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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Diagnostic accuracy of the cytologic examination or CEA measurement in pancreatic fluid obtained by percutaneous fine-needle aspiration biopsy under ultrasonic guidance, was investigated in 26 patients with histologically proven carcinoma of the pancreas, and the incidence of positive results of cytology and CEA assay were compared in pancreatic fluid obtained by percutaneous fine-needle aspiration biopsy and by endoscopic cannulation of the ampulla of Vater in the same 19 patients. Positive cytologic findings were observed in the fluid obtained by percutaneous aspiration biopsy of 88.5% of the patients with pancreatic carcinoma. The location of the cancer had no influence on the cytology, but positive results were more frequent in patients with distant metastases than in those with localized tumor or locally invasive carcinoma. Positive cytologic results were obtained in the pancreatic fluid obtained by endoscopic cannulation from the ampulla of Vater of only 15.8% of the patients examined by both methods, but percutaneous fine-needle aspiration biopsy significantly increased the diagnostic rate. In the specimens obtained by aspiration biopsy, tumor cells were much more abundant and easily recognizable. When cytologic examination does not provide any evidence of malignancy, measurement of CEA levels in pancreatic fluid is probably useful. Combination of the cytology and CEA assay of the specimens obtained by percutaneous fine-needle aspiration biopsy of the pancreas increased the diagnostic rate to 100%.
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PMID:Cytologic examination and CEA measurement in aspirated pancreatic material collected by percutaneous fine-needle aspiration biopsy under ultrasonic guidance for the diagnosis of pancreatic carcinoma. 686 Nov 5

The Authors report their experience of 13 cases of metastatic carcinoma of the pancreas, diagnosed over 350 pancreatic cancers examined by digestive angiography (4%). The rarity of this localization is emphasized and is affirmed that any organ may cause pancreatic metastasis (liver, bile ducts, oesofagus) although the kidney and the lung are more frequently the original sites. The pancreatic metastases were of different types but the multilocalized or the total forms don't prevail over the single ones. The angiographic modifications induced by these secondary lesions are evident but not characteristic and diagnosis only of pancreatic tumor can be evocated. Therefore digestive angiography is of high diagnostic value in this cases, although histologic examination is necessary to define the metastatic nature of these lesions.
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PMID:[Diagnosis of secondary tumors of the pancreas. Analysis of 13 cases]. 706 25

A case of mucin-positive giant cell carcinoma of the pancreas is presented. Clear cells were a prominent feature of the primary tumor and constituted the majority of the metastatic deposits, a finding not usually associated with pancreatic carcinoma. Results of ultrastructural and histochemical studies are presented, and the significance of a clear cell component in metastases is discussed.
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PMID:Giant cell carcinoma of pancreas with clear cell pattern in metastases. 715 10

In 152 examinations, sonography was found to be a reliable screening method in the follow-up of curative and palliative surgery of carcinoma of the pancreas. By the effected changeover from compound scanning to the high-resolution real-time B-process, it has become possible to recognize at an early date even small locoregional recurring tumours (1.5 cm diameter), metastases of lymph nodes (1-1.5 cm diameter) and hepatic filiae (1.0 cm diameter); it has also been possible to detect typical changes, such as stenoses or thromboses, at the major vessels of the upper abdomen, well in time. If the findings are not clear, CT examination will be mandatory, if necessary in conjunction with bolus injection of a contrast medium. These methods have been able to largely replace the well-known invasive procedures, such as ERCP, angiography and laparoscopy in follow-up controls.
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PMID:[Value of sonography in the control of pancreatic cancer]. 718 96

A case of giant cell carcinoma of the pancreas is reported herein. The patient is a 67-year-old Japanese woman complaining of ascites, general fatigue, loss of weight, abdominal distention, nausea, and vomiting. Cytological diagnosis of ascites revealed adenocarcinoma. At autopsy, a whitish tumor measuring around 5 cm in diameter was found at the head of the pancreas. Metastasis was seen only in the liver. Histological examination displayed bizarre multinucleated giant cells occasionally phagocytosing the tumor cells and neutrophils.
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PMID:Giant cell carcinoma of the pancreas. 723 16

The prognosis of exocrine carcinoma of the pancreas is still quite bad; because of that, total duodenopancreatectomy following the procedure by Fortner has been our surgical approach since January 1978. Since that time surgery of periampullary carcinoma was extended as well in such a way, that first and second order lymph nodes were excised systematically. Following the introduction of these procedures the percentage of patients with exocrine pancreatic carcinoma operated upon rose from 12 to 35%, - the percentage of patients operated upon because of periampullary carcinoma correspondingly rose from 61 to 91% of all patients carrying these tumors. The incidence of lymphogenous metastases was 88% in 17 patients, which had surgery because of ductal pancreatic carcinoma, and 27% in 22 patients with periampullary carcinoma. 29% of patients with pT1-3 tumors and 71% of patients with pT4 tumors did have already lymphogenous metastases. In 22% of the cases, who would have been operated upon by conventional total duodenopancreatectomy metastases were found in the second order lymph nodes which were taken out according to the new more radical surgical approach; the corresponding figure for patients, who were operated upon by partial duodenopancreatectomy was 5%. Mortality of regional partial duodenopancreatectomy was 4% in our series, and mortality after regional total duodenopancreatectomy was similar to that of conventional pancreatectomy without dissection of lymph nodes.
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PMID:[Extended resection of pancreatic and periampullar carcinoma: regional, total and partial duodenopancreatectomy (author's transl)]. 730 May 46

A laryngeal metastasis from pleomorphic carcinoma of the pancreas is described. The patient was a 70-year-old male. The tumour was located on the right margin of the epiglottis. Bilateral neck lymph node metastases were also found. The patient underwent supraglottic laryngectomy, right radical neck dissection and left suprahyoid neck dissection. Following surgery, the patient's general condition deteriorated day by day, and one month after the surgery he died. The autopsy findings demonstrated a big mass of cancer in the pancreatic tail, multiple lymphatic metastases, carcinomatous peritonitis, and possibly a lymphatic spread of the pancreatic cancer to the larynx.
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PMID:Pancreatic cancer with metastasis to the larynx. 743 Jul 80

The diagnostic accuracy of ultrasonically guided biopsy-gun biopsies was assessed in a group of 47 patients with suspected pancreatic carcinoma. A correct diagnosis with the aid of biopsy was obtained in 44 of the 47 patients (94%). In 3 patients with a carcinoma of the pancreas the correct diagnosis was not obtained with the first biopsy. In 2 of these 3 patients, a simultaneous biopsy of a liver metastasis revealed the presence of malignant tumour growth. No major complications occurred. Biopsy-gun biopsy of the pancreas is considered a useful, reliable and non-traumatic method for the diagnosis of pancreatic malignancy. Twenty-five patients with known neuroendocrine tumour disease were biopsied with 1.2 mm and 0.9 mm biopsy-gun needles to evaluate the respective diagnostic accuracy of the 2 needle sizes. The influence of treatment-related fibrosis on the histopathological diagnosis was also evaluated. The overall diagnostic accuracy with the 0.9 mm needle was 69% as compared to 92% with the 1.2 mm needle. This difference, however, seems more related to needle guiding difficulties with the 0.9 mm needle than to insufficient tissue yield. The increased amount of fibrous tissue due to interferon treatment did not seem to negatively influence the diagnostic accuracy. In order to assess the diagnostic accuracy rate for radiologists with different experience of biopsy procedures 175 cases of renal biopsy-gun biopsies were evaluated. No statistical significant difference was found between the different operators. Provided with detailed instruction even operators with limited experience produced biopsy results equal to those of operators with extensive practice in ultrasound-guided biopsies. The automated sampling performance of the biopsy-gun, with a consistent high diagnostic sampling rate (96%), was believed to be responsible for these results. The role of duplex Doppler ultrasound in monitoring interferon treatment-related changes in carcinoid metastases was evaluated. The patients were divided into 4 groups: untreated (n = 10), progressive disease (n = 17), stable disease (n = 20) and objective response (n = 18). No significant differences in Doppler values were found between the groups, and at present duplex Doppler ultrasound does not seem to play a role in the evaluation of tumour therapy in carcinoid patients.(ABSTRACT TRUNCATED AT 400 WORDS)
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PMID:Therapy evaluation and diagnostic accuracy in neuroendocrine tumours: assessment of radiological methods. 750 92

340 autopsy cases of pancreatic carcinoma from hospitals of St. Petersburg (1990-1991) and Petrozavodsk (1981-1990) have been studied (male/female proportion 1.1:1). The pancreatic head was involved in 75% of cases, including the head only in 61.3%, head and body in 12%, total organ involvement in 2.7%. Pancreatic carcinoma was combined with other tumors in 7 cases, including 4 cases of simultaneous combination. Histological types of carcinoma were represented by: adenocarcinoma (75.2%), undifferentiated carcinoma (10.9%), solid cancer (5.8%), mucosal (4.1%), squamous cell carcinoma (1.7%), glandular-squamous cell carcinoma (0.6%). Metastases occurred most frequently in the liver (52.6%) and lymph nodes (44.7%). Jaundice was registered in 39.1% of cases, primarily in cases of carcinomatous head involvement, and in 12.8% without such involvement (most frequently with metastases to the portal lymph nodes of the liver). Diabetes mellitus was diagnosed in 18 (5.3%) patients, but only in 4 of them as a consequence of pancreatic carcinoma. The diagnosis was found missed in 48% of patients.
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PMID:[Clinico-anatomic characteristics of pancreatic cancer]. 767 87

Explorative laparotomy and palliative surgery keep on having the leadership, in the treatment of exocrine tumours of the pancreas, in spite of important diagnostic and surgery progress. The authors have looked at international literature and their own experience, to simplify the choice of better treatment for each patient. They compared the reliability of various diagnostic technologies and different surgery options. Metastasis and lymphatic invasion are limiting factors for surgery; the first lymphatic stage and duodenum fixation still consent curative surgery. Biliary decompression through external catheter or transpapillary endoscopic prosthesis has a primary role in the diagnostic therapeutic decision. The authors preferred to reserve gastro-jejunostomy to patients with duodenum obstruction. They choose an anterior trans-mesocolic gastro-jejunostomy with Roux-en-y reconstruction, with an upper bilio-enteroanastomosis. Pain relief is one of the most important goal in pancreas' cancer: anaesthetic and surgery techniques lead to good and long-standing results. Explorative laparotomy is often the only technique that leads to the final decision about a therapeutic plan, because it shows size, location and characteristic of the tumour and his metastasis in lymphatic and anatomic structures. The integration of metasurgery therapy (chemo-, radio-, hormono ...) allows, together with pain treatment, to improve the results above all the quality of life in carcinoma of the pancreas.
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PMID:[The criteria of choice in the palliative therapy of cancer of the pancreas]. 768 6


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