Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Giant cell tumor of soft parts (GCTSP) is an extremely rare lesion with an unpredictable behavior. Some patients are cured with a simple surgical excision whereas others will develop metastatic disease within a relatively short interval. To date, there are no consistently reliable criteria, either clinical or histologic, to separate the benign from more aggressive lesions. We describe the clinical, histologic and radiologic features of a case with malignant behavior. The patient presented with a fungating skin and soft tissue mass and concurrent pulmonary nodules. The lesion recurred rapidly despite wide resection with negative surgical margins. Biopsy of the pulmonary lesions demonstrated metastatic disease.
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PMID:Malignant giant cell tumor of soft parts. 1499 49

Giant cell tumor of soft tissue is a rare neoplasm named for its resemblance to giant cell tumor of bone. According to World Health Organization classification of soft tissue tumors, it belongs to the category of the so-called fibrohistiocytic tumors of intermediate malignancy, characterized by frequent local recurrences unless widely excised, but only rarely metastases to lymph nodes and lungs. Cutaneous presentation is extremely rare. We described a case occurring in a 79-year-old woman who presented with a nodular, polypoid, ulcerated lesion on the paranasal region. The histomorphological features were consistent with the diagnosis of primary giant cell tumor of the skin. Clinical informations and immunohistochemistry are useful in distinguishing this neoplasm from other neoplastic and reactive lesions of the superficial soft tissues containing giant cells.
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PMID:Polypoid giant cell tumor of the skin. 1991 51