Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0027627 (
metastases
)
103,950
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Paediatric high-grade gliomas, including glioblastoma and
anaplastic astrocytoma
, make up 8%-12% of paediatric central nervous system tumours
1
and have poor prognosis, with 2-year survival less than 30%
2
and overall survival less than 10%. The only known prognostic factors in this population include extent of resection and tumour histological grade. We present the case of a 9-year-old boy with disseminated
anaplastic astrocytoma
treated with subtotal resection, craniospinal radiation and temozolomide, with 8-year survival despite
metastatic disease
at presentation and subtotal resection. Next generation cancer gene panel sequencing revealed an usual pattern of 12 amplifications and four mutations not previously described.
...
PMID:Atypical anaplastic astrocytoma with unique molecular features and diffuse leptomeningeal spread in a child with long-term survival. 3076 49
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