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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Giant cell carcinoma of the lung is an unusual form of pulmonary malignancy that follows an extremely aggressive clinical course. We report the clinical and roentgenographic manifestations of 14 patients with pathologically proven giant cell carcinoma of the lung, and compare our data to other reports in the literature. Our patients often presented with or developed constitutional or nonthoracic symptoms. This neoplasm was characterized by early evidence of widespread metastases. However, extension of tumor to the chest wall was not as frequent in our series as has been previously described. The survival from the time of diagnosis was extremely short. Any hope of successful treatment of this neoplasm depends on prompt, early diagnosis. Pulmonary giant cell carcinoma should be included in the differential diagnosis of large, round or oval, sharply outlined peripheral lung masses.
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PMID:Giant cell carcinoma of the lung. Clinical and roentgenographic manifestations. 394 50

Giant cell carcinoma (GCC) of the lung is considered an aggressive form of lung cancer. Most patients with GCC have large tumors with widespread metastases on hospital admission. We describe a small GCC in the lower lobe of the right lung. Preoperative aspiration cytology showed numerous bizarre, giant epithelial cells, highly suggestive of GCC. The resected tumor measured 1.2 x 1.0 x 0.7 cm in diameter, with an ill-defined margin. Histologically the tumor was composed of pleomorphic mononucleate or multinucleate giant cells without adenocarcinoma or squamous cell differentiation. The tumor cells were loosely organized and noncohesive or free in the alveolar space. The histology was interpreted as GCC of the lung. The clinicopathologic features of giant cell carcinoma are discussed.
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PMID:Small giant cell carcinoma of the lung diagnosed preoperatively by transthoracic aspiration cytology. A case report. 784 1

Large cell carcinoma is defined as an undifferentiated carcinoma without the characteristic features of squamous cell, small cell, or adeno-carcinomas. Diagnosis is largely based on exclusion of the other cell types of lung cancer by light microscopy. Large cell carcinoma grows rapidly and is usually quite large by the time it is diagnosed. Most of colony stimulating factor-producing lung cancers previously reported are large cell carcinomas. These colony stimulating factors are considered to contribute to the progressive nature of large cell carcinoma. The radiographic appearance of large cell carcinoma is often larger than 4 cm in diameter. The margins of the mass are poorly defined and lobulated while cavitation remains infrequent. Giant cell carcinoma, which is a variant of large cell carcinoma, is a particularly aggressive subtype with a poor prognosis. Metastases occur fairly late in the course of large cell carcinoma. The sites of metastases (brain, bone, adrenal glands, and liver) are similar to those involved with adenocarcinoma, although the gastrointestinal tract metastases are more commonly involved in large cell carcinoma.
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PMID:[Large cell carcinoma]. 1082 61

We present a 72-yr-old woman who underwent surgical resection of a large pancreatic tumor. On preoperative imaging, an intratumoral cavity containing necrotic tissue was noted, mimicking the appearance of a cystic tumor. There was no invasion of adjacent organs nor distant metastasis, and histopathologic examination revealed the tumor to be a giant cell carcinoma. Postoperatively, the patient has been followed for 1.5 yr without evidence of recurrence. Giant cell carcinoma generally is associated with a poor prognosis, and patients usually die within months despite intensive multimodality therapy. Some patients with giant cell carcinomas, however, achieve long-term survival when invasion of adjacent organs and distant metastases are absent. Surgical resection is the appropriate treatment for tumors with these favorable characteristics.
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PMID:Resectable pleomorphic giant cell carcinoma of the pancreas. 1155 35

We present a 72-yr-old woman who underwent surgical resection of a large pancreatic tumor. On preoperativeimaging, an intratumoral cavity containing necrotic tissue was noted, mimicking the appearance of acystic tumor. There was no invasion of adjacent organs nor distant metastasis, and histopathologic examinationrevealed the tumor to be a giant cell carcinoma. Postoperatively, the patient has been followed for 1.5 yrwithout evidence of recurrence. Giant cell carcinoma generally is associated with a poor prognosis, and patientsusually die within months despite intensive multimodality therapy. Some patients with giant cell carcinomas,however, achieve long-term survival when invasion of adjacent organs and distant metastases are absent. Surgicalresection is the appropriate treatment for tumors with these favorable characteristics.
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PMID:Resectable Pleomorphic Giant Cell Carcinoma of the Pancreas. 1275 7