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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors investigated the late results, or survival at 5 years after the intervention, in 170 patients operated for breast cancer. The total number of survivors at 5 years was of 71 patients, of which 78 belonged to stages I and II, and only 3 to stage III. The authors present their personal attitude for such cases, and stress some of the difficulties encountered in the application of complex therapy. Of the late complications noted, which totalled 58 cases, the authors mention generalized carcinomatosis in 17 patients, pleuro-pulmonary metastases in 14 patients and 11 cases of chronic oedema of the arm, or the so-called "thick arm after Halstead operation".
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PMID:[Late results in 170 patients operated on for breast cancer]. 628 87

This study determines the main routes by which cancer cells reach the pia-arachnoid in leptomeningeal carcinomatosis. Twenty-eight autopsy proven cases of pure carcinomatosis of the leptomeninges were reviewed and the collected data were compared to data derived from control groups of cases with lung or breast cancer, with and without central nervous system (CNS) parenchymal metastases. Pathologic and statistical evidence suggests that in most cases of breast or lung cancer pure leptomeningeal carcinomatosis is the result of cancer propagation from vertebral or paravertebral metastases; in most cases of primary gastrointestinal cancer metastasis to the leptomeninges takes place via perineural spaces; and in cases where deep CNS parenchymal metastases are present leptomeningeal carcinomatosis follows cancer metastasis via the arterial route. Direct spread of a primary cancer in proximity to the CNS accounts for a small proportion of cases of cancerous invasion of the pia-arachnoid. It is not certain if metastasis can take place via the choroid plexus or meningeal arteries.
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PMID:Leptomeningeal carcinomatosis. How does cancer reach the pia-arachnoid? 633 71

Two cases of lethal carcinoid neoplasia that involved unusual polypoid intraperitoneal metastases rather than the usual flat, sclerotic foci are reported. This type of intraperitoneal polypoid carcinomatosis should alert both the surgeon and pathologist to the possibility of carcinoid neoplasia.
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PMID:Polypoid peritoneal metastases from carcinoid neoplasms. 647 67

On the basis of 309 cases of visceral cancer with intracranial metastases studied pathomorphologically, the author describes the clinical features of relatively rare forms of intracranial cancer metastasis: those of isolated carcinomatosis of the cerebral dura mater in 14 patients and carcinomatosis of all the three meninges in eight patients constituting 4.5 and 2.6 percent from the total number, respectively. The clinical picture of disease is shown to depend on the form of metastases (nodular or diffuse), their localization on the basal or the convex surface of the cranium and brain, and the phase of disease. Correlation of clinical signs in metastatic isolated carcinomatosis of the dura mater with those of isolated carcinomatosis of the two inner meninges resulted in identifying a series of symptoms differing significantly in frequency. Informative clinical indices permitting differentiation between carcinomatosis of the meninges and intracranial cancer metastases are provided.
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PMID:[Metastatic carcinomatosis of the dura mater of the brain]. 688 Apr 88

We reviewed 33 cases of meningeal carcinomatosis seen at the Mount Sinai Hospital, New York, from 1970 through 1979. The major sources of meningeal disease were carcinoma of the breast (21 cases), carcinoma of the lung (five), and malignant melanoma (five). Seventy-eight percent of the patients had widespread metastases at the time of neurologic diagnosis. A combination of radiotherapy and intrathecal administration of methotrexate was the most successful treatment, and 14 of 22 treated patients showed at least symptomatic improvement; however, mean survival in the most improved group was still less than six months.
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PMID:Meningeal carcinomatosis. 697 12

Metastatic involvement of the spleen is uncommon. Lymphoma is the most common cause of primary and secondary malignant lesions of the spleen, whereas splenic metastases from carcinoma are rare and usually occur in a setting of concomitant carcinomatosis with melanoma, breast, ovary and lung accounting for the principal primary tumors. We report a case of an isolated, focal splenic defect demonstrated by Tc-99m-sulfur colloid scintigraphy which was the only visual evidence of metastatic adenocarcinoma of the colon. To our knowledge this unusual cause of a focal splenic defect on liver-spleen scintigraphy has not been previously described.
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PMID:An unusual cause of an isolated, focal splenic defect demonstrated by liver-spleen scintigraphy. 706 Feb 95

Referring to a recent report given in Acta Chirurgica Scandinavica of 14 cases of acute perihepatitis in young females with genital inflammation, the pathogenesis of which was claimed unknown, a recapitulation is given of previously published investigations on the clinical significance of the absorption of exudates and particulate matters from the peritoneal cavity in man through the lymphatics of the diaphragm. The pathogenesis of metastases in the supraclavicular nodes (Virchow) and of ascites in peritoneal carcinomatosis is mentioned.
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PMID:The phrenic syndrome in salpingitis ("acute perihepatitis") explained by absorption of exudates from the peritoneal cavity through the diaphragm. 723 77

Adenocarcinoma of the prostate commonly metastasizes to lymph nodes and bones, with occasional visceral deposits; lesions in the brain are rare. Although leptomeningeal carcinomatosis secondary to prostatic tumor has been reported, discrete cranial dural metastases from prostatic adenocarcinoma have not been described previously. The case of a patient having a unique adenocarcinoma of the prostate with bone, lymph node, and subdural metastatic lesions is presented.
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PMID:Subdural metastases from prostatic adenocarcinoma. 728 Sep 85

A review of ten years' experience of talc pleurodesis applied to the treatment of permanently recurrent carcinomatous pleural effusions. Twenty six patients aged between 35 and 83 years, suffering from metastatic pleural effusions, underwent pleuroscopy with local anaesthesia followed by powdering with talc, then suction drainage. There were 8 failures (30%), including 4 early deaths and 4 survivals of less than 4 months with no reduction in the effusion. Three results proved to be poor because of early extra-thoracic metastases (11.5%). There were 15 useful results, with drying up without return of the effusion and comfortable survival for 3 months to 7 years, including 8 of more than a year. These figures, somewhat unfavourable in comparison with those found in the recent literature (up to 90% useful results) were biased by the inclusion of patients who were in fact beyond help (excessive age, markedly impaired general condition, too advanced pleuro-pulmonary lesions, multiple metastases) which represent classical contraindications to the use of the talc technique. It emphasizes the best indications, based upon a sufficiently long life expectancy, good local pleuro-pulmonary state, the virtual restriction of malignant disease to the pleura, residual therapeutic possibilities-all conditions frequently found in cases of pleural carcinomatosis of mammary origin.
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PMID:[Indications for intrapleural talc under pleuroscopic control in malignant recurrent pleural effusions. Based on 26 cases (author's transl)]. 731 62

Documenting lymphangitic metastases to the lungs may be therapeutically important. Several techniques have been described to this end. Sputum cytology, the least invasive and expensive, is the most available. It has a role that may be overlooked but that should be emphasized, since abundant malignant cells in sputum may be associated with this pattern of tumor spread. This case is the first, to the authors' knowledge, in which the pathologic findings associated with malignant cells in lymphangitic carcinomatosis were demonstrated in sputum in the absence of tumor mass invasion of large airways.
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PMID:Diagnosis of lymphangitic carcinoma to lung by sputum cytology: case report. 748 25


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