Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Six patients from one family and one solitary patient with juvenile polyposis coli are described. The histological changes in colonic polyps formed a spectrum from juvenile polyps, through focal to extensive adenomatous change, to adenocarcinomas. One patient aged 49 years had an adenocarcinoma of the colon and in another, aged 33, with rectal polyps and metastatic cancer this was suspected although the primary tumour was not located. Two additional patients, aged 19 and 41 years, had severe adenomatous dysplasia in a juvenile polyp. Four patients also had gastroduodenal polyps. The present findings clearly contradict the previous view that juvenile polyposis coli is not premalignant and only rarely needs surgical treatment. As other recent reports also describe frequent occurrence of neoplastic changes in juvenile polyps, colectomy, and ileorectostomy at the age of about 20 years is recommended as the treatment of choice for juvenile polyposis coli, as in patients with familial adenomatosis coli. Follow up should ideally include gastroduodenoscopy and inspection of the rectal remnant at regular intervals.
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PMID:Familial juvenile polyposis coli; increased risk of colorectal cancer. 673 58

Multifocal Merkel's cell tumors developed in a 24-year-old patient with an unusual cutaneous dysplasia syndrome. The neoplasms behaved in an aggressive fashion, with the development of multiple lymph node metastases. In this case, the dermatologic syndrome had features of both dyshidrotic ectodermal dysplasia and the basal cell nevus syndrome. In addition to Merkel's cell tumors, basal cell carcinomas and actinic elastosis were seen in sun-exposed skin sites. These findings, in conjunction with a known tendency for Merkel's cell tumors to arise in solar-damaged areas, suggest a pathogenetic relationship between these neoplasms and the underlying cutaneous syndrome in this patient.
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PMID:Multifocal Merkel's cell tumors associated with a cutaneous dysplasia syndrome. 684 21

The minimum requirements of the International Union against Cancer (UICC) to assess the TNM-classification of urothelial bladder cancer include since 1978 the clinical examination, urography, cystoscopy, bimanual palpation under anesthesia and biopsy or transurethral resection of the tumor. The single biopsy of the tumor should be supplemented by multiple biopsies of all bladder walls in combination with the resection of the tumor to diagnose multifocal tumor growth. The exfoliative urinary cytology should be included in the routine diagnostic regimen: cytology is helpful in detection of severe dysplasia and controls the histologically determined grade of the tumor. In selected cases computer tomography improves the accuracy of clinical evaluation of the depth of tumor infiltration. In our hands the lymphangiography can not assess the regional lymph node metastases: therefore, the staging operation is recommended before radical cystectomy is performed.
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PMID:[Clinical diagnosis of bladder cancer]. 700 82

Patients who have undergone implantation of ureters into the sigmoid colon (ureterosigmoidostomy) are known to be at high risk of developing cancer of the colon many years later. The operation is often performed in infancy for congenital abnormalities of the bladder, thus creating a long term surveillance problem. Six of 34 patients (17.6 per cent) who had undergone ureterosigmoidostomy were found at a screening fibresigmoidoscopy to have adenomas of the left colon or severe dysplasia of the stoma, a mean interval of 22 years after their urinary diversion. Four other patients had previously had a sigmoid adenoma or cancer; thus, 29 per cent overall had developed colonic neoplasms, almost all closely related to their stomas. Another patient who, by error, was excluded from the surveillance, died of metastatic cancer of the sigmoid colon within the study period. Regular surveillance by fibresigmoidoscopy of patients who have had urinary diversion affords the opportunity to detect and remove potentially malignant sigmoid lesions. In addition to its clinical importance, it allows a closer study of this unique model of colon carcinogenesis.
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PMID:Neoplasia and ureterosigmoidostomy: a colonoscopy survey. 710 16

The results of microscopic study of the material obtained from 71 cases of clinically-occult cancer of the breast are reported. Generally, metastases into axillary lymph nodes are primary clinical manifestations. A histological description of dysplasia and preinvasive cancer of the breast is presented. Metastatic spreading in regional lymph nodes unaccompanied by microscopically-detectable invasive tumor growth is discussed.
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PMID:[Early and "latent" breast cancer]. 730 56

Comprehensive immune function by integrated score was assessed in 158 operable, 55 inoperable, and 52 metastatic breast cancer patients relative to 107 healthy controls. The score was derived from in vivo response to PPD and DNCB and in vitro lymphocyte stimulation by PPD and PHA. Proportion of E-RFC was significantly lower in patients than in controls but was not found to correlate directly with the above functional criteria. Fifty-one percent of the patients with early, operable tumors were shown to be at least partially immunosuppressed by integrated score achievement vs. 11% of controls. This proportion rises to 68% of inoperable and 89% of metastatic patients. Quantitative analysis by graded response revealed an additional, significant degree of immune impairment in the respective patient groups by all testing parameters. Depression of immune function in operable patients was not related to age nor influenced by surgery. Immunocompetence of patients with mammary dysplasia did not differ from controls. Increasing size of primary tumor (T) was not found to be matched by progressive degree of immunosuppression, excepting that associated with large T4 tumors. Patients with lymph node involvement (N+) were not significantly immunologically inferior to those without (N0) where the larger operable T2-3) tumors are concerned. In the smallest, T1 tumors, nodal involvement (N+) is accompanied by remarkable immunosuppression relative to T1N0 cases. This finding suggests a pre-existing immune defect inherent in T1N+ patients. It supports the hypothesis that the immunosuppression associated with early breast cancer is primary, patient related. Secondary tumor-induced depression of immune response characterizes advanced and metastatic human breast cancer.
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PMID:Immunocompetence, immunosuppression, and human breast cancer. II. Further evidence of initial immune impairment by integrated assessment effect of nodal involvement (N) and of primary tumor size (T). 737 Sep 52

Between 1968 and 1976, 175 patients with severe dysplasia or carcinoma in situ were treated at the University of California, San Francisco. One hundred fourteen underwent therapeutic conization while 61 were treated definitely by hysterectomy. Bleeding was the main complication of cone biopsy. It occurred in 9.9% of all conizations, but only 2% of patients required transfusion. Although follow-up has been relatively short, two patients treated by therapeutic conization, who were lost to follow-up, subsequently developed recurrent invasive cancer and four have developed recurrent carcinoma in situ or severe dysplasia. One patient treated by hysterectomy has developed metastatic cancer and one has had a recurrence of severe dysplasia at the vaginal vault. There have been 32 pregnancies following cone biopsy with no increase in abortion or prematurity.
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PMID:The treatment of cervical intraepithelial neoplasia by cone biopsy. 740 84

Occasionally in cases of porcine intestinal adenomatosis (PIA) epithelial dysplasia is seen with infiltration of the epithelium into underlying tissues and spread, via the lymphatics, to drainage lymph nodes. The intracellular bacterium Campylobacter sputorum subspecies mucosalis, associated with PIA, can be demonstrated in the epithelial cells of the metastases. This dysplasia and infiltration appears to be related to surface damage and inflammation.
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PMID:Porcine intestinal adenomatosis: epithelial dysplasia and infiltration. 746 63

On an average 35%, of the carcinomas of the pharynx are localized in the hypopharynx. 44 carcinomas of the hypopharynx were analyzed which were observed 1970-1979 in the Institute of Pathology of the University of Hamburg. The age peak lays in the 7th decade of age. 84% of the patients were male. 68% of the cases were localized in the sinus piriformis, 21% in the posterior wall and 11% in the post-cricoid area. The stage T4 of the TNM classification existed in 87% of the cases, a formation of hematic pulmonary metastases in 40%. The highest frequency of metastases if found in the carcinomas of the sinus piriformis. According to the WHO classification 91% of the carcinomas were squamous cell carcinomas and 9% anaplastic carcinomas. 9% of the squamous cell carcinomas were high differentiated, 52% moderate and 30% poor differentiated. A very distinct stromal reaction was observed in the high differentiated carcinomas. The plasma cells showed a high content of IgA and IgG as revealed by the application of the indirect immunoperoxidase method. The content of Ig-containing plasma cells is distinctly reduced in poor differentiated carcinomas or after radiation therapy. A positive marking of carcinoembryonic antigen could be demonstrated in high and moderate differentiated carcinomas, especially in the keratinized areas. Prestages of the carcinomas are leukoplakias with dysplasia and papillomas, early stages the carcinoma in situ. Risk factors are tobacco abuse, alcoholism and the Plummer-Vinson's syndrome.
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PMID:[Morphological aspects of the carcinoma of the hypopharynx (author's transl)]. 746 54

Immunoscintigraphy with CYT-103, an 111indium-labelled immunoconjugate of B72.3, was evaluated in 10 patients before surgery for suspected or biopsy-proven primary colorectal cancer. The imaging results were compared with computed tomography (CT) findings at surgery, histopathology and immunohistochemistry. There were no adverse reactions following the administration of 1.0 mg 111In-CYT-103. Surgical and pathological findings identified 15 sites of disease (10 primary and five metastatic) and all but one lesion (severe dysplasia) were malignant. CT detected nine of 14 sites of malignancy compared to 12 as identified by immunoscintigraphy. It failed to detect two primary lesions and one case of peritoneal metastasis, all of which were imaged by CYT-103. Both imaging modalities failed to detect two of three cases with lymph node metastases and the dysplastic lesion (true negatives). The results indicate that 111In-CYT-103 imaging exhibits high sensitivity and specificity in the detection of primary and secondary lesions in patients with colorectal cancer.
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PMID:Immunoscintigraphy of primary colorectal cancers with indium-111 monoclonal antibody B72.3. 751 29


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