Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of cloacogenic carcinoma of the anus with pulmonary metastases successfully treated with adriamycin and subsequently with cis-dichlorodiammineplatinum(II) (CDP) is reviewed. Cloacogenic carcinoma of the anus is a very uncommon tumor, and this is the first report of a major response to chemotherapy alone. Adriamycin and/or CDP should be considered in the therapy of this tumor.
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PMID:Metastatic cloacogenic carcinoma of the anus: sequential responses to adriamycin and cis-dichlorodiammineplatinum(II). 62

Cloacogenic carcinoma is a rare tumor of the anorectal region originating from a persistant remnant of the cloacal membrane of the embryo. The tumor accounts for 2-3% of anorectal carcinomas and occurs more than twice as often in women. Most tumors present as fungating or ulcerating lesions, but the tumor may arise in anal ducts and present as a submucosal mass. Wide abdominoperineal resection is the treatment of choice with a five year survival of 50%. Metastases occurs to the inguinal lymph nodes in more than 50% of the patients at sometime during the course of the disease with distant metastases occuring most commonly to liver and lungs.
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PMID:Cloacogenic carcinoma. 66 78

Cloacogenic carcinoma, originating from the remnant of the cloaca, is a rare malignant tumor, comprising 2-3% of cancers of the anal canal. We reported here two cases of cloacogenic carcinoma whose pulmonary and hepatic metastases were successfully treated with CDDP administration, in spite of limited effect on primary lesions of the rectum. The promising usage of CDDP for cloacogenic carcinoma, especially for distant metastasis was discussed.
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PMID:[Two cases of cloacogenic carcinoma of the anal canal: chemotherapeutic effect of cis-dichlorodiammine-platinum]. 318 97

A case of cloacogenic carcinoma with cutaneous metastases in a 74 year old man is reported. The patient presented with a six months history of two polyps of the lowest portion of the anal canal. Physical examination of the inguino-scrotal area revealed a 5 X 7 cm. hard infiltrative plaque with three ulcero-vegetative scars. Histologic examination of both polyps revealed two of the four cytologic patterns described in this neoplasm. One polyp showed undifferentiated cells, type IV and second one, type II differentiated. The biopsy of the cutaneous metastases showed dermal infiltrative clusters of the cytologic type II differentiated epidermal cells. Treatment with radiotherapy and chemotherapy was ineffective. Cloacogenic carcinoma of the canal anal is a transitional cells neoplasm believed to arise from vestigial remnants of cloacal origin. Metastases occurred in 19% of cases but cutaneous colonization develops exceptionally.
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PMID:[Cutaneous metastasis of a cloacogenic tumor]. 332 Jun 23

A case of cloacogenic carcinoma of the anorectal junction with pulmonary metastases is presented. Treatment with Semustine (Methyl-CCNU) resulted in a partial response lasting 15 months. Cloacogenic carcinoma is an uncommon neoplasm against which only a few chemotherapeutic agents have been tried. Semustine should be considered in the treatment of metastatic cloacogenic carcinoma.
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PMID:Response of metastatic cloacogenic carcinoma to treatment with semustine. 730 17

From April 1958 through July 1976, 23 patients with transitional cloacogenic carcinoma of the anus were treated with curative intent by abdominoperineal resection alone (15 patients), combination abdomino-perineal resection and irradiation (6 patients), and irradiation alone (2 patients). None of these patients had been previously treated or had distant metastases at the time of presentation. Initial presentation survival, and complications of treatment are analyzed. Surgery alone failed to control local and pelvic disease in 1 of 6 patients with negative nodes (with a tumor greater than 2 cm in diameter) and in 6 of 9 patients with positive nodes. No local and pelvic failures occurred in patients treated with irradiation alone or preoperative or postoperative irradiation.
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PMID:Results of treatment in transitional cloacogenic carcinoma. 739 47