Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Within the framework of a longitudinal study, 127 chimney sweeps from the area of Upper and Middle Franconia (Bavaria, Germany), who had participated in a first medical check-up in 1974, were offered follow-up examinations in 1990. Eighty-one subjects participated in these examinations; in addition individual occupational case histories and medical case histories were obtained for a further 15 and 35 chimney sweeps, respectively. Five test subjects had died before the evaluation deadline (August 15, 1990). The causes of death were a non-Hodgkin's lymphoma, a bladder carcinoma, pulmonary metastases with unknown primary tumour, a suicide and an acute myocardial infarction. Conspicuous results were carcinoma of the oesophagus in one case and leucoplakia of the mucous membranes in the mouth and pharyngeal region in three cases; furthermore one chimney sweep had two haemorrhagic lumps on his vocal cords. Taking into account important non-occupational hazards (alcohol and nicotine abuse) as possible causes of these changes and the lack of relevant occupational exposure to products of incineration over a number of years, none of these cases nor any of the other ascertained results could be considered likely to be causally related to occupational activities. Due to the small number of cases, an epidemiological risk evaluation did not seem useful. Comparison with the results of other chimney sweep studies published in the international literature is not helpful due to the differences in study design, the varying case frequencies, and the different conditions of exposure.
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PMID:Investigations on health hazards of chimney sweeps in Germany: results of a follow-up study. 139 14

A female patient was treated for acute myocardial infarction of atypical course. In the clinical picture attacks of ventricular tachycardia controlled with pharmacological agents prevailed. The patient died with signs of left-ventricular failure. Autopsy demonstrated metastases of renal carcinoma to the myocardium which simulated infarction in electrocardiographic tracings.
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PMID:[A case of metastasis of cancer of the kidney to the heart simulating myocardial infarction]. 262 71

Intrapleural injection of Corynebacterium parvum (CBP) has recently been used for the treatment of recurrent neoplastic pleural effusions and its mechanism of action has been suggested to be either a local fibrosis-stimulating effect or immunostimulation. The case is reported of a patient with pleuritis secondary to metastases of mammary carcinoma, treated with CBP plus methylprednisolone, who died five days after the treatment because of an acute myocardial infarction. The pathologic examination showed fibrinous pleuritis with an interconnecting network between the visceral and parietal pleura.
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PMID:[Anatomical study of the fibrosing action of Corynebacterium parvum in malignant pleural effusion]. 281 62

Two patients were seen with malignant neoplastic emboli to the coronary arteries. One, a 61-year-old woman with a malignant fibrous histiocytoma of the thigh and a solitary pulmonary metastatic lesion, died of an acute myocardial infarction due to a neoplastic coronary embolus after lobectomy. The other, a 51-year-old woman with bronchogenic adenocarcinoma, died of extensive cerebral metastases. At autopsy, she also was found to have had an acute myocardial infarction associated with a neoplastic coronary embolus.
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PMID:Malignant neoplastic emboli to the coronary arteries: report of two cases and review of the literature. 362 54

We describe two cases, hospitalized patients, in whom the activity of creatine kinase (EC 2.7.3.2) isoenzyme-MB was above normal. Both are particularly noteworthy in that creatine kinase-BB and a macro creatine kinase form thought to be type II of mitochondrial origin were also present. The macro creatine kinase component in both cases co-migrated electrophoretically with creatine kinase-MM but was easily identified after the latter was removed by precipitation with M-subunit-specific antibodies. In the first case, the patient had a readily diagnosable acute myocardial infarction while under observation in the cardiac intensive care unit: electrocardiographic changes and the rapid increase and decrease in total creatine kinase were as would be expected. In marked contrast, in the second case, we saw no abrupt changes in either of these characteristics. The latter patient's primary disease was a rectal carcinoma with massive metastases to the liver; however, the presence of abnormally high creatine kinase-MB activity raised the question of possible myocardial infarction.
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PMID:Unusual findings related to atypical creatine kinases in two hospitalized patients. 394 Jul 16

Decapeptide ceruletide (CRL), chemically related to cholecystokinin and gastrin, proved to have remarkable analgesic properties when administered to a group of 22 burned patients, 15 patients with acute myocardial infarction, and 8 patients suffering from pain caused by malignant tumours with metastases. Its effect was such, that many of the patients required no other analgesics (opiates) even after a prolonged administration (up to 10 days) of CRL. In some of the patients a marked euphoria developed. There were no substantial changes in EEG records during CRL administration in 15 controls, among them 4 epileptics. It is probable that CRL helps to activate the internal analgesic system. In the burned patients cortisol, testosterone, renin, prolactin and tri-iodothyronine (T3) levels in serum (plasma) were measured (radio-immunoassays). CRL did not block the stress response (no drop of increased cortisol levels, no increase in low T3 levels), but it modified (influenced) it (drop of the high renin levels, and a tendency to increase the very low testosterone levels). CRL appears to act as an endorphin releaser, as evidenced by the plasma levels of beta-endorphins (quotations). CRL and similar drugs may represent a new, more physiological and probably safer approach to the management of pain.
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PMID:Endorphin releasers: a new possible approach to the treatment of pain after burns--a preliminary report. 631 91

The oncology patient can experience medical or surgical emergencies as a result of effects of the primary tumor, metastases, or systemic effects of the disease. Emergencies unrelated to the primary oncologic diagnosis, such as acute myocardial infarction, drug overdose, or gastrointestinal hemorrhage, also may occur. For this reason routine emergency protocols and diagnostic procedures should be followed in the treatment of oncology patients. We review the major oncologic-related emergencies, including central nervous system and spinal cord compression, airway obstruction, cardiac tamponade, gastrointestinal obstruction, adrenal insufficiency and hypercalcemia, sepsis, and coagulopathies. Medical and surgical emergencies in the oncology patient should be treated aggressively in the emergency department because a determination about the quality of life of the patient, or the reversibility of the acute process, often cannot be answered quickly in the emergency setting.
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PMID:Emergency evaluation of the cancer patient. 646 53

A subjective maximal exercise test was performed in 62 patients, 70 years of age or more, in the third week after an acute myocardial infarction. Forty-two percent of the surviving AMI population in this age group could be tested. The estimated aerobic work capacity of the patients was on the average about 3 mets. Their maximal heart rate was about 70-80% below the normal age predicted maximum. A low increase of the pressure-rate product from rest to maximal exercise and occurrence of major exercise associated ventricular arrhythmias identified a high-risk group of 32 patients with probability of 4.5 year survival of 0.250 vs 0.767 in the remaining patients (P less than 10(-5)).
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PMID:Early post-myocardial infarction exercise testing in subjects 70 years or more of age. Functional and prognostic evaluation. 652 49

Approximately 5% of patients with acute myocardial infarction do not have atherosclerotic coronary artery disease but have other causes for their luminal narrowing. The third part of this three-part review of nonatherosclerotic causes of coronary narrowing focuses on coronary vasculitis, infectious diseases, Kawasaki's disease, metabolic disorders, metastatic disease, and substance abuse (cocaine).
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PMID:Nonatherosclerotic causes of coronary artery narrowing--Part III. 886 40

The interum results of a multicenter study on extended segmentectomy for small lung tumors and the results reported by Lung Cancer Study Group are discussed. The multi-center study was started in 1992. The inclusion criterium was the presence of a peripheral tumor of less than 2 cm in diameter on chest X-ray films. Seventy three patients were initially enlisted for the study, but 18 patients underwent lobectomy instead because of various reasons such as true or false-positive N1 or N2 disease. The remaining 55 patients were enrolled in this study. The lymph nodes around the segmental and lobar bronchi were examined during operation using fronzen section. Dissection or sampling of the mediastinal lymph nodes was documented. The amount of lung tissues resected was actually more than one segment, because the resection line far entered the adjacent one. Five patients died; one due to local recurrence, known to have the close resection line to the tumor and one of acute myocardial infarction, one of cerebral stroke, one for esophageal cancer and one due to pulmonary metastases on the non-affected side, with no evidence of local recurrence except the first patients. The interim results suggest that the extended segmentectomy is suitable for patients with N0 small tumors.
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PMID:[Extended segmentectomy for small lung cancer]. 904 15


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