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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The value of lymphography in the diagnosis of lymph node metastases was investigated in 89 patients with stage Ib cervical carcinoma. All patients underwent radical hysterectomy. The lymphography (radiological diagnosis) was compared with the histopathological examination of the corresponding lymph nodes. The positive predictive value of the lymphography was 13% and that of the negative predictive value 98%. It is concluded that lymphography is not reliable for the diagnosis of lymph node metastases in cervical cancer stage Ib.
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PMID:Diagnostic value of lymphography in cervical cancer stage Ib. 262 70

Sixty-seven patients with cervical cancer stage IV were treated in 1967-72. Only 21 received a complete course of radiotherapy and none received surgery or chemotherapy. Two patients had mobile tumors with extension to the bladder. Both died from distant metastases without local recurrences. Two patients with metastases to the lymph nodes in the groin, died within 3 and 4 years, respectively. All the other patients with distant metastases survived less than 2 years.
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PMID:Carcinoma of the cervix stage IV treatment problems. 298 75

Intraoperative lymphscintigraphy during radical isotope surgery was performed in 242 patients suffering from cervical cancer and 170 patients with breast carcinoma. The results show a decreased rate of recurrence mortality in cervical cancer stage I and a decreased rate of recurrencies and metastases in breast carcinoma. In ovarian cancer patients radiommunoscintigraphy was introduced in the diagnostic procedure and is now performed intraoperatively. The results show a high positive prediction value of 93%. In 5 out of 28 patients radioimmunoscintigraphy identified tumor regrowth while all other methods failed.
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PMID:Radical isotope surgery: an enrichment for the surgical therapy of gynecological malignancies. 356 32

Twenty-four patients with cervical cancer stage Ib were examined by pelvic lymphoscintigraphy with 99mTc-colloid prior to operation. Four of the patients had histologically verified lymph node metastases. No difference in the lymphoscintigrams was found between the patients with pelvic metastases and those without. The removed involved lymph nodes did not contain less radioactive colloid than the histologically normal nodes. In two involved lymph nodes the uptake of radioactivity was far above any of the noninvolved nodes.
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PMID:Pelvic lymphoscintigraphy with 99mTc-colloid in lymph node metastases. 714 Jul 79

In a retrospective study the survival rates of 161 patients with stage Ib cervical cancer after radical operation (Latzko, Wertheim-Meigs) including complete or incomplete pelvine lymphadenectomy were compared. To increase radicality of lymphadenectomy, preoperative targeting of pelvic lymph nodes was done in all the patients using 99mTc-Sb2S3 radiocolloid. Intraoperatively, a gamma-camera being integral part of an operating table allowed delineation and scintigraphy-guided resection of pelvic lymph nodes. Dependent on the evidence of remaining pelvine foci of radioactivity at the end of the operation, lymphadenectomy was assessed as complete or incomplete. Mean observation time of completely lymphadenectomised patients (n = 117,72.67%) were 80 months (5-169 months) and 42 months (1-149 months) of the incompletely lymphadenectomised patients (n = 44,27.33%). In 28 (23.93%) completely lymphadenectomised patients against only 5 (11.36%) patients with incomplete lymphadenectomy, lymph node metastases were proved histologically. Five year-survival rate of completely lymphadenectomised patients was 85.47% and 88.64% of incompletely lymphadenectomised patients (not significant, Mantel-Test). Also, selective comparison of lymph node-positive patients did not suggest a divergent trend indicated by 13 (46.43%) deaths of completely and 3 (60.0%) deaths of the incompletely lymphadenectomised patients after an observation of five years. The technique of scintigraphy-guided pelvic lymphadenectomy using 99mTc-Sb2S3 radiocolloid cannot be expected to improve prognosis of patients with cervical cancer stage Ib.
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PMID:[The prognostic effect of scintigraphy-guided lymphadenectomy in therapy of stage Ib cervix carcinoma]. 755 19

Depth and extension of infiltration into uterine corpus with regard to 5 years survival in 33 patients in which Wertheim-Meigs surgery was done due to cervical cancer stage Ib is estimated in this paper. Endometrial stromal invasion or depth invasion less than 1/2 of myometrium at the site of internal ostium were of similar (91.7% > 5 years survival time) as an invasion confined solely to uterine cervix (86.9% > 5 years survival). Invasion of more than 1/2 of myometrium was associated with poor prognosis (46.7% 5-years survival). Bad prognosis (16.6% 5-year survival time) in patients with deep and extensive of uterine corpus and fundus should be tied to massive infiltration increased hematogenous and lymphatic dissemination. None of patients with deep and extensive invasion, lymph nodes metastases and uterine vasa embolies did survive 5 years period of time. These patients need individual postoperative adjuvant therapy.
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PMID:[The evaluation of endometrial invasion of cervical Ib grade carcinoma]. 977 Aug 49

In this research work we show our and foreign experience in preserving the ovarian function in young women and cervical cancer stage I B and II A. 6 cases are quoted for the period of time from 1987 till 2003 (4 patients with ovarian metastases from our experience and 2 patients with ovarian metastases found from the greek colleagues). Histologically 3 patients were with adenosquamous metastatic cervical cancers and 3 patients with squamous metastatic cervical cancers in the region of the transposed ovaries. The metastases occurred mostly 2 to 3 years after the radical hysterectomies a modo Wertheim-Meigs. Nevertheless our experience which is connected with radical hysterectomies a modeo W. Meigs including both ovaries, we have also experience in transposing ovaries /one or both of them/. In some of them we found metastases. In our research work we found 4 cases with metastases in transposed ovaries. In these cases a chemotherapy was applied: mitomicin C, etoposide, and cysplatinum. The greek colleagues also have applied such schemes of chemotherapy. 3 from the patients had a very good effect from the chemotherapy, in 2 the recurrences have appeared 2 years after the chemotherapy, and in one case there was a very big progression of the disease, nevertheless the chemotherapy. IT is very important for the oncogynaecologist to clear up if the transposition of the ovaries is safe and effective, especially in young patients with early cervical cancer receiving postoperative radiotherapy. That is why we did this research work in order to give more light on this problem.
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PMID:[Metastatic cancer in transposed ovaries after radical Wertheim-Meigs hysterectomy for a stage I B and II A cervical cancer]. 1468 9

We summarized the world experience as well as our experience in the surgical treatment of women with early cervical cancer stage IB with lymph node metastases, laterally extended parametrectomy was used. 62 women with IB stage cervical cancer who were with metastases of the pelvic lymph nodes were examined. The patients were followed for 20-120 months (median 56 months). 50 patients were alive and free from disease at the end of the researched period. We used the Kaplan-Meier 5 years cumulative proportion survival which was 82%. 8 complications were observed which necessitated a second operation. In 2 patients we had treatment-refractory incontinence. According to the foreign experience as well our experience the metastases in the pelvic lymph nodes can be treated by surgery alone without chemo and radiotherapy especially in the early stages cervical cancers. Additional research in this field will give more light and information in this field.
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PMID:[Role of laterally extended parametrectomy in the surgical treatment of cervical cancer stage IB with lymph node metastases (summary of own and foreign experience)]. 1567 50

From 2000 till 2005 were retrospectively analyzed 150 cases with cervical cancer stage I B. All patients were operated by radical hysterectomy type I - III with lymph mode dyssection. In 120 patients the lymph modes were negative. 30 patients had GOG Score of > or = 120. The histology of 23 patients was squamous and for 7 patients adenocarcinomas. All tumours were with invasion of outer third of the cervix. With exception of 2 patients all had lymph-vascular space invasion. In all 30 high risky patients with negative lymph nodes was used small field of postoperative radiation (dose 50-60 Gy). The patients were followed median for 40 months, as we had only 2 patients with recurrence (6%). We did not have ileus, fistulas or any other complications. By resection of the bulky lymph nodes we converted the risky patients with macro metastases into patients with micrometastases. In the postoperative period we used small field of pelvic radiation. All this lead to less complications, less recurrences and better quality of life for these patients.
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PMID:[Some new aspects of the treatment for cervical cancer of I B2 stage]. 1663 14

A 26-year-old patient underwent pelvic lymphadenectomy and trachelectomy because of cervical cancer stage IB. Later she developed symptoms from obturator nerve entrapment. Examinations could not reveal metastatic cancer disease, but endometriosis surrounding the obturator nerve was discovered. Laparoscopic removal of the endometriotic tissue surrounding the nerve was performed and the patient's symptoms then disappeared.
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PMID:Endometriosis entrapment of the obturator nerve after previous cervical cancer surgery. 1843 90


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