Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A large number of cells containing large eosinophilic granules in their supranuclear cytoplasm was observed in a well differentiated adenocarcinoma of the stomach and its metastases. These cells were identified as Paneth cells by electron microscopy and by their content of lysozyme. Lysozyme-immunoreactivity was well preserved after fixation of tumor tissue in liquid formaldehyde followed by postfixation in osmium tetroxide. Immunoreactivity at immunoelectron microscopy was confined to the large osmiophilic secretory granules. We conclude that morphologically and biochemically differentiated Paneth cells occasionally occur in neoplasms of the gastrointestinal tract.
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PMID:Identification of neoplastic Paneth cells in an adenocarcinoma of the stomach using lysozyme as a marker, and electron microscopy. 699 10

During the period of 1949 to 1971, 72 patients at this cancer center underwent en bloc multiple organ resection with curative intent for adenocarcinoma of the stomach that had invaded adjacent organs and structures. The over-all five year survival rate was 7 per cent and the operative mortality, 37.5 per cent. Patients with advanced stage tumors did poorly, although relief of symptoms and some prolongation of survival time were evident. Those patients with early staged tumors limited to the stomach and adjacent perigastric lymph nodes had a remarkable salvage rate of 31 per cent for a corresponding operative mortality of 25 per cent. Most of the postoperative complications and deaths occurred in the earlier period of the study and are preventable with present day surgical management; few deaths occurred during the last five years of the study. In the absence of detectable distant metastases, aggressive resection of these tumors is warranted in carefully selected patients with reasonable prospects of cure and palliation.
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PMID:Management by en bloc multiple organ resection of carcinoma of the stomach invading adjacent organs. 720 78

Metastases to the breast from extramammary carcinomas are rare. Only about 200 cases are reported in the literature. Fifteen additional cases are presented here and the literature is reviewed. Two of the patients has primary thyroid carcinoma, two adenocarcinoma of the colon, three bronchogenic carcinoma, four malignant melanoma, one a squamous cell carcinoma of the oesophagus, one an adenocarcinoma of the stomach, one a renal cell carcinoma and one a carcinoid of the terminal ileum. In three cases the breast lesion was the first manifestation of an extramammary cancer. Six of the patients died of disseminated cancer shortly after the breast metastasis was diagnosed. Although breast metastasis may be suspected clinically, exact histological diagnosis is important in order to avoid unnecessary surgical treatment and to guide further therapy.
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PMID:Metastases to the breast from extramammary carcinomas. 731 21

Isolated splenic metastases are uncommon. We report CT and MRI features of an isolated, large, calcified splenic metastasis from a primary adenocarcinoma of the stomach. Presence of a calcified splenic mass with a known primary malignancy of mucinous nature should suggest the diagnosis of splenic metastasis even if it occurs in isolation.
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PMID:Calcified splenic metastasis from gastric carcinoma. 754 32

Thirty-six patients with nonmucinous adenocarcinoma of the stomach, candidates for surgical laparotomy, were studied to evaluate the presence and extent of coagulation disorders in gastric cancer. They were staged according to TNM cancer staging (T: extent of primary tumor; N: lymph node involvement; M: presence of metastases), and a blood sample was collected before surgery. Platelets, platelet factor four (PF4), beta-thromboglobulin (BTG), activated partial thromboplastine time (APTT), prothrombin time (PT), factors five (V) and seven (VII), fibrinogen, cross-linked fibrin degradation products (XDP), fibrinopeptide-A (Fp-A), and antithrombin three (AT III) were assayed. Only fibrinogen, Fp-A, PF4, and factors V and VII were increased in more than 50% of patients. Fibrinogen and Fp-A were positively correlated with T(r = 0.29, p < p < 0.05; and r = 0.35, p < 0.05; respectively), whereas the other parameters did not show any statistically significant relationship with T, N, and M. Considering the subgroups including only the patients with pathological values, Fp-A (31 patients) was positively correlated with N (r = 0.4, p < 0.05), PF4 (25 patients) showed a positive correlation with T and N (r = 0.42, p < 0.05; r = 0.46, p < 0.05; respectively), and a significantly higher median in the presence than in the absence of metastases (median in the M+ subgroup: 42.7 ng/ml, range 38.6 to 102.8; median in the M- subgroup: 33.7, range 20.3 to 85; p < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Usefulness of coagulation markers in staging of gastric cancer. 755 75

Metastatic carcinoma of the ethmoids is very rare. Of the few cases reported in the literature, the majority are renal in origin. Although metastases from the gastrointestinal tract have been reported, there are no known cases of metastases from the stomach. We present a rare case of metastatic adenocarcinoma of the ethmoids in a patient previously treated for adenocarcinoma of the stomach and describe the possible mechanisms of spread. The patient had a craniofacial resection of the tumour but unfortunately died four weeks post-operatively from acute liver failure probably caused by a liver metastasis.
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PMID:Metastatic adenocarcinoma of the ethmoids in a patient with previous gastric adenocarcinoma: a case report. 756 2

The success of surgical treatment of gastric-, colorectal- and pancreatic cancer is often limited due to local recurrence, the development of metastases or peritoneal carcinosis by cells which have been seeded already at the time of operation. Immunocytological methods enable the detection of disseminated cancer cells before their clinical manifestation as demonstrated by this study. Lavage samples from the peritoneal cavity and bone marrow samples from 147 patients with an adenocarcinoma of the stomach, colon and pancreas were investigated with a panel of six different monoclonal antibodies against tumor-associated antigens (CEA, CA-19-9, 19-1A, C-54-0, Ra96) and cytokeratin, respectively. Additionally, 43 patients with benign diseases were investigated as a control group. Micrometastatic cells were detected either in the bone marrow or the peritoneal cavity in 51% of the cancer patients (gastric cancer: 51%, colorectal cancer: 40%, pancreatic cancer: 72%). The occurrence of stained cells in the peritoneal cavity and bone marrow samples correlated with the tumor stage and showed even in about 30% of patients with a stage I tumor positive bone marrow and/or peritoneal cavity samples. No unspecific reactions were found in the control group. The 2-year follow up shows a significant correlation between tumor cell detection and the survival. Our study strongly indicates a clinical benefit of this method in adjuvant therapy concepts.
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PMID:[Immunocytologic detection of micro-metastatic cells in patients with gastrointestinal tumors]. 770 62

The incidence of surgically suspected and microscopically proved lymph nodes from adenocarcinoma of the stomach and the results of systematic lymphadenectomy have been studied and correlated to survival rate of 99.4 percent at a follow-up period of five years in 872 patients who underwent resection as a part of a prospective observational study in carcinoma of the proximal and distal parts of the stomach. Surgeons believe that, in the median, only one-fifth of the patients with and without systematic lymphadenectomy had positive nodes, whereas pathologists found almost three-fourths of positive lymph nodes (72.7 percent) in patients with proximal carcinoma of the stomach as compared with those without systematic lymphadenectomy (30.8 percent). The figures for middle and lower third carcinomas were even higher (63.5 versus 13.9 percent and 75.9 versus 27.1 percent). Positive nodes were most common in the perigastric area and their distribution was clearly related to the site of the tumor. Frequently, however, lymph node groups were involved, far from the primary, that is, along the hepatoduodenal ligament in 9 to 19 percent of patients with carcinoma of the proximal part of the stomach and in 7 to 16 percent of patients with carcinoma of the distal part of the stomach. There were some hints of a better survival rate for patients with systematic lymphadenectomy as compared with those without, only for low stage carcinoma of the stomach (TNM stage IA-IB, p = 0.1157, Breslow). We suggest a more extensive operation with gastric resection, always combined with systematic lymphadenectomy if no distant metastases are found.
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PMID:Lymph node staging in 872 patients with carcinoma of the stomach and the presumed benefit of lymphadenectomy. German Stomach Cancer TNM Study Group. 815 15

A prospectively randomized controlled clinical trial was performed comparing surgical resection and intraoperative radiotherapy (IORT) with conventional therapy in adenocarcinoma of the stomach. Patients in the experimental group underwent gastrectomy, and IORT was administered to their gastric bed (20 Gy using 11 to 15 MeV electrons). Patients in the control group underwent gastrectomy alone for early-stage lesions confined to the stomach (stages I to II) or resection and postoperative external beam radiotherapy to the upper abdomen (50 Gy using 6 to 10 mV photons) for advanced-stage lesions extending beyond the gastric wall (stages III to IV). One hundred patients were screened for the study, of whom 60 were randomized and underwent exploratory surgery. Nineteen patients were excluded intraoperatively because of unresectability or metastatic disease, leaving 41 patients in the study. Seven patients (17%) died of complications. The median survival for patients with tumors of all stages was 25 months for the IORT group and 21 months for the control group (p = 0.99). Locoregional disease failures occurred in 7 of 16 (44%) IORT patients and in 23 of 25 (92%) control patients (p < 0.001). Complication rates were similar between IORT and control patients. Although IORT failed to afford a significant advantage over conventional therapy in overall survival, IORT did significantly improve control of locoregional disease.
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PMID:Randomized trial of intraoperative radiotherapy in carcinoma of the stomach. 841 95

Alpha-fetoprotein (AFP)-producing hepatoid adenocarcinoma of the stomach is a rare and recently discovered entity. We report an unusual combination of hepatocellular carcinoma and hepatoid adenocarcinoma of the stomach with multiple liver metastases. The patient, a 62-year-old Japanese man, was clinically diagnosed as having hepatocellular carcinoma because of the presence of liver tumors, a markedly elevated serum AFP level, and a positive hepatitis C virus (HCV) antibody titer. Autopsy revealed multiple tumors in the liver; one was a primary hepatocellular carcinoma without metastasis, and the others were metastases from latent hepatoid adenocarcinoma of the stomach. In the hepatocellular carcinoma, bile production was observed although the tumor was immunohistochemically negative for AFP. On the other hand, both the primary gastric and metastatic liver hepatoid adenocarcinomas were positive for AFP. Therefore, hepatoid adenocarcinoma of the stomach was responsible for the excessive production of AFP and was the cause of death.
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PMID:Primary hepatocellular carcinoma and hepatoid adenocarcinoma of the stomach with liver metastasis: an unusual association. 876 86


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