Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A patient with adenocarcinoma of the prostate presented with right upper quadrant abdominal pain and weight loss. Liver biopsy revealed hepatic metastases from prostate carcinoma. A bone scan demonstrated marked uptake of Tc-99m MDP within the hepatic metastases.
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PMID:Accumulation of a bone imaging agent in liver metastases from prostate carcinoma. 622 62

The case of a 66-year-old man with mucinous adenocarcinoma of the rectum with metastases to the liver is presented. Several mechanisms of accumulation of MDP are identified and correlated with CT scan findings.
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PMID:Accumulation of MDP in hepatic metastases from mucinous adenocarcinoma of the colon. 627 41

Employing ROI-technique, a ratio Q was obtained from relating accumulation of 99mTc-MDP at the site of the bone lesion (n = 150) with that of contralateral non-involved osseous areas. Values of Q were correlated with histologic tumor diagnosis, its dignity and frequency. Values of Q of greater than 3.0 were found in 95% of all sarcomas, in 100% of the osteosarcomas but in only 3.8% of all benign bone tumors. Values ranging from 1.0 to 1.2 were exclusively measured in benign tumors (e.g., in 52% of juvenile bone cysts and in 67% of non-ossifying fibromas). Since the threshold--separating benign from malignant lesions--at Q = 3.0 was blurred by tumorlike lesions, metastases and especially by Paget's disease, this method does not precisely predict dignity. However, this method may complement radiographic evaluation with low values supporting the diagnosis of a benign lesion. The combined findings of radiography and these rations gained by nuclear imaging may help determine the pathway of a patient through further diagnosis and treatment.
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PMID:[Value of the "region of interest" technique in the scintigraphic diagnosis of primary bone tumors (author's transl)]. 645 97

The results of 99mTc-methylene diphosphonate 99mTc-MDP scintigraphy in 37 osteosarcoma patients were evaluated. In 11 of 12 patients with pulmonary metastases these were demonstrated by the scintigram. In 2 of these 11 patients the lung metastases could be shown earlier by scintigraphy than by X-ray tomography. Uptake of 99mTc-MDP appeared to be correlated with the formation of osteoid by the tumor. 99mTc-MDP scintigraphy demonstrated metastases not only in the lungs and the skeleton, but also in the lymph nodes and soft tissues. 99mTc-MDP whole-body scintigraphy should be used routinely for the early detection of osteosarcoma metastases.
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PMID:Detection of lung metastases from osteosarcoma by scintigraphy using 99mTc-methylene diphosphonate. 645 35

Bone scanning with 99mTc-EHDP or 99mTc-MDP was compared with skeletal X-ray survey, determination of acid phosphatase levels and clinical symptoms in a consecutive series of 176 patients with prostatic carcinoma. Skeletal metastases were present in 24%. In these metastatic cases 27% had negative radiographics at the time of initial diagnosis, 29% had normal serum acid phosphatase values and 74% had symptoms other than skeletal, which dominated the clinical picture. When bone scanning was negative for metastases such lesions were never detected in the radiographs. Hence, bone scanning was sufficient for the initial diagnosis of skeletal metastases in 55% of cases. When scans were judged as equivocal or positive an X-ray survey should be done. The variations in count density in metastatic disease were followed by visual assessment of serial bone scans. A densitometric method for quantification of the variations was developed as an aid in the evaluation. Serial bone scanning using a quantitative method appears to offer a readily available objective index of early therapeutic response for use in general clinical practice as well as in controlled therapeutic trails.
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PMID:Serial bone scanning in the evaluation of stage and clinical course in carcinoma of the prostate. 693 33

The antitumor activity of a mixture of synthetic N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) and trehalose-6,6'-dimycolate (TDM) (MDP+TDM) in emulsified form was studied in guinea pigs, each with a syngeneic dermal tumor and microscopically detectable metastases in regional lymph nodes. A single intralesional administration of an ultrasonically prepared emulsion containing MDP+TDM in squalane or in mineral oil caused tumor regression and elimination of lymph node metastases. Similar emulsions of MDP+TDM made with squalene or hexadecane were immunotherapeutically inactive.
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PMID:Immunotherapy of experimental cancer with a mixture of synthetic muramyl dipeptide and trehalose dimycolate. 721 89

A case is presented where skeletal metastases from a prostate carcinoma were detected during 99mTc DTPA scintigraphy performed for evaluation of renal function. The lumbar vertebrae in camera field of view were intensely perfused on the arterial phase of the radionuclide flow study. Tracer pooling in these vertebrae, visualized on initial serial images, progressively faded over the 30 minute study. Widespread areas of increased radionuclide uptake, consistent with skeletal metastases, were detected on 99mTc MDP bone imaging performed two days later. Subsequent prostatic biopsy revealed a well differentiated primary adenocarcinoma.
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PMID:Incidental detection of skeletal metastases on technetium-99m DTPA renal scintigraphy. 760 28

Demonstrable parathyroid adenoma in delayed (3-hr) 99mTc-MIBI neck imaging and localization of 201Tl-chloride in brown tumors mimicking skeletal metastases have been reported. Technetium-99m-MIBI scintigraphy is currently the imaging modality of choice for localizing parathyroid tumors in patients with recurrent hyperparathyroidism. This report is a good example of the use of 99mTc-MIBI in the diagnostic work-up of a patient with recurrent hyperparathyroidism, which turned out to be due to parathyroid carcinoma rather than the initial histopathologic diagnosis of parathyroid adenoma. Additionally, the patient's total body 99mTc-MIBI and 99mTc-MDP bone images showed multiple focal lesions in the bone-mimicking metastases.
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PMID:Technetium-99m MIBI uptake in recurrent parathyroid carcinoma and brown tumors. 773 54

Extracolonic manifestations of Gardner's syndrome are common and may precede the detection of colonic polyps. Tc-MDP bone scintigraphy performed on a patient with Gardner's syndrome demonstrated intense uptake of radiotracer within the maxilla and mandible as a result of the dental anomalies associated with this disorder. Nuclear scintigraphy has a role in the imaging of these patients for skeletal anomalies, the detection of thyroid carcinoma, and for skeletal metastases when colon carcinoma is detected.
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PMID:Gardner's syndrome. Case report and discussion of the manifestations of the disorder. 795 41

Seventy-seven adult patients with suspected skeletal metastases were divided into two groups. In group A (n = 30), following intravenous administration of 20 mCi (740 MBq) of technetium-99m methylene diphosphonate (99mTc-MDP), 3- and 24-h scintigraphy of bone lesions was performed. The 24/3 h lesion to bone background radiouptake ratio (RUR) was calculated for each lesion. In group B (n = 47), the same procedure was followed with dexamethasone intervention (10 mg in 24 h) following the 3-h acquisition. In group A, after determination of the critical point, malignant and degenerative bone lesions could be separated with a sensitivity, specificity and accuracy of 0.76, 0.72 and 0.73, respectively. The mean RUR of the malignant lesions was 1.20 +/- 0.23, and that of the benign lesions, 0.95 +/- 0.15. In group B cases, significantly increased sensitivity, specificity and accuracy of 0.87, 0.94 and 0.92, respectively, were found (P < 0.001). The mean RUR of the malignant lesions was 1.48 +/- 0.34, and that of degenerative lesions, 0.88 +/- 0.19. Dexamethasone interventional bone scintigraphy seems to be a new cost-effective method for differentiating malignant from degenerative bone lesions using the RUR.
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PMID:Differentiation of malignant and degenerative bone lesions using dexamethasone interventional 3- and 24-hour bone scintigraphy. 795 46


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