Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The DNA histograms of 57 conservatively resected renal tumors were studied using automated image analysis DNA cytometry (Leytas II). Forty-nine of the analyzed tumors were renal cell carcinomas, six were oncocytomas, one was an angiomyolipoma, and one was a renal cell adenoma. On the basis of their DNA histograms, diploid, tetraploid, and aneuploid tumors could be distinguished. Aneuploid tumors could be subtyped further according to the DNA content of the stem cell line as hyperdiploid, hypertriploid, or hypertetraploid. Eight of the tumors were characterized by a combination of diploid and hypertriploid stem cell lines. During a mean follow-up of 5 years, only the two patients with a pure hypertriploid tumor died of distant metastases. These results indicate that automated DNA image analysis cytometry is able to differentiate among several types of renal tumors with obviously different prognoses.
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PMID:Characterization of conservatively resected renal tumors using automated image analysis DNA cytometry. 171 31

We report the case of a 49-year-old woman with a large renal angiomyolipoma that invaded the liver. In some areas, the tumor had the appearance of a typical angiomyolipoma; however, it also had foci where the spindle cells of the lesion showed marked cytologic atypia and mitotic activity, giving it the appearance of a high-grade sarcoma. Immunohistochemical studies demonstrated expression of vimentin, desmin, and muscle-specific actin by the sarcoma cells; these findings were consistent with leiomyosarcoma. A second, small typical angiomyolipoma was also present in the kidney. In addition, the liver exhibited focal nodular hyperplasia. Three weeks after resection of the primary renal tumor, pulmonary metastases were diagnosed by fine-needle aspiration biopsy. This is the first report of a case of angiomyolipoma with sarcomatous transformation and biopsy-proven metastatic disease.
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PMID:Renal angiomyolipoma with sarcomatous transformation and pulmonary metastases. 192 59

Between 1979 and 1989 21 renal tumors (8 girls and 13 boys) were diagnosed and treated in the Pediatric Hospital of the University of Erlangen. Additionally, there was evidence of nephroblastomatosis in 5 children with Beckwith-Wiedemann Syndrome and hemihypertrophy. One of these infants developed a Wilms' tumor at the age of 3 1/2 years. The most frequent tumor was the Wilms' tumor, which was diagnosed in 14 children. Wilms' tumor are sonographically well delineated, round or oval tumors which often enclose small cysts (72%) but rarely calcifications (5%) and show inhomogenous liver like echogenicity. Metastasis in liver, spleen or abdomen occurred in 2 infants. The most frequent renal tumor in neonates was the mesoblastic nephroma (3 infants). All mesoblastic nephromas were well delineated round tumors with inhomogenous echo-texture and equal or increased echogenicity in comparison to the liver. They often enclosed small cysts but no metastasis or calcifications. Angiomyolipomas of the kidneys could be diagnosed in two children with tuberous sclerosis. These tumors were echogenic nodules spread all over the kidney. We found multilocular nephroblastomas with multiple irregularly delineated cysts in one child. In an other child multiple renal lymphomas simulating solid tumors with liver-like echogenicity could be found.
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PMID:[Ultrasound differential diagnosis of kidney tumors in childhood]. 217 4

A casuistic observation is described, in which 4 primary multiple tumors of various histogenesis were detected on autopsy in a 56-year-old patient. In the upper part of the jejunum, there was a 3 X 4 cm carcinoid of a mixed structure with metastases to the liver. The primary disseminated malignant glomas tumor as multiple interfluent nodes measuring up to 1.0 X 1.5 cm was present in the parietal and visceral peritoneum. A 2.0 X 2.5 x 3.0 cm pheochromocytoma and a 1.5 X 2.0 X 2.5 cm malignant angiomyolipoma were detected in the right kidney. The tumors had a typical histological structure, yet it was indicated that the detection of paragangliomoid sites in the malignant carcinoid slightly made it difficult to differentially diagnose it with the primary disseminated malignant glomus tumor of the peritoneum.
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PMID:[An unusual combination of primary-multiple apudomas and malignant angiomyolipoma of the kidney]. 257 10

Duplex Doppler ultrasound (US) was used in 21 consecutive patients with renal masses, including renal carcinoma (n = 9), metastases (n = 6), lymphoma (n = 4), angiomyolipoma (n = 1), and sarcoma (n = 1). Seven of the nine carcinomas had Doppler shifts of 4 kHz or more and were hypervascular or vascular. These seven masses had significantly higher (P less than .001) Doppler shifts than all the other malignant renal masses, including the two avascular renal cell carcinomas. Correlation with angiographic findings suggests that the high-frequency Doppler signals were associated with arteriovenous shunts. Detection of the high Doppler shift seems to be a promising step in differentiating hypervascular renal carcinomas from other renal tumors.
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PMID:Renal masses: differential diagnosis with pulsed Doppler US. 264 48

The value of T1 and T2-weighted spin echo sequences for making a specific diagnosis of focal renal disease was evaluated in 105 MR examinations. Typically, hypernephromas are characterised by a reduced or only slightly increased T1 or T2 signal, whereas previous bleeding and long-standing abscesses result in increased signal strength, particularly with T2-weighted sequences. In this way, hypernephromas can be characterised; this is not always possible with CT. Angiomyolipomas also have characteristic signals. MR has no advantages in the diagnosis of recent bleeding, acute focal inflammatory lesions, metastases, carcinoma of the renal pelvis or atypical cysts.
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PMID:[Differential diagnosis of focal kidney diseases using nuclear magnetic resonance tomography]. 284 Jul 15

A retrospective review of 6 patients with renal angiomyolipoma treated surgically revealed regional lymph node involvement in 2--an incidence of 33 per cent. The clinical behavior in these patients suggests that nodal involvement is an expression of multicentricity rather than metastatic disease.
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PMID:Multicentric angiomyolipoma: renal and lymph node involvement. 373 12

Retroperitoneal hemorrhage caused by a renal tumor is usually due to a renal cell carcinoma or angiomyolipoma. The authors report a case of computed tomographic (CT) demonstration of renal metastases from choriocarcinoma with an associated perinephric hemorrhage. The CT features indicated the acute nature of the hematoma and its confinement within the extracapsular compartment of the perirenal space.
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PMID:Perinephric hemorrhage from metastatic carcinoma to the kidney. 668 82

Thirty patients with focal renal masses were evaluated on a .12-Tesla resistive magnetic resonance unit using partial saturation and spin echo pulse sequences. A short repetition time (TR = 143 ms) was employed for partial saturation images and a spin echo was present in each case (TE = 10 ms). Additional pulse sequences through regions of interest were also obtained. Fifteen patients had cystic lesions, nine patients had renal cell carcinoma, two had metastatic lesions, one had an angiomyolipoma, and three had focal bacterial infection. Cystic lesions were well circumscribed and demonstrated a range of signal intensities. Small intra-parenchymal cysts were difficult to identify. Renal cell carcinomas demonstrated areas of increased signal using a partial saturation sequence (TR = 143-415 ms, TE = 10 ms). Magnetic resonance imaging accurately detected perinephric extension and vascular invasion in all patients. Metastatic disease to the kidney was uniformly low in signal, in contrast to primary renal cell carcinoma; an angiomyolipoma demonstrated very high signal intensity. Two masses resulting from acute focal bacterial nephritis were uniformly low in signal. One additional case of a more indolent pyelonephritis demonstrated high signal in regions of replacement lipomatosis and low signal in sites of active infection. Magnetic resonance imaging appears to be an accurate way of detecting, identifying, and staging focal renal masses.
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PMID:Focal renal masses: magnetic resonance imaging. 673 18

The differential diagnosis of bilateral solid multifocal intrarenal and perirenal lesions includes neoplastic, infiltrative, inflammatory, and vascular disorders. In a retrospective study 560 solid lesions were examined with cross-sectional imaging modalities (computed tomography (CT), ultrasonography (US), and magnetic resonance imaging (MRI). The results suggest that focal inflammatory disease can often be recognized because the lesions are poorly defined and may show a rather characteristic peripheral rim enhancement following the administration of intravenous contrast. Angiomyolipomas can be accurately diagnosed with CT, MR and US imaging. Because of their unique histomorphology they show fat-equivalent attenuation values at CT, hyperintense signal on T1 and hypointense signal on T2-weighted MR images, and appear homogeneous and hyperchoic with smooth margins at US. By the radiologic appearance alone renal metastases cannot be distinguished from lymphoma or renal cell carcinoma or adenoma. However, when multiple bilateral solid intrarenal or perirenal lesions are found with synchronous metastatic involvement of other organs or occur in the setting of a known primary tumour, the diagnosis of renal metastases is very likely. In the absence of these additional findings, malignant lymphoma has a higher probability. Infiltration of perinephric fat and thickening of the perinephric fascia may occur in inflammatory disease and lymphoma. CT remains the most suitable imaging technique to screen for these additional perirenal and extrarenal findings because of ready availability and relatively short scanning time as compared to MR imaging.
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PMID:Bilateral solid multifocal intrarenal and perirenal lesions: differentiation with ultrasonography, computed tomography and magnetic resonance imaging. 774 16


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