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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Thymic epithelial tumors are mainly consisted of thymoma, thymic carcinoma, and thymic carcinoid. And thymic carcinoma is very rare neoplasm. The classification of thymic carcinoma has remained a subject of controversy for many years. The outline of thymic carcinoma has been clarified by "Atlas of Tumor Pathology: Tumors of the Mediastium (AFIP)" and "Histrogical Typing of Tumours of the Thymus (WHO)" published recently. Squamous cell carcinoma is by far the most common in Japan. Thymic carcinoma is a predilection for male. The peak of age was 40-60 years. Thymic carcinoma already had contiguous invasion around neighbor organs, dissemination, and lymph node metastases or distant metastases at diagnosis. Two third of patients with thymic carcinoma performed surgery, and most of them performed adjuvant radiotherapy or chemotherapy. 5-year survival of thymic carcinoma was 33-50%. Histologic tumor type, type of tumor margin, growth pattern, nuclear atypia, necrosis and mitotic activity were correlated with survival. In this paper thymic carcinoma is reviewed mainly based on recently literatures and results obtained from a questionnaire on thymic epithelial tumors in Japan.
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PMID:[Thymic carcinoma]. 1217 62

Thymic carcinoma is a rare malignancy, which differs from thymoma in that it displays histopathologically malignant features, extensive local invasion, and a substantial potential for metastasis, predominantly to the liver and kidney and rarely to the central nervous system. Most of cerebral metastases are the intraaxial tumor, whereas extraaxial masses mimicking meningioma are extremely rare. A 32-year-old woman who had been treated for thymic carcinoma with multiple bone metastasis including spine and ribs was referred to the neurosurgery department with a diagnosis of right temporal extraaxial mass. Magnetic resonance imaging (MRI) revealed an extraaxial tumor with hemorrhage along the medial margin of tumor. A craniotomy was performed to remove the mass that was located extraaxially. Histopathological and immunohistochemical examination revealed undifferentiated thymic carcinoma with neuroendocrine differentiation. The patient recovered from the preoperative deficits, and local irradiation of 50 Gy was performed. This paper will examine briefly the radiolographic and pathologic characteristics of this unusual lesion. Although extraaxial thymic carcinomas are rare, they should be considered in the radiographic differential diagnosis of dural-based lesions, especially for patients with history of thymic lesions.
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PMID:Thymic carcinoma with brain metastasis mimicking meningioma. 1218 55

A case of thymic carcinoma with rhabdoid differentiation is presented. A 67-year-old man who presented with chest pain and hemoptysis was referred to The University of Texas M. D. Anderson Cancer Center (Houston, TX). Radiologic studies revealed a large anterior mediastinal mass. After the initial biopsy and preoperative chemotherapy, a radical thymectomy revealed a stage III thymic carcinoma with a rhabdoid component. The rhabdoid component was characterized by large cells with an eccentric nucleus, prominent nucleolus, and typical paranuclear cytoplasmic inclusions. Immunohistochemical and electron microscopic studies confirmed the presence of rhabdoid cells with the paranuclear cytoplasmic inclusions staining for both pancytokeratin and vimentin. The patient was given postoperative chemotherapy and radiation. He has since developed metastases to the pelvis and is alive with disease at 20 months of follow-up. To our knowledge, this is the first reported case of thymic carcinoma with rhabdoid features.
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PMID:Thymic carcinoma with rhabdoid features. 1271 36

Brain metastasis from thymic carcinoma is extremely rare, and there is still no consensus regarding the best management of thymic metastasis to the central nervous system. Here, we report the first-known Australian case. A review of the current literature and the characteristics of thymic tumours with brain metastasis indicate that aggressive management may be able to improve long-term outcomes for these patients. A 49-year-old man presented 2 weeks after thoracotomy for thymic carcinoma resection with a 2-day history of headache, right-sided weakness and expressive dysphasia. CT and MR scans revealed two metastatic brain lesions, one within the left frontal lobe with cystic necrosis and haemorrhage, the other deep in the parietal lobe adjacent to the left ventricle with a lesser degree of haemorrhage. The patient underwent frameless stereotactic craniotomy for excision of the frontal lesion. Histopathology confirmed poorly differentiated thymic carcinoma. Post-operatively his weakness and speech improved dramatically, and he was discharged home within a week, with radiotherapy and chemotherapy to follow. However, he represented with rapidly worsening symptoms and died within a week. Thymic carcinoma is a rare tumour, displaying malignant features clinically and histopathologically with local invasion to adjacent organs. Metastasis is predominantly to lung, bone, liver and kidney, with less predilection for the central nervous system. Treatment for thymic carcinoma is multimodal, but outcome remains poor and life expectancy is very short when brain metastasis with haemorrhage is present.
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PMID:Haemorrhagic brain metastasis from a thymic carcinoma. 1473 82

We describe the clinicopathologic findings in a so far unrecognized thymic tumor. The tumor occurred in a 70-year-old woman with respiratory distress but neither myasthenia gravis nor other symptoms. Metastases or another primary tumor were absent. The well-circumscribed neoplasm was located in the thymic region, measured 18 x 12 x 8 cm, and showed a homogeneous, tan-colored, soft cut surface. By histology, the tumor lacked a true capsule and a lobular growth pattern, was almost devoid of stroma, and infiltrated among remnant thymus lobules. The polygonal tumor cells formed solid sheets, trabeculae, or occurred as single cells that resembled hepatocytes. Proliferative activity was low. Portal structures, sinuses, and bile were absent as were areas of conventional thymoma, adenocarcinoma, or germ cell tumor. The tumor expressed cytokeratins 7 and 19, alpha1-antitrypsin, alpha1-antichymotrypsin, and hep-Par-1. Alpha-fetoprotein (AFP), human beta-chorionic gonadotropin (beta-HCG), placental alkaline phosphatase, CD5, CD30, CD31, CD34, CD45, CD68, CD99, S-100, HMB45, desmin, actin, or neuroendocrine markers were not expressed, and intratumorous CD1a+ or TdT+ immature T cells were absent. AFP was repeatedly undetectable in the blood. Mediastinal tumor recurrence was detected 6 months after surgery. Following radiochemotherapy, the patient has remained free of disease for 26 months. We conclude that this tumor is a thymic carcinoma (WHO type C thymoma). A diagnosis of hepatoid yolk sack tumor appears unlikely considering absence of a bona fide germ cell component, lack of AFP expression, and the patient's female gender. Because of its morphologic and immunohistochemical features, we propose the term "hepatoid thymic carcinoma" for this new type of thymic carcinoma.
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PMID:Hepatoid thymic carcinoma: report of a case. 1504 16

Mucoepidermoid carcinoma of the thymus is an unusual, but well-recognized variant of thymic malignant tumors. Its biologic behavior generally depends on the degree of differentiation and the amount of cellular atypia. High grade tumors can be aggressive neoplasms with a tendency to invade and develop metastases. We report on a case of a 53-year-old man, who presented chest discomfort, dyspnea, and weakness. As heart function tests were normal, the patient underwent radiologic examination, which showed a well-demarcated mass in the anterior mediastinum. Histologic examination of the surgically resected mass showed features of a mucoepidermoid carcinoma with associated infiltration of the pleural tissue. Postoperative radiotherapy and chemotherapy were performed, and the patient died two months after initial diagnosis. In case of the absence of metastatic disease or other common primary neoplasms of the thymus, the diagnosis of a mucoepidermoid thymic carcinoma should be taken into consideration, although this tumor is rare.
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PMID:Mucoepidermoid carcinoma of the thymus: a case presentation and a literature review. 1546 5

Severe vertebral body collapse secondary to metastatic disease is considered a contraindication to vertebroplasty by most authors. Resolution of radicular pain after vertebroplasty is also not well reported. A case of successful vertebroplasty of a severe T7 collapse secondary to metastatic thymic carcinoma with an associated posterior cortical fracture of the body that resulted in resolution of axial and radicular pain is described. The patient had near-complete relief of severe axial and radicular pain. Postoperative imaging revealed anterior placement of the cement without leak into the spinal canal or the intervertebral foramen. The objectives are to describe the clinical and radiographic features of the case to support the idea that vertebra plana secondary to metastatic disease may not be a contraindication to vertebroplasty in selected patients. Simple techniques to avoid leak of cement into the spinal canal are also described. Severe vertebral collapse secondary to metastatic fractures may not be a contraindication to vertebroplasty, provided that appropriate measures are taken to place the trocars and to avoid extrusion of cement into the spinal canal.
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PMID:Percutaneous vertebroplasty in vertebra plana secondary to metastasis. 1557 Jan 32

A five-year-old, castrated, male chinchilla rabbit was presented for evaluation of recurrent bilateral exophthalmos. Besides a transient and stress-related exophthalmos with protrusion of both third eyelids, the ophthalmological examination was unremarkable. Plain radiography of the thorax revealed a large precardial mass of soft tissue density. Cytological preparations from the thoracic mass were dominated by small, mature lymphocytes with approximately 10 to 20 per cent lymphoblasts. Computed tomography of the head showed a symmetrical laterodorsal deviation of both eyes without evidence of retrobulbar masses. On necropsy a large cystic mass was present in the cranial thorax associated with severe hydrothorax, hydropericardium and ascites. Histology identified the precardial mass as thymic carcinoma with metastases in the kidneys. This case illustrates the difficulty of diagnosing thymic tumours based on cytological or histological features of the primary tumour alone. To the authors' knowledge, this is the first case of recurrent bilateral exophthalmos associated with a metastatic thymic carcinoma in a pet rabbit.
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PMID:Recurrent bilateral exophthalmos associated with metastatic thymic carcinoma in a pet rabbit. 1611 55

Between January 1993 and December 2004, 68 patients with mediastinal pathology were submitted to diagnosis surgery. All the pathological process were located in the anterior mediastinum, and most of them were malignant (64.1%). The most common pathology was limphoma (26.5%), sarcoidosis (23.5%) and thymomas (23.5%). Seven cases consisted in ganglionar tuberculosis (10.3%), six cases were ganglionar metastases of lung adenocarcinoma (8.8%), and three cases were thymic carcinoma (4.4%). One patient had no definite diagnosis (1.5%). In this experience high diagnosis accuracy (98.5%), and low morbidity were demonstrated. Although the present video assisted thoracic surgery progress and development, mediastinoscopy still remains as a reliable, safe and efficient surgical approach for the diagnosis of mediastinal pathology.
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PMID:[Surgical diagnosis of mediastinal pathology: eleven-years experience]. 1647 61

We report a case of a 75-year-old man having unusual manifestation of thymic carcinoma associated with endobronchial metastases. To our knowledge, endobronchial metastases secondary to thymic carcinoma has not been reported in the literature. On high-resolution computed tomograms, the tree-in-bud centrilobular opacities caused by metastatic cells accumulating within the small bronchioles is indistinguishable from that caused by inflammatory process. Thus, in patients with thymic carcinoma and persistent tree-in-bud centrilobular opacities, endobronchial metastatic disease should be considered.
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PMID:An unusual case of thymic carcinoma with endobronchial metastases manifesting as centrilobular opacities. 1691 73


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