Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Lymphography has been used to evaluate the pelvic and para-aortic nodes in 205 patients with carcinoma of the cervix treated between 1970 and 1979. The incidence of positive nodes was found to be 17% for Stage I, 24% for Stage II, 52% for Stage III and 100% for Stage IV. Of 73 patients who had lymphograms before Wertheim's hysterectomy, four out of 59 patients (7%) with negative lymphograms had histologically positive nodes; four out of 14 (28%) with positive lymphograms had negative nodes. Within each FIGO stage a positive lymphogram indicated a poor prognosis. The actuarial 5-year survival rates for patients with negative and positive lymphograms were 94% and 55% respectively for Stage I, 72% and 64% for Stage II, and 34% and 17% for Stage III. Of 39 patients with positive lymphograms who died of tumour, 31 out of 39 (80%) had distant metastases, compared with nine out of 29 patients (31%) with negative lymphograms. It is concluded that lymphography is a valuable method of evaluating lymph node status in carcinoma of the cervix.
 ...
PMID:The value of lymphography in the management of carcinoma of the cervix. 395 89

Stage IB or IIA carcinoma of the cervix in a nonselected series of 263 young (less than or equal to 40 years) women was managed with radiotherapy alone or in combination with radical surgery. When the tumor was detected in Stage IB, the 5-year survival rate was 81% in the radiotherapy group and 96% in the combined therapy group. The corresponding figures for Stage IIA were 74% and 66%, respectively. When lymph node metastases were present at operation, the 5-year survival rate was reduced. The reduction was relatively small in Stage IB, but was decreased from 83% to 27% in Stage IIA. The size of the tumor had prognostic impact on the survival rate. Residual tumor in the surgical specimens was likewise associated with poorer prognosis in Stage IIA. The prediagnostic duration of symptoms indicates that the longer the pretreatment time and higher the stage at diagnosis, the greater the likelihood of metastatic spread. Adenocarcinomas comprised 13% of the tumors in the series. Complications of treatment were few.
 ...
PMID:Outcome of different treatment modalities in cervix carcinoma Stage IB and IIA. Observations in a well-defined Swedish population. 396 2

In a series of 1347 patients with carcinoma of the cervix, 62 or 4.6% had metastatic spread to the bones. Bone metastasis correlated with more advanced disease, occurring in 39.1% of patients with Stage II disease. The role of isotope bone scanning and of the radiographic skeletal survey in the investigation of carcinoma of the cervix is considered. Eight patients having unusual radiographic appearances of skeletal metastases are discussed.
 ...
PMID:Unusual skeletal metastases in carcinoma of the cervix. 397 92

From 1 July 1974 to 31 December 1982, 127 patients with primary carcinoma of the cervix were assessed to determine the prognosis of patients with adenosquamous cell carcinoma. Of all patients, 34 are dead of disease for an overall corrected survival rate of 73.2%. The survival of 20 patients with adenosquamous cell carcinoma is 20%. Seventy-five percent of the adenosquamous cell patients had stage IB lesions. When patients with adenosquamous cell carcinoma were compared with patients with squamous cell carcinoma or adenocarcinoma, there was a statistically significant decrease in survival. Patients with adenosquamous cell carcinoma were relatively young with a mean age of 41.1 years. A normal appearing cervix was noted in 30% of all patients with adenosquamous cell carcinoma. The majority of adenosquamous cell patients (87.5%) dead from cancer had distant metastases. This report emphasizes that, independent of stage, adenosquamous cell cervical carcinoma is an extremely aggressive neoplasm and carries a poor prognosis.
 ...
PMID:Poor prognosis in patients with adenosquamous cell carcinoma of the cervix. 397 67

Two cases of occult invasive carcinoma of the cervix have been reported with emphasis on diagnostic failure and subsequent inappropriate treatments. A prompt replacement with malignant cells simulating dysplasia or carcinoma in situ was observed at the sites of cauterization preoperatively. However, histology of postoperative specimen showed apparent invasiveness in both cases and lymphatic metastases in one of them. These findings have led us to a concept that the present cases may represent a variety of occult carcinomas, which is in between the common and verrucous types of squamous cell carcinomas.
 ...
PMID:Undenuded invasive cervical carcinomas erroneously treated by cauterization. 402 95

Sixty of the first 100 patients with cervical carcinoma admitted for treatment in 1962-1966 were found prior to the institution of final therapy to have an invasive tumour. The diagnosis was not confirmed in five cases until semiserial sections had been made from conisation preparations or preparations from the amputated portio of the uterus. In the other cases it was confirmed by biopsy. Thirty patients belonged clinically to Stage I, 17 to Stage II, eight to Stage III and five to Stage IV. Forty six (= 75 per cent) of the patients had a radical operation; 28 of them were in Stage I, 16 in Stage II, one in Stage III and one in Stage IV. The other patients were given either radiological therapy or just palliative therapy. Pelvic lymphonodectomy was always performed in connection with abdominal operations (17 Wertheim operations modo Ball, 25 modo Meigs, one modo TeLinde and one exenteration). Two patients had a vaginal operation. Eleven patients had carcinomatous metastases in the lymph nodes of the pelvic wall. The operative mortality was nil. The severest complications were: one ureteral lesion which was sustained and repaired during the operation, one uretero-vesico-vaginal fistula which was repaired four months later and two cases of pulmonary emboli. The follow-up period is only from one month to four years six months. Three of the patients on whom a radical operation was performed have died during this period and six have had a recurrence. As has been emphasised in recent literature, the primary results show that some patients with carcinoma of the cervix can be treated operatively. Experience of radical operations is indispensable, for especially certain radioincurable and recurrent cases should be treated operatively if possible.
 ...
PMID:Primary results of the radical operations for invasive carcinoma of the uterine cervix. 529 16

Ionizing radiations have been shown to be carcinogenic to man as well as experimental animals. Malignancies following therapeutic radiation occur rarely. Over the past 10 years the authors recorded 10 cases of tumours in irradiated tissues. 3 occurred in patients irradiated for nasopharyngeal carcinoma, 3 were irradiated for tuberculosis adenitis, 2 for carcinoma of the cervix, 1 for carcinoma of the breast and 1 for basal cell carcinoma. The latent period for tumour induction following the irradiation varied from 5 years to 31 years. All these cases showed no evidence of recurrence or metastases of the original primary lesion; and the histology of the second primary differed from the first. Evidence of radiation damage was seen in all cases except for 2 patients who were treated for tuberculosis adenitis. The doses received varied from 900r to about, 9000r. Among the tumours produced, there were 3 cases of squamous cell carcinoma of the oral & postcricoid region, 2 cases of papillary carcinoma of the thyroid, 2 cases of adenocarcinoma of the rectum, 1 case of adenocarcinoma of the ethmoid, 1 case of osteosarcoma of the mandible and 1 case of extraskeletal osteosarcoma. The clinical features of these cases are discussed and other cases reported in the literature are reviewed.
 ...
PMID:Radiation induced cancer: a report of 10 cases. 627 26

Intracranial metastases in patients with carcinoma of the cervix are rarely reported. We present three such patients, two of whom had intraparenchymal metastases and a third with involvement of bone and dura.
 ...
PMID:Intracranial metastases from carcinoma of the cervix. 630 Oct 71

This paper describes a case of cancer of the uterine cervix (clinical stage IB) in which signs of brain metastases developed within 1 week of diagnosis. Common sites of distant metastases in patients with carcinoma of the cervix are the liver and lung parenchyma. However, these organs were free of disease and only the brain, an extremely rare site, was involved.
 ...
PMID:Brain metastases in early cancer of the uterine cervix. A case report. 662 33

The author studied clinicopathological parameters in patients with uterine cervical carcinoma in order to find the useful factors which would enable pretreatment estimation of the cancer spread. The following results were obtained. Histologically characteristic features of the primary lesions in the majority of the patients with Virchow's node metastases were lobular type according to the classification used in our department, L form in CPL classification, slight stromal reaction, large cancer nest, and loose connectivity between the cancer nest and stroma. In addition, they had a high incidence of clinical signs and data such as febrile condition, and increased ESR and CRP value. The percentage of comedo type gradually increased as the cancer spread (23.4%) in primary lesions, 40.5% in pelvic lymph nodes, 73.3% in Virchow's nodes). In the operated cases (stages Ib, IIa and IIb) with pelvic lymph node metastases, histological factors such as comedo type, L form, and loose connectivity, and at least one of the clinical characteristics were found more frequently than in cases without the metastases. In the irradiated cases (stages Ib, IIa and IIb) that died within 5 years, factors such as lobular type, loose connectivity and more than one clinical characteristics were seen more frequently than in cases that survived for more than 5 years. By giving appropriate points to items in the 3 most important histological factors (type, CPL classification and connectivity), grading of each group of cases was made; the high risk groups in both operated and irradiated cases scored significantly higher than the respective control groups. These suggests that some of the above parameters may be useful in evaluating the spread of carcinoma of the cervix.
 ...
PMID:[High risk factors in the spread of cervix carcinoma]. 666 46


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>