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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Patients with transitional cell carcinoma of the bladder treated by radical megavoltage X ray therapy are analyzed. There was a significant correlation between tumor T stage classification and the hemoglobin level at the start of radical radiotherapy. A hemoglobin level of 12g/dl or more was associated with a significant improvement in complete local tumor regression at 6 months and durable local tumor control for patients with T3 cancer or a cancer of grade 3 histology. Hemoglobin level did not influence survival for patients with T1 or grade 1 cancer. Those patients with T2-T4 cancer, grade 2-3 cancer, or a cancer of solid or mixed appearance had a significantly better survival probability if their hemoglobin level was more than 13g/dl. Hemoglobin level would appear to exert its influence on survival by an effect on local tumor control. It has no significant independent effect on the hazard of distant metastases.
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PMID:The influence of hemoglobin level on the regression and long term local control of transitional cell carcinoma of the bladder following photon irradiation. 309 14

Of 146 patients with bladder diverticula during a 15-year period 9 had associated transitional cell carcinoma of the bladder: 3 (2 per cent of all patients with diverticula) in the diverticulum, 3 adjacent to the ostium of the diverticulum and 3 remote from the diverticulum. All 3 patients with carcinoma in the diverticulum died of metastases, whereas the other 6 patients survived more than 5 years. We propose aggressive treatment for patients with carcinoma in the diverticulum but we do not recommend routine diverticulectomy in cases of asymptomatic and uncomplicated diverticula.
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PMID:Vesical diverticulum associated with bladder carcinoma: therapeutic implications. 309 64

The results of diagnostic and staging investigations in consecutive cases of invasive transitional cell carcinoma of the bladder are reviewed. Urine culture, urine cytology and intravenous urography had positive results in a high percentage of cases. As diagnostic investigations they are cost-effective but certainly do not remove the obligation to perform cystoscopy and examination under anaesthetic. Isotopic bone scan and liver scan showed metastases in 4 and one cases respectively and only when there were clinical signs of disseminated disease. Chest X-ray showed metastases in one case. These investigations are not cost-effective. Lymphangiography was positive in 12 of the 94 cases and, although expensive (pounds 70), is still a staging investigation of value in planning treatment.
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PMID:Cost-effectiveness of investigations for invasive bladder cancer. 310 33

Clinical and pathologic data of 54 patients with clinically localized transitional cell tumors of the upper urinary tract were reviewed to determine the significance of tumor grade and stage on patient survival. There were 43 tumors of the renal pelvis (one bilateral) and 11 tumors of the ureter. The primary tumor was staged by the new TNM classification into low stage (Ta: limited to mucosa; T1: lamina propria invasion) and high stage (T2: muscularis invasion; T3; invasion beyond the muscularis). Tumors were low stage (Ta/T1) in 28 cases (51.8%) and advanced (T2/T3) in 26 cases (48.2%). Twenty-five of 54 (46.3%) of the patients had low grade (Grades 1 and 2) and 29 of 54 (53.7%) had high grade (Grades 3 and 4) tumors. Median survival for all patients from date of diagnosis was 31 months, with a 5-year survival rate of 45.8%. Grade (low/high) matched stage (low/high) in 45 of 54 patients (83%). Median survival for patients with low grade tumors was 66.8 months compared to 14.1 months in patients with high grade tumors. Median survival for low stage tumors was 91.1 months and for high stage tumors was 12.9 months. These differences in survival related to both tumor stage (P = 0.001) and grade (P = 0.004) were statistically significant by log-rank test. Fourteen of the 54 patients (25.9%) developed local recurrence and 29 (53.7%) developed distant metastases. The lung was the most common site of metastasis. Eighteen patients (33.3%) had or developed transitional cell carcinoma of the bladder, which preceded the diagnosis of transitional cell carcinoma of the upper tract in seven cases and developed subsequently in 11 cases. Primary tumor stage by the new TNM classification is a better predictor of prognosis than tumor grade, although both variables are strongly predictive of patient course and survival. The advantages of the new TNM classification are discussed.
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PMID:Tumor grade and stage as prognostic variables in upper tract urothelial tumors. 316 13

A biopsy of normal-looking mucosa showed mucosal abnormalities in 48.9% of patients with transitional cell carcinoma of the bladder. The presence of dysplasia or carcinoma in situ was significantly associated with grade but not with tumour category. In 100 patients who completed a course of radical megavoltage X-ray therapy, the result of mucosal biopsy gave no significant prognostic information about tumour regression, durable local control, survival or the risk of subsequent metastases.
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PMID:Do normal mucosal biopsies predict prognosis in patients with transitional cell carcinoma of bladder treated by radical radiotherapy? 356 86

Addison's disease is rarely caused by metastatic cancer. We report a unique case of hypoadrenalism owing to metastatic transitional cell carcinoma of the bladder. The relevant literature is reviewed.
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PMID:Metastatic transitional cell carcinoma of the bladder causing Addison's disease. 357 5

Cutaneous metastases from transitional cell carcinoma of the bladder is a rare occurrence. We report on a patient in whom multiple cutaneous metastases developed five months after radical surgery.
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PMID:Cutaneous metastases from transitional cell carcinoma of bladder. 367 86

Although systemic metastases from transitional cell carcinoma of the bladder occur frequently, involvement of the central nervous system is uncommon. We describe a patient with an isolated cerebral metastasis who had previously undergone resection of a Grade III, Stage B2 carcinoma of the bladder. We have been able to find only one previous case report of a solitary intracerebral metastasis from transitional cell carcinoma of the bladder without evidence of primary recurrence or additional sites of spread. Central nervous system metastasis from bladder carcinoma must be considered in the differential diagnosis of solitary intracerebral lesions.
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PMID:Isolated central nervous system metastasis from transitional cell carcinoma of the bladder: report of a case and review of the literature. 371 11

A case of penile metastases secondary to transitional cell carcinoma of the bladder is reported. The patient was treated with chemotherapy and had the longest survival ever reported for this condition: 20 months; this compares favorably with the 4-month average survival of patients treated by surgery and/or radiotherapy.
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PMID:Metastases to the corpora cavernosa from transitional cell carcinoma of the bladder. 372 86

Arterial embolization was performed for the relief of pain in 4 patients with symptomatic osseous metastases associated with extensive soft tissue tumors. Two patients had metastatic transitional cell carcinoma of the bladder and renal pelvis, and 2 had metastatic renal cell carcinoma. Three of the 4 patients experienced significant relief of pain and improved performance status. Decrease of tumor size or healing of osteolytic metastasis did not occur. Errant embolization occurred in one patient but did not become a serious problem. In 3 patients post-infarction pain occurred, but subsided within 36 hours. This therapeutic approach may be useful to control the pain associated with a massive advanced uroepithelial cancer.
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PMID:[Transcatheter embolization in the management of pain from metastatic uroepithelial cancer]. 375 95


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