonoscopy in the assessment of patients with colorectal cancer. 369 53

Osseous metastases to the hand are rare. The primary site is usually in the lung, breast, or kidney. Two cases of metastatic tumor in the hand from adenocarcinoma of the colon are reported herein. These patients presented two and four years after initial resections of colonic carcinomas. General aspects of diagnosis, etiology, and management are discussed.
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PMID:Metastatic tumors in the hand from adenocarcinoma of the colon. 380 22

A 59-year-old woman who presented with bowel obstruction, a large pelvic mass, and marked breast tenderness was found to have strikingly elevated preoperative serum concentrations of estrogen and progesterone. After resection of a primary adenocarcinoma of the colon and bilateral ovarian metastases, her serum progesterone and estradiol concentrations gradually declined. The unusual hormone production in the patient was confirmed by regression of clinical symptoms and by in vitro endocrine assays performed on cells from ovarian tumor grown in tissue culture. The tumor consumed pregnenolone and produced progesterone and estradiol in large quantity.
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PMID:Progesterone production in adenocarcinoma of the colon metastatic to the ovaries. 400 May 74

A case of adenocarcinoma of the colon is reported, whose metastases exhibited a syncytiotrophoblastic differentiation that gradually increased with advancing distance from the primary. Immunohistochemically, syncytiotrophoblastic giant cells with strong positivity for beta-HCG could be demonstrated within the metastatic tissue. Also, there was beta-HCG positivity in a fraction of the atypical epithelial elements of the primary. The case is discussed with respect to the differential diagnosis, and the cause of the syncytiotrophoblastic differentiation is attributed to the phenomenon of genetic instability. The case shows that by virtue of genetic instability totally new differentiations may be elaborated, so that the phenotypical appearance of a given tumor does not necessarily allow conclusions as to its tissue of origin. Thus, observations such as the one presented here clearly indicate that the histogenetic principle of tumor classifications by far does not apply to all cancers and that, therefore, its value and validity are considerably limited.
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PMID:Adenocarcinoma of the colon with syncytiotrophoblastic differentiation: differential diagnosis and implications. 403 56


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