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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hypernephroma is one of the most common visceral adenocarcinomas which metastasize to the head and neck. The metastasis may precede discovery of the primary or follow it. The most common sites of metastatic hypernephroma to the head and neck are the sinonasal tract, skin, cervical lymphatics, and mandible. Three cases of metastatic hypernephroma are presented and one of these is the first documented report of a metastasis to the parotid gland. The other two were found in the sinonasal tract.
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PMID:Metastatic hypernephroma to the head and neck. 126 21

Eight cases of metastatic hypernephroma to the head and neck are presented with CT documentation. Hypernephroma is the third most common infraclavicular tumor to metastasize to the head and neck. Such metastases occur in about 15% of patients with this neoplasm, and nearly 8% of patients with this tumor present with disease in the head and neck region. These metastases are usually vascular and may either clinically precede the diagnosis of the renal primary tumor or may occur many years after apparently successful surgery of the primary tumor. These unusual patterns of behavior are reviewed. One of the cases presented here is the first reported incidence of cervical lymph node metastasis with hemorrhage to be documented by CT, thus adding this entity to the list of imaging differential diagnoses of cystic-appearing neck masses.
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PMID:Metastatic hypernephroma to the head and neck. 312 May 36

Between 1975 and 1985 76 patients underwent surgery of pulmonary metastases in our hospital. Most often the primary tumor was located in carcinomas of the colon and rectum (19 patients), followed by carcinomas of the kidney (14 patients), the breast (13 patients) and the skin (malignant melanoma: 9 patients). Conditions for pulmonary metastasectomy are radical removal of the primary tumor, metastases located only in the lung, resectability of the metastases and low operative risk. Three years after pulmonary metastasectomy 35% of the patients were still alive, the 5 year survival rate was 18%. The median survival time was 22 months. The prognosis in patients with pulmonary metastases is largely dependant upon tumor type. Pulmonary metastases of breast carcinomas and carcinomas of colon and rectum can be treated best by surgical intervention. (5 year survival rate: 35% and 33%). Hypernephroma and malignant melanoma have a 5 year survival rate of 0% and 23%. Other prognostic factors are the number of pulmonary metastases and the disease-free interval between surgery of the primary tumor and pulmonary metastasectomy. Furthermore resection techniques are of prognostic importance. Lobectomy and segmental resection showed a better 5 year survival rate than pneumonectomy (21%, 24%, 0%). Median sternotomy is recommended as standard access for pulmonary metastasectomy. Surgery of pulmonary metastases is encouraging.
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PMID:[Surgery of lung metastases]. 338 3

In a retrospective study of 172 patients with disseminated carcinoma in the skeleton, 54% were shown by radiography and scintigraphy to have vertebral metastases. Breast carcinoma was the most common primary tumour, occurring in 30% of the patients, followed by lung (17%), prostate (10%) and kidney (9%). The lumbar spine was most often involved and some primary carcinomas showed a predilection for particular spinal segments. Cord compression occurred in 30% of the patients with vertebral spread and was a poor prognostic sign for long-term survival. Hypernephroma was the most common tumour to cause spinal cord involvement. The thoracic segment was the most frequent site of cord compression (43%), and pathological fracture-dislocation was the most common cause (50%).
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PMID:Metastatic carcinoma of the spine. A study of 92 cases. 344 Jun 53

Metastatic bone disease in 322 patients was analyzed to assess the frequency and behavior of disseminated carcinoma to the vertebral column. Breast, lung, and prostate neoplasms were the most frequent tumors of origin in the 55% of patients who had vertebral lesions. The lumbar spine was the site of the greatest number of metastases. Back pain did not occur in 36% of the 179 patients with spinal disease. Cord compression occurred in 20% of the patients with vertebral involvement, and prostate tumors were the most frequent neoplasm to cause epidural spinal cord impingement. Hypernephroma was the most common cancer to present as a neurologic deficit secondary to an undetected primary malignancy.
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PMID:A profile of metastatic carcinoma of the spine. 398

Hypernephromas account for over 90% of the primary malignant neoplasms of the kidney. These tumors present a spectrum of sonographic findings that correlates well with the known angiographic and pathologic characteristics. Ultrasound can be used to indicate that a mass previously seen on intravenous urography is indeed solid. In addition, the echo intensity, homogeneity, and margins of the tumor can be elucidated. Often, a specific diagnosis of renal cell carcinoma can be made based on these findings. Lymphadenopathy, contralateral metastases, as well as simultaneous primary tumors may also be diagnosed. Therefore, ultrasound has a critical role to play in the diagnosis and management of hypernephromas which will be emphasized in this manuscript.
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PMID:Sonography of renal adenocarcinomas. 634 47

Two cases of metastatic renal clear cell carcinoma to the nose and the paranasal sinuses are reported. Case 1 was a 73-year-old man with metastases to the bilateral maxillas and left cervical lymph nodes. These metastatic lesions were surgically eliminated together with the primary renal cancer. Case 2 was a 48-year-old man with a right maxilloethmoidal metastasis. Because of severe repeated bleeding and profound necrosis, conclusive diagnosis was hard to obtain. In both cases primary renal carcinoma was detected after the nasal tumors were confirmed to be a metastatic clear cell carcinoma. Early diagnosis and surgical removals of both primary and metastatic tumors are important to prolong the patient's life. When persistent epistaxis with intranasal necrotic mass occurs, the possibility of metastatic renal clear cell carcinoma should be considered.
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PMID:Renal clear cell carcinoma metastatic to the nose and paranasal sinuses. 713 23

Malignant clear cell tumors of the head and neck are uncommon. Primary tumors may arise from the salivary glands, thyroid gland, or parathyroid glands, while metastatic tumors most commonly arise from the lungs, kidneys, and female genital tract. Renal cell carcinoma is the third most common metastatic tumor to the bone and soft tissues of the head and neck. Despite this, there have been few reported cases of renal clear cell carcinoma metastases to the neck. Here we report a unique case of an otherwise asymptomatic young woman with a left neck mass as the first clinical sign of advanced renal clear cell carcinoma.
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PMID:Renal clear cell carcinoma appearing as a left neck mass. 887 Mar 69

We preset three patients operated on at our hospital with diagnosed metastasis clear cell carcinoma of the kidney to the thyroid gland 5, 6, and 9 years after nefrectomy. Patients were operated on because of nodular goiter and metastases were diagnosed intraoperatively (frozen section) at two cases and postoperatively in the remaining care (diagnosis made by pathologist-microscopic examination). A radical thyroidectomy was employed without chemio- or radiotherapy which is now recommended as a method of treatment of clear cell carcinoma metastasis.
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PMID:[Metastasis of clear cell carcinoma of the kidney to the thyroid gland]. 919 24

An extremely rare case of epithelial-myoepithelial carcinoma (EMC) of a lobar bronchus in a 47-year-old female is reported. Grossly, the tumor formed a polypoid mass obstructing the bronchial lumen. Microscopically, it was composed of two cellular types--epithelial cells with eosinophilic cytoplasm and clear myoepithelial cells. Numerous tubules formed by an inner epithelial and outer myoepithelial layer were found. Focally, the tumor showed solid growth of clear cells. Prominent hyalinization of the stroma was found. The nature of the cells was confirmed by positive expression of cytokeratins and epithelial membrane antigen in epithelial cells and vimentin and smooth muscle actin in myoepithelial cells. Differential diagnosis of EMC includes a broad spectrum of salivary gland-type tumors. Furthermore, metastases of clear cell carcinoma of the kidney or thyroid, clear cell ("sugar") tumor of the lung, glandular form of carcinoid, bronchioalveolar adenocarcinoma with myoepithelial cells and pulmonary adenosquamous carcinoma with amyloid-like stroma must be distinguished from EMC. The tumor has neither recurred nor metastasised, a fact supporting the current opinion, that EMC is a tumor of low grade malignancy.
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PMID:Epithelial-myoepithelial carcinoma of the bronchus. 968 52


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