Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study includes 194 patients with stage I cervical cancer subjected to surgical therapy. Of 14 pathological factors analyzed, microscopic parametrial involvement (P = 0.001), depth of invasion (P = 0.001), and lymphovascular space invasion (P = 0.029) were found to be the most significant factors for positive pelvic lymph nodes. Combination of significant factors permitted categorization of patients into risk groups with pelvic lymph node metastases ranging from 0.0% to 90.9%.
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PMID:Correlation between pathological risk factors and pelvic lymph node metastases in stage I squamous carcinoma of the cervix: a multivariate analysis of 194 cases. 194 19

Paraaortic lymph node dissection was performed in the treatment of patients with carcinoma of the cervix who were subjected to radical hysterectomy between June, 1982 and March, 1988 at the Department of Obstetrics and Gynecology, Hokkaido University Hospital, Sapporo, Japan. Thirteen out of 246 (5.3%) patients had metastases in the paraaortic lymph node. Of the patients with stage I carcinoma of the cervix, 1.0 per cent had positive paraaortic lymph node. Of the patients with stage II carcinoma, 4.9 per cent had metastases in the paraaortic lymph nodes, and of the stage III patients, 16.7 per cent had positive paraaortic lymph nodes. The incidence of paraaortic node involvement increased along with the advance of the disease. Of the patients with squamous cell carcinoma of the cervix, 4.6 per cent had paraaortic lymph node metastases. Of the patients with adenocarcinoma of the cervix including mixed carcinoma, 6.8 per cent had positive paraaortic node. All the patients with positive paraaortic lymph nodes had metastatic diseases in the pelvic nodes. In addition, the number of groups of positive pelvic nodes in the patients with positive paraaortic lymph nodes was significantly larger than that in those with negative paraaortic nodes. At the time of reporting, seven out of 13 patients with positive paraaortic lymph node have died of the disease. The mean survival period of those seven patients was 14.9 +/- 12.2 (mean +/- SD) months. Of the remaining six surviving patients, three have been doing well for more than three years.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[The incidence and clinical significance of paraaortic lymph node metastases in patients with uterine cervical cancer]. 229 43

Expansive extirpation of the uterus was performed in 726 cases of stage TIbNXMO cervical cancer. 19.3% of 600 cases of pTIb cancer showed metastatic involvement of lymph nodes. Metastases into regional lymph nodes were found to be resistant to preoperative large-fraction irradiation. The long-term results of treatment of 484 patients with pTIbNOMO cervical cancer receiving 3 different treatment modalities (operation alone, surgery + preoperative irradiation and surgery + postoperative distant irradiation) did not show any significant difference. Complications and relapse were rarer in patients who received surgery only. Therefore, expansive extirpation of the uterus unaccompanied by distant radiotherapy should be a method of choice in treatment of stage I cervical cancer (pTIbNOMO).
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PMID:[Optimal treatment modality for patients with stage-I cervical cancer]. 399 57

Approximately 10%-15% of women with stage I cervical cancer have microinvasive lesions (stage IA). In studying these patients, we aim to identify the cancers that have little or no chance of harboring metastatic disease from the primary site. These patients may be treated by more conservative means, thereby lowering morbidity and cost and preserving the women's fertility. The diagnosis of stage I cervical cancer is surrounded by controversies concerning the diagnostic criteria, the low level of agreement among pathologists interpreting the same material, and the limited evidence in the literature for definitions of risk factors. The available information suggests that women with squamous cell lesions that invade at a 3-mm depth or less and who have no evidence of lymph-vascular invasion may be successfully treated with cervical conization. Women with a depth of invasion of more than 3 mm or with lymph-vascular invasion should be treated with methods that address the potential for disease in the lymph nodes and paravaginal tissues.
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PMID:Management of stage IA cervical carcinoma. 902 28