Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Sixty-one patients with invasive carcinoma of the cervix uteri underwent extraperitoneal pelvic and para-aortic lymph node sampling along with the exploratory laparotomy. Using the adverse surgical effects criteria modified from the G.O.G., the clinical course of this group of patients was analyzed, retrospectively. The demonstration of metastases had an adverse effect upon survival whether the metastatic disease occurred in the para-aortic or pelvic node regions. No substantial delay in the initiation of radiotherapy occurred regardless of the severity of toxicity.
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PMID:Pretreatment extraperitoneal surgical staging in primary carcinoma of the cervix uteri. 670 37

This is a retrospective analysis of 264 patients with Stage IB and IIA-B carcinoma of the cervix treated with curative intent at the University of Florida from October 1964 through April 1980. There is a minimum 2-year follow-up. Patients dead of distant metastases (13), dead from intercurrent disease (14), or lost to follow-up (1) less than 24 months from treatment with pelvic disease controlled were excluded from analysis of pelvic control. All patients were included in analysis of complications and survival. Tumor size and hematocrit were noted to be significant prognostic factors with regard to control of disease in the pelvis in Stage IB and IIA cancers. Tumor size and hematocrit also influenced pelvic control in Stage IIB, but to a lesser extent than in Stages IB and IIA. Patient age was a weak prognostic factor for control of disease in the pelvis for Stages IB, IIA, and IIB, but more strongly influenced pelvic control when considered in conjunction with tumor size and hematocrit. Overall treatment time influenced pelvic control in all cases when the size of the lesion was greater than or equal to 6 cm. In lesions greater than or equal to 6 cm in diameter, the amount of tumor regression noted at the time of the radium application after 3500 to 4000 rad external beam irradiation was a predictor of pelvic control. Data on treatment complications and survival are included, and future treatment strategies discussed.
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PMID:Prognostic and treatment factors affecting pelvic control of Stage IB and IIA-B carcinoma of the intact uterine cervix treated with radiation therapy alone. 672 23

During the years 1970-1978 one hundred nineteen patients with Stage IB and fifty-eight patients with Stage IIA carcinoma of the cervix were treated by combined preoperative radium and Wertheim hysterectomy with lymphadenectomy at the State University Hospital in Groningen. The overall 5-year survival was 87% for Stage IB and 70% for Stage IIA. The incidence of pelvic lymph node metastases was 14.8 and 35.4% in Stage IB and IIA, respectively. The presence of lymph node metastases was significantly related to the presence of residual tumour in the cervix after preoperative radium treatment (P less than 0.01) and was the most significant prognostic factor. The 5-year survival was 37% for those patients with node involvement as compared to 94% for those without lymphatic extension. Complications particularly concerned the urinary tract. The incidence of these complications was greatly reduced as experience grew.
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PMID:Radical surgery after preoperative intracavitary radiotherapy for Stage IB and IIA carcinoma of the uterine cervix. 673 63

All patients with carcinoma of the cervix, FIGO Stage IB, treated at the University of Minnesota Hospitals during a 10-year period were reviewed. Of the 220 patients 31 (14.0%) developed recurrent disease and did not survive. Thirteen patients had pelvic wall recurrences, with concurrent cervical involvement. No patient had a resectable pelvic recurrence. Hysterectomy was subsequently performed on 10 of the 172 patients who received radiation therapy. Carcinoma was not present in any of the operative specimens although two patients with adenocarcinoma later died of metastatic cancer. Median time of recurrence was 9 months, with median survival following recurrence of 6 months. Cervical cytology was not of value in the early diagnosis of recurrent disease. The 5-year adjusted actuarial survival rate for patients with adenosquamous carcinoma was significantly lower than that for patients with squamous cell carcinoma. The median age of patients not surviving with adenosquamous carcinoma was significantly lower than that for patients not surviving with squamous cell carcinoma. Patients with invasive carcinoma presumably confined to the cervix may have disseminated disease. It is essential such selected patients receive primary treatment that includes systemic therapy.
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PMID:Carcinoma of the cervix, FIGO Stage IB: treatment failures. 673 65

Twenty-two patients with biopsy-proved para-aortic lymph node metastases from carcinoma of the cervix (15 patients) or endometrium (7 patients) received a median dose of 5,000 rad/25 fractions. Para-aortic nodal metastases were controlled in 77% of cases. Control was significantly lower following radical retroperitoneal lymph node dissection than less extensive sampling procedures. Obstruction of the small bowel developed in 3 patients with tumor recurrence in the para-aortic region. Eight of the 10 patients who were disease-free at 2 years received greater than 5,000 rad. Three patients were still alive without disease at 129, 63, and 60 months, respectively. The 5-year disease-free survival rate was 40% for cervical cancer and 60% for endometrial cancer: in the former group, it was significantly different depending on whether the para-aortic nodes were irradiated (40%) or not (0%). The authors suggest that 5,000-5,500 rad in 5-5.5 weeks is well tolerated and can control aortic nodal metastases in cervical and possibly endometrial cancer.
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PMID:Irradiation of para-aortic lymph node metastases from carcinoma of the cervix or endometrium. Preliminary results. 682 38

Clinical records of 371 women with carcinoma of the cervix, Stage IB, treated in the decade 1969-1979 were reviewed. Cancer recurred in 67 women (18.1%). A group of 171 patients treated by radiation, including 25 who were surgically staged prior to treatment, was compared to 200 patients treated by radical abdominal hysterectomy and pelvic node dissection, including 35 who had postoperative whole pelvis radiation. A multifactorial analysis included time to recurrence, site of recurrence, treatment for recurrence, and survival after recurrence. Pathology review and clinicopathological correlation included tumor configuration, histologic type, size of tumor in greatest dimension, and rate of node metastases in patients undergoing either radical hysterectomy or surgical staging procedures. Lesion size was found to be the most accurate predictor of disease-free survival; this was true whether the patient was treated by surgery or radiation and was not significantly affected by the tumor histology. Nodal metastases were associated with increasing size of lesions and predicted high recurrence rates. Node metastasis rates were not affected by the histology of the tumor.
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PMID:Tumor recurrence and survival in stage IB cancer of the cervix. 684 44

These 2 case reports serve to emphasize two important points concerning carcinoma of the cervix: (i) blood-borne metastases are now frequently encountered in this disease; and (ii) in selected cases surgical excision of a secondary deposit in the lung is the treatment of choice and may even result in cure.
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PMID:Surgical excision of lung metastases from squamous carcinoma of the cervix. A report of 2 cases. 684 48

A survey of the lymphocyte status is reported for 25 patients given routine radiotherapy for carcinoma of the cervix or carcinoma of the breast and other tumours. After an initial lymphopenia there was a return to the initial value of the lymphocyte count by the end of a 12 month period of observation. The PHA index was also measured in these patients and this also showed a progressive rise during the 12 month period following a minimal change after radiotherapy. There was no significant difference between the lymphocyte status of patients given radiotherapy above or below the diaphragm nor between patients with or without knwon metastases at the end of the 12 month period. An additional sample of eight patients with carcinoma of the breast showed a rise in lymphocyte count after surgery before the usual fall after radiotherapy.
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PMID:Recovery of lymphocyte status after radiotherapy. 696 62

Percutaneous retroperitoneal lymph node biopsy was performed on 129 patients with carcinoma of the cervix, in whom a lymphangiographic study was reported as suspicious or positive for metastatic nodal disease. Of 159 total biopsies, 114 were performed on external iliac nodes and 45 on paraaortic nodes. An overall accuracy of 68% was obtained without significant complication. The sensitivity of the test was 58% and the specificity 100%. In patients with suspicious lymphangiograms for metastatic disease, percutaneous biopsy identified metastases in 32% of the cases. The predictive value of a negative test was only 42%, but the predictive value of a positive test 100%.
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PMID:Carcinoma of the cervix: percutaneous lymph node aspiration biopsy. 697 27

Two part collectives of patients with carcinomas of the uterus - one consisting of 525 conventionally irradiated patients, the other consisting of 577 patients irradiated with telecobalt - are compared with respect to their five-year survival recovery rate, the frequency of recurrences and metastases and the radiogenic complications. After having introduced the telecobalt therapy - intracavitary radium therapy remaining unchanged - the five-year survival recovery ameliorated by about 10% for carcinomas of the cervix as well as for carcinomas of the body of the uterus. The evaluation according to tumor stages showed that the telecobalt irradiation was particularly advantageous for operated and non-operated patients with a carcinoma of the cervix of stage II as well as for non-operated patients with a carcinoma of the body of the uterus. The authors discuss the possible reasons for the increase of recurrence rate and radiogenic complications observed in patients treated with telecobalt.
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PMID:[Five-year recovery of case of carcinomas of the uterus after conventional irradiation and after telecobalt therapy (author's transl)]. 705 42


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