Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Periosteal chondrosarcoma occurs predominantly in the long tubular bones. The long-term survival rate is better and there are fewer local recurrences than with central chondrosarcoma. A case of periosteal chondrosarcoma is reported with a review of the literature. A 13-year-old girl presented with swelling of the distal right thigh of 3 weeks' duration. Radiographs and computed tomographic scan of the lesion showed a soft tissue mass, measuring 6 x 6 cm, with matrix calcification arising from the surface of the bone. An open biopsy followed by en bloc resection of the tumor was performed. The histologic features were those of a chondrosarcoma. An 8-year follow-up period has shown no local recurrence or distant metastases. The differential diagnosis of periosteal chondrosarcoma includes periosteal (chondroblastic) osteosarcoma and periosteal chondroma. Controversy exists as to whether periosteal chondrosarcoma is an entity distinct from periosteal osteosarcoma. The clinicopathologic features in this case and in the cases reported in the literature support the contention that periosteal chondrosarcoma is indeed distinct.
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PMID:Periosteal chondrosarcoma: a case report and review of the literature. 911 Oct 97

Periosteal chondrosarcoma (PC) is a rare low-grade malignant cartilaginous tumor originating on the bone surface. Wide surgical resection is the recommended treatment. Prognosis is usually good if surgery is adequate. Metastasis is late and very rare. We present the clinical, radiographic, and pathological features of a PC accompanied with fibular cortical invasion in a 30-year-old woman. Wide resection was performed at presentation, but a whole-body positron emission tomography/computed tomography (PET/CT) examination 10 months after operation showed multiple bone metastases (MBM) especially in the spine, pelvis, bilateral femurs, and humeri without local recurrence. To the best of our knowledge, the present report is the first concerning a PC with so extensive postoperative MBM but without local recurrence.
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PMID:Bony metastases following complete resection of periosteal chondrosarcoma. 2588 26