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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In this paper, a case of a 59-year-old female of primary malignant fibrous histiocytoma (MFH) of the lung is reported. The patient, who had dyspnea as a main complaint, presented with an abnormal shadow in the chest about 20 years ago, and rapid increase of the shadow has been recognized from one year ago. A pulmonary tumor of the left upper lobe was diagnosed by chest CT, bronchography, pulmonary arteriography. A left pneumonectomy was performed and metastases in lymph nodes and pleural dissemination were recognized. The tumor was 11 X 8 X 6 cm, white, multiple nodular, and solid with a clear border. Histologic examination showed the storiform pleomorphic type of MFH mixed with fibroblastoid cells and histiocytoid cells. Ga scintigram, bone scintigram, and CT conducted before and after the surgery did not show metastasis, but the patient died due to respiratory insufficiency caused by metastasis to the right pleura at 9 months after surgery.
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PMID:[A case report of primary malignant fibrous histiocytoma of the lung]. 164 6

An account is given in this paper of 6 women aged between 41 and 70 years in whom mesenchymal tumors developed after surgery and postoperative radiotherapy for mammary carcinoma. Malignant fibrous histiocytoma developed in 2 women, five and a half or ten and a half years after primary therapy. Angiosarcoma (Stewart-Treves syndrome) was recorded from another 2 women, three and a half or ten years after primary treatment. One women exhibited a chondrosarcoma, following an interval of six and a half years. Premalignant early phase of Stewart-Treves syndrome was diagnosed, after 8 years, in a woman who was 41 years of age. The criteria for assumption of post-radiogenic secondary tumor, as demanded by Cahan et al. (1948), are discussed in some detail. Its avoidance or early detection is considered to depend on individual, stage-related therapeutic planning and long-term follow-up of patients who had undergone surgery and postoperative radiotherapy for mammary carcinoma.
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PMID:[Mesenchymal tumors after surgery and radiation therapy of breast carcinoma]. 165 35

A rare case of larynx malignant fibrous histiocytoma is presented. Histologically and ultrastructurally, the tumour was similar to malignant fibrous histiocytoma of other organs. The patient was followed up for 2 years after surgical treatment and preoperative irradiation. No recurrence and metastases were observed.
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PMID:[Malignant fibrous histiocytoma of the larynx]. 165 53

Malignant fibrous histiocytoma (MFH) was found in the femur of a 28-year-old man who had suffered from chronic osteomyelitis. The patient had undergone surgery for a valgus knee deformity and the procedure was complicated by chronic osteomyelitis which lasted for 12 years. Four months after the onset of painful symptoms related to the occurrence of MFH, gross bone destruction with pathologic fracture and pulmonary metastases were present. The patient died 4 months later. Histopathological and immunohistochemical examinations indicated the diagnosis of MFH.
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PMID:Malignant fibrous histiocytoma in the course of chronic osteomyelitis. 166 83

Malignant fibrous histiocytoma (MFH) is the most common soft tissue sarcoma and is characterized by a variable morphology, which often creates difficulties in differential diagnosis. The clinical behavior and the pathologic features of 9 cases of MFH of the head and neck were studied. The cases presented demonstrate the poor prognosis of these lesions because of their strong tendency to recur locally and to form distant metastases, especially to the lungs.
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PMID:[Malignant fibrous histiocytoma of the maxillofacial region]. 166 58

The authors retrospectively reviewed data regarding 14 patients with sarcomatoid carcinomas of the lung seen and treated at M.D. Anderson Cancer Center from 1955 to 1986. The following were the histologic criteria for inclusion in the study: (1) the concurrent presence of malignant epithelial and sarcomatoid spindle cell components, and (2) positive immunoreactivity for antikeratin antibody or ultrastructural demonstration of epithelial differentiation in sarcomatoid tumors in which the epithelial component was inconspicuous. For the sarcomatoid components, the most frequent pattern was malignant fibrous histiocytoma, which was present in ten tumors. An unclassified sarcomatoid pattern was found in two cases and a fibrosarcomatous pattern in two remaining cases. Clinically, the median patient age was 59 years; 12 patients were male and 2 were female; 13 were smokers and 1 used snuff. Three patients had Stage I, ten had Stage III, and one had Stage IV disease. One patient with Stage I, seven with Stage III, and one with Stage IV disease died of their carcinomas 2 to 26 months after diagnosis (median survival time 12 months). All patients who had lymph node metastases at presentation died of disease. The authors concluded the following: (1) patients with sarcomatoid carcinoma of the lung usually presented at an advanced stage; (2) lymph node metastasis, as with a usual carcinoma of the lung, is an important prognostic factor; and (3) for all lung tumors with a sarcomatoid pattern, especially a malignant fibrous histiocytoma pattern, extensive samples should be obtained and immunoperoxidase or ultrastructural studies done to identify epithelial differentiation.
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PMID:Sarcomatoid carcinoma of the lung. Immunohistochemical and ultrastructural studies of 14 cases. 172 66

Determinants of 5-year survival were evaluated after complete resection of pulmonary metastases from adult soft-tissue sarcomas. Fifty-eight patients had complete resection (median survival 25 months, P = 0.0002), with a 25.8% absolute 5-year survival (15 of 58 patients); six patients had unresectable disease (median survival 6 months) and were excluded from additional analysis. Eleven patients remain disease free, with a median follow-up of 76 months. Significant independent prognostic indicators associated with improved survival (P less than 0.05) included metastasis doubling time of 40 days or greater (median survival 37 months versus 15 months if less than 40 days); unilateral disease on preoperative radiography (33 months versus 15 months if bilateral disease); three or fewer nodules on preoperative computed tomography (40 months versus 14 months if 4 or more nodules); two nodules or fewer resected (40 months versus 17 months if 3 or more nodules resected), and tumor histology (33 months for malignant fibrous histiocytoma versus 17 months for all others). Multivariate analysis identified the number of nodules detected by computed tomography preoperatively as having significant prognostic value.
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PMID:Five-year survival after pulmonary metastasectomy for adult soft tissue sarcoma. 173 Jan 17

Epidemiology and prognosis were analyzed in a consecutive, population-based series of 137 patients with malignant fibrous histiocytoma of soft tissue in the extremities and trunk wall, with a complete follow-up of minimum 3 years. All but one patient were treated by surgery in 28 cases combined with adjuvant radiotherapy or chemotherapy. The annual incidence was 0.42/10(5). The ratio men to women was 1.1. The median age was 64 years (range, 22 to 87 years). The thigh was the most common location. The median size was 6 cm. Superficial tumors constituted 43% and were smaller than deep-seated tumors. Eighty-three tumors were storiform-pleomorphic, 53 were myxoid, and one was of inflammatory type. The myxoid tumors were smaller and more often superficial. The cumulative 5-year survival rate for all patients was 0.7, but differed markedly between the histologic types; it was 1.0 in patients with myxoid tumors and 0.5 in patients with storiform-pleomorphic tumors. In the 77 patients with storiform-pleomorphic tumors without metastases at presentation, only tumor size larger than 10 cm and tumor necrosis independently impaired survival. The 23 patients who had none of these risk factors had a 5-year survival rate of 0.8.
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PMID:Malignant fibrous histiocytoma of soft tissue. A population-based epidemiologic and prognostic study of 137 patients. 184 50

A case is presented of a 55-year-old man with a MFH in a previous BI. The poor prognosis of such secondary MFH is related in part to the difficulty of its early diagnosis, its aggressive behavior, and its tendency to metastasize (mainly to bone sites and lungs). Nevertheless, although biopsy of asymptomatic bone marrow infarction is not indicated, MRI seems consistent in detecting sarcomatous transformation of symptomatic BIs and plays an important role in the patient's preoperative evaluation.
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PMID:Case report 656: Malignant fibrous histiocytoma in a previous bone infarct. 185 May 55

We analyze the clinical and histological features of 10 cases of malignant fibrous histiocytoma of soft tissue. Nine belonged to the pleomorphic-verticillate variety and one was myxoid. The initial clinical feature was a palpable mass in all cases except three with retroperitoneal localization, where constitutional symptoms predominated. After therapy (surgery in all, associated with radiotherapy in four), seven patients had local relapse and two had distant metastases. 50% died, with a mean survival of 13 months. We discuss the prognostic factors and the therapeutic approach, with emphasis on aggressive therapy and the need for radical surgery and postoperative adjuvant therapy.
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PMID:[Malignant fibrous histiocytoma of soft tissue: description of 10 cases]. 202 63


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