Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

There is evidence that patients under 30 years of age with nasopharyngeal cancer present a somewhat different form of disease than patients of the older age group. Serum immunologic reactivity in the former was quantitatively different. Histologically, tumors in the younger age group are always of the undifferentiated type, and clinically, the disease is aggressive, characterized by frequent bone and lung metastases. The lymphatic spread into the mediastinum is accompanied by a paraneoplastic syndrome consisting of finger clubbing and hypertrophic osteoarthropathy, which is reversible after successful therapy. High rates of recovery have been obtained, even in the presence of advanced disease or metastases. This warrants a radical and persistent radiotherapeutic and or chemotherapeutic approach.
 ...
PMID:Nasopharyngeal cancer in patients under the age of thirty years. 20 Mar 38

Nasopharyngeal carcinoma frequently has as its first manifestation cervical lymph node metastases before local symptoms appear. In the Instituto Nazionale per lo Studio e la Cura del Tumori of Milan, routine nasopharyngeal cytology has been carried out on these patients. Positive cytology in 55 cases of undifferentiated carcinoma (83.6%) and positive cytology of biopsies was obtained in 87.3%. The combination of cytology and histology gave a yield of 98.2% positive cases. For squamous carcinomas positive cytology was less frequently obtained, the same as for malignant lymphomas. The cytology of undifferentiated carcinoma has such marked morphological characters that it is very easy to diagnose it in a very high percentage of cases. In the differential diagnosis cytologically it is necessary to bear in mind other neoplasias, in particular some of the malignant lymphomas.
 ...
PMID:[Cytological diagnosis and cytohistological correlations of malignant epithelial tumors of the rhinopharynx]. 119 87

Nasopharyngeal carcinoma (NPC) is a disease with a high potential of distant metastasis, especially to bone and liver. To evaluate the routine use of bone and liver scintigraphy in the evaluation of metastatic disease during the pre-treatment and follow-up period, 112 new cases of NPC were enrolled. The pre-treatment scintigraphs were performed at the time of staging evaluation, while the follow-up ones were performed once a year and whenever clinically indicated. At the pre-treatment period, 3/112 cases showed a true positive result, all at bony sites. At the 3 years follow-up, 10/83 and 8/83 cases respectively showed a true positive result in the bone and liver. All of the positive cases had definite symptoms and signs of metastases, which correlated well with the scintigraphic findings. All without clinical evidence showed a negative finding. Therefore, we conclude that, without clinical indication, routine bone and liver scintigraphy are of limited value.
 ...
PMID:Nasopharyngeal carcinoma: value of bone and liver scintigraphy in the pre-treatment and follow-up period. 166 80

Today, in the treatment of oral cancer, combined resection and reconstructive surgery has shown marked progress. Especially, the surgical procedures of bone graft after mandibulectomy have been seen widespread application. In the treatment of nasopharyngeal cancer, adjuvant chemotherapy after therapeutic dose of irradiation indicates a better survival rate than radiation alone, and in advanced nasopharyngeal cancer, a wide resection is effective for cure. In the surgical treatment of hypopharyngeal cancer, by the immediate reconstruction of pharynx with jejunum, patients can eat orally in a short time. The most important problem in the treatment of head and neck cancer is development of effective chemotherapy against distant metastases.
 ...
PMID:[Recent progress in the treatment of oral and pharyngeal cancer]. 188 78

Nasopharyngeal carcinoma has been reported to have a higher incidence of distant metastases as compared to other head and neck cancers. Distant metastases of nasopharyngeal carcinoma has been reported in the bones, lungs, liver, distant lymph nodes, brain and porta hepatis. This report presents a case of nasopharyngeal carcinoma with secondaries in the extradural space at the thoracic level of the spinal cord which hitherto has been an unreported site.
 ...
PMID:Nasopharyngeal carcinoma with spinal secondaries. 191 52

Abnormal cellular DNA content, a hallmark of malignancy, is known to be an important prognostic factor in many human solid tumors; however, no data have been published on whether cellular DNA content carries prognostic significance for patients with nasopharyngeal cancer (NPC). Archival, formalin-fixed, paraffin-embedded pathology specimens representing pretreatment tissue biopsies from 55 patients (41 men and 14 women) with NPC were analyzed for cellular DNA content in a retrospective fashion from 1968 to 1988. Individual tumors were classified as either lymphoepithelioma, squamous cell, or anaplastic carcinoma, and were staged according to International Union Against Cancer (UICC) criteria. All patients were treated with curative intent using a 4 to 6 MeV linear accelerator to total doses ranging from 50 to 60 Gy in 4 to 6 weeks. The overall 5-year actuarial survival for all 55 patients was 44.4% (men, 41%; women, 52%). Survival by T stage was as follows: T1, 65%; T2, 51%; T3, 36%; and T4, 27%. Similarly, the 5-year survival rate declined as the bulk of nodal metastases increased: N0, 62%; N2, 50%; N3, 37%; and N1, 25%. Patients who had anaplastic carcinoma had a 5-year survival of 73%, those with lymphoepithelioma had a 60% survival, and those with squamous cell cancer (SCC) had a 30% survival. There was a statistically significant difference in 5-year survival between patients with SCC and those with nonkeratinizing histologies (P less than 0.05). In addition, there was a significant association between patients older than 40 years of age with SCC and patients younger than 40 years of age with nonkeratinizing malignancies (P less than 0.01). Of the 55 tumors successfully analyzed, 22 (40%) were diploid and 33 (60%) were aneuploid. The mean coefficient of variation (CV) of all 55 samples was 6.17%. There was no significant difference in 5-year survival between patients with diploid and those with aneuploid tumors (48% versus 42%). Furthermore, there was no statistically significant survival difference between aneuploid and diploid tumors within any one histologic subgroup. There was also no significant survival difference related to the DNA index. The results indicate that the extent of local tumor spread is still the most important prognostic factor for patients treated with radiotherapy for NPC. The data support the conclusion that patients with lymphoepithelioma and anaplastic carcinomas have a superior survival to patients with squamous cell carcinoma.(ABSTRACT TRUNCATED AT 400 WORDS)
 ...
PMID:A clinical and flow cytometric analysis of patients with nasopharyngeal cancer. 220 35

Recent reports have dispelled the previously held concept that head and neck cancer rarely metastases beyond the cervical lymph nodes. Nasopharyngeal cancer has been reported to have a higher incidence of distant metastases compared to other head and neck cancers, the common sites being bone, lung and liver. A case of nasopharyngeal carcinoma presenting as obstructive jaundice because of secondaries at the porta hepatis is presented here.
 ...
PMID:Nasopharyngeal carcinoma with secondaries at the porta hepatis presenting as obstructive jaundice. 231 76

A group of 131 patients with head and neck cancer in Tanzania (group A) is compared with a simultaneously selected group of 318 patients in The Netherlands (group B). In group A, the patients were about a decade younger, had lower frequency of cancer of the larynx and higher of the nasopharynx and the paranasal sinuses; in the 2 latter sites more often of the squamous cell type than in group B. The predominance of nasopharyngeal carcinoma was linked to the predominance of young patients, bilateral lymph node involvement and distant metastases. The tumours in group A tended to be large, often producing severe signs. A possible association is stipulated between the occurrence of tumour of the nasal cavity and the local habit of sniffing tobacco. The survival rate in group A was poorer than in group B except for nasopharynx cancer.
 ...
PMID:Head and neck cancer in Tanzania in comparison with The Netherlands. 235 81

From 1976 to 1982, 78 patients with nasopharyngeal cancer (NPC) were treated with definitive megavoltage irradiation in accordance with a uniform protocol. The results of treatment were analyzed and prognostic factors reviewed. The incidence of primary failures was directly related to the extent of nasopharyngeal disease, since the relapse rate was 11% in T1T2 patients compared with 37.5% in T3T4 patients. Similarly, failure in the neck correlated with the N stage, being negligible for N0 and N1, while 35.7% for N3. The presence of bulky cervical nodes was associated with a higher risk for metastases: hematogenous dissemination occurred in 50% of N3B patients. The histology pattern seemed to significantly affect the ultimate outcome of patients with NPC, since disease-free survival was 65.5% in patients with a diagnosis of undifferentiated carcinoma (UC) and 23.8% in patients with squamous cell carcinoma (SC). The major cause of poor survival in this latter patient group was not only a higher recurrence rate of both primary and nodal disease but a greater incidence of distant metastases as well.
 ...
PMID:Patterns of failure in nasopharyngeal cancer treated with megavoltage irradiation. 308 81

Nasopharyngeal carcinoma is not a disease to be treated primarily by surgery. Radiation is the first choice of treatment. But, once it recurs, a second course of radiation controls only a small portion of the patients, with a high risk of accumulated radiation injury. We discuss the outcome of salvage surgery in nine cases of nasopharyngeal recurrence and 69 cases of neck metastasis that was uncontrolled or had recurred after irradiation was evaluated. A five-year survival rate of 44% for the primary lesions and 49% for the neck node metastases justifies the rationale of surgery on selected cases of radiation failure.
 ...
PMID:Salvage surgery for nasopharyngeal carcinoma. 334 28


1 2 3 4 5 6 7 8 9 10 Next >>