Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Questionnaires were sent to 2,030 dialysis units in Japan in February 1990 to determine the prevalence of renal cell carcinoma in chronic hemodialysis patients. The response rate of 64% covered approximately 65% of the 88,534 dialysis patients in Japan. Renal cell carcinomas were detected in 130 dialysis patients between March 1988 and February 1990. The age of the 130 patients (112 males and 18 females) was 52.6 +/- 10.9 years (mean +/- SD), and the mean duration of dialysis was 106.0 +/- 82.3 months. The clinical diagnosis was based on CT (59 cases) and sonographic examination (48 cases). Only 15 of the patients were symptomatic. The underlying kidney disease was chronic glomerulonephritis in 108 cases. Acquired renal cystic disease was found in 102 of 124 renal cell carcinoma patients (82.3%). Curative nephrectomy was performed in 99 of 129 patients. The mean tumor diameter was 4.2 +/- 2.5 cm, (range 0.5 to 15.0). Bilateral renal cell carcinomas were found in 11 of the 130 patients. Moreover, 19 of 126 patients had metastases. In conclusion, prevalence of renal cell carcinoma in dialysis patients is 41 times higher than that in the general population. In 83.6% of the patients the diagnosis was made by screening tests. Metastasis was observed in 15.1% of patients in this series.
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PMID:Renal cell carcinoma in chronic hemodialysis patients--a 1990 questionnaire study in Japan. 832 Sep 12

Acquired renal cystic disease (ARCD) has a prevalence of up to 90% in patients with endstage renal failure and an uncommonly high potential of developing into renal cell carcinoma. After renal transplantation, regression of an established ARCD is possible, suggesting a protective effect of transplantation against tumors in the native kidneys. Two case reports describing hypernephromas in kidneys with ARCD 3 years after successful renal transplantation are presented. One patient died 6 weeks after nephrectomy due to metastatic disease, although there were no metastases at the time of operation. The other patient lives with no evidence of disease since 10 months. This report confirms the need of annual sonography of the native kidneys also in renal transplant patients with consecutive computed tomography scanning of suspicious lesions.
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PMID:Renal cell carcinoma in acquired renal cystic disease 3 years after successful kidney transplantation. Two case reports and review of the literature. 852 1