Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Eighteen patients with locoregional recurrence after primary surgery for carcinoma of the cervix and treated by radiotherapy were analyzed. An overall complete response of 88%, 16 of 18, was achieved. Five of sixteen patients (31%) developed a second locoregional recurrence. Response to radiotherapy seemed to correlate strongly with tumor volume. The overall 5-year survival for all 18 patients was 44%, and the disease-free survival, 39%. Only 22%, 4 of 18, had distant metastases in the subsequent course of the disease.
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PMID:Treatment of locoregional recurrence of carcinoma of the cervix by radiotherapy after primary surgery. 272 64

Malignant cells have the ability to invade and metastasize in great part because they secrete proteolytic enzymes. In order to investigate if the abnormal proteinase/antiproteinase balance of cancer bearing patients changes when the malignant tumor is destroyed, we studied 50 patients with invasive carcinoma of the cervix and 33 healthy women as a control group. Patients with cancer were treated with radiation according to the protocols of our hospital. The following serum determinations were performed: plasminogen activators (PA), cathepsin B (CB), antiproteinase alpha-1-antitrypsin (A1AT), trypsin inhibitory capacity (TIC) and antiproteolitic activity ratio (AAR), all of them before and after treatment. Serum proteolytic activity was elevated manyfold in all patients with invasive tumor as well A1AT. The antiproteolytic activity however, was significantly reduced to about 50% of its normal value in the same group of patients. In patients with good response to radiotherapy (tumor necrosis) a great reduction of proteinase activity as well as a recovery to normal of the AAR was observed. Contrary, in those with a poor response after radiation, proteolytic activity remained elevated and AAR diminished. It is concluded that serum PA, CB, A1AT and AAR values can be precise indicators of the presence of malignancy. These tests might be also of help for improving follow-up studies and for better prognostic estimates.
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PMID:[Protease-antiprotease balance in patients with invasive carcinoma of the cervix and uterus before and after radiotherapy]. 278 98

Adenoid cystic carcinoma of the cervix, traditionally associated with a poor prognosis, occurs in postmenopausal patients in the vast majority of cases reported. Only four cases have been reported in women less than age 40, and none in women less than age 30. Three new cases of adenoid cystic carcinoma of the cervix are reported in women aged 24, 27, and 38 years. All three patients were treated with radical pelvic surgery; lymph node metastases and vascular involvement were prominent. Adjuvant chemotherapy with cisplatin was used in two patients, one of whom has had long-term survival. A review of the literature is also presented.
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PMID:Adenoid cystic carcinoma of the cervix in women under age 40. 290 45

The following report describes the case history of a 40-year-old woman suffering from a squamous carcinoma of the cervix uteri stage IV with predominantly cutaneous metastases. After a combined treatment of local radiotherapy and polychemotherapy with cisplatinum, bleomycin and methotrexate, a complete remission of the disease has been achieved. Six months later, however, a local recurrence of the tumor in the cervix uteri was diagnosed. As the patient showed no evidence of metastases, a radical hysterectomy was then performed. While the chemotherapy was continued over longer time intervals, the patient lived for a further five months in good health and without any recurrence of the disease. More than one year after treatment was started, the patient died suddenly of uncontrollable cerebral metastases. Considering the unfavourable prognosis and the satisfactory quality of the patient's life after therapy, the course of treatment undertaken appears to have been justifiable.
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PMID:[Unusual course of metastatic cancer of the uterine cervix]. 291 9

Hilar and mediastinal lymphadenopathy are sometimes the only radiological manifestation of metastatic disease from extrathoracic neoplasms. This association has not been previously described with carcinoma of the cervix. We report two patients in whom hilar and mediastinal lymph node enlargement represented the first evidence of tumor recurrence.
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PMID:Mediastinal and hilar lymphadenopathy as the only manifestation of metastatic carcinoma of the cervix. 293 87

Following lymphography, a 41-year-old woman developed arthritis and papules of multicentric reticulohistiocytosis three years after the beginning of a carcinoma of the cervix, now inoperable and with vulvar metastases. Two further inevitable x-ray investigations with different contrast media led to exacerbation of the disease within 24 hours. 12 month after onset, all symptoms of multicentric reticulohistiocytosis receded spontaneously, and further investigations with contrast media were well tolerated. We assume that iodine compounds may be the cause--directly or indirectly--for provocation and enhancement of histiocytic proliferation.
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PMID:[Paraneoplastic multicentric reticulohistiocytosis: induced and inductable by iodine containing x-ray contrast media]. 299 Jan 17

Six patients with severe vaginal bleeding were treated with transcatheter embolization of selected pelvic vessels. Three patients had Stage III(b) carcinoma of the cervix, one with dysfunctional uterine bleeding and two patients had gestational trophoblastic disease (GTD) with bleeding from vaginal metastases. Bleeding stopped in four of the six cases. Reasons for failure in the other two cases are given. No other reports of bleeding from vaginal metastases in metastatic GTD treated in this way have been seen in the literature.
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PMID:Transcatheter embolization of pelvic vessels to stop intractable hemorrhage. 300 82

A retrospective analysis of 343 consecutive patients with histologically proven carcinoma of the cervix, treated at the Ottawa General Hospital, was undertaken to evaluate the prognostic significance of endometrial extension. All these patient had a D + C as part of their work-up. Sixty-seven patients had a (+) D + C: 34/150 (23%) in Stage IB, 21/106 (20%) in Stage II, and 12/87 (14%) in Stage III. Survival was closely related to the D + C findings in early stages. In Stage IB, the 5-year survival of D + C (-) patients was 90% vs 50% in D + C (+) patients (P less than 0.003) and in Stage II, the 5-year survival was 77% and 55%, respectively (P = 0.089). There was, however, no difference in survival in Stage III patients (35% vs 29%). Pelvic failures were similar in both groups, stage for stage, but those with a (+) D + C had a higher incidence of distant metastasis. In Stage IB, distant metastases were found in 8.5% (10/116) of D + C (-) patients compared to 38% (13/34) in D + C (+) patients (P less than 0.001) and in Stage II, in 18.5% (16/85 and 33% (7/21) of the patients (P = 0.126), respectively. There was no difference in Stage III patients (28% vs 25%). This study suggests that endometrial extension is a significant prognostic factor in early stages and is associated with a higher risk of distant metastases. Management of these high risk patients is discussed.
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PMID:Prognostic significance of endometrial extension in carcinoma of the cervix. 316 19

From January 1, 1946, through January 1, 1986, at the University of Michigan, 60 patients were treated with Stage IB (FIGO) carcinoma of the cervix with lymph node metastases. Clinical variables were examined with regard to long-term survival. Prognostically significant variables were (1) highest level of lymph node involvement and (2) tumor histology. Patients with common iliac or periaortic node involvement had an actuarial survival at 5 years of 14%; 5-year survival for patients with only pelvic node involvement (external iliac, hypogastric, or obturator) was 68%. Patients with adenocarcinoma or adenosquamous histology had an actuarial survival at 5 years of 16%; 5-year survival for patient with squamous cell carcinoma was 71%. Overall survival for all patients with lymph node involvement was 61%. For patients undergoing radical hysterectomy as primary treatment, postoperative adjuvant radiotherapy did not significantly improve survival.
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PMID:Stage IB carcinoma of the cervix with lymph node metastases. 318 10

Forty-five patients with carcinoma of the cervix stage Ib or IIa underwent primary radical surgery. The patho-histological examination of the surgical specimens showed, that pelvic lymph node metastases, tumour volume, depth of tumour invasion, lymphatic or vascular permeation and parametrial involvement were significant bad prognostic factors. The histological types of squamous cell carcinomas and local lymphoplasmocytic stromal reaction to the tumour had no statistical prognostic significance. A simple and objective method of assessing tumour volume is described. A 5-year actuarial survival rate for patients with metastatic pelvic lymph nodes (33% of the patients in this study) treated by surgery and additional postoperative external whole pelvis radiotherapy was 55%. This is significantly lower than the 86% 5-year actuarial survival rate of patients without pelvic lymph node metastases treated by surgery alone (P less than 0.05). The postoperative radiotherapy of carcinoma of the cervix with bad prognostic factors including pelvic lymph node metastases seems to improve local tumour control and perhaps survival in a subgroup of node negative tumours presenting other histopathological risk factors.
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PMID:Cancer of the cervix stage Ib and IIa: survival related to treatment and histopathological risk factors. 337 71


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