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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In two groups of patients with malignant melanoma on the lower limb and with metastases in the inguinal lymph nodes the authors followed the time of appearance of lung metastases and the survival time. In one group lymphography of the extremity was performed, the other one served as a control. Tabulated time data were mutually evaluated between the two groups by the parametric T-test and with the aid of the nonparametric Me-test. No significant difference was found between the two groups, not even with 20% probability. Thus, lymphography is not likely to have an influence on deissemination of malignant melanoma.
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PMID:Does lymphography promote dissemination of tumorous disease? 53 Mar 37

Pulmonary metastases from many primary sources were treated by surgery in 42 patients. The seven-year survival rate was 10%. A long time interval between the operation on the primary tumor and the metastatic lung lesion was associated with a better prognosis. The survival rates for patients with carcinomas and sarcomas were nearly equal equal after removal of pulmonary metastases. The patients with melanoma died soon after lung resections. The location of the metastases in the lower lung lobes had a better prognosis than that of metastases in the upper lobes. In this material there was a patient who, after treatment of the primary tumor, needed three thoracotomies to remove eight pulmonary metastases from both lungs. The patient was alive and free from all signs of recurrence 20 years after the first removal of pulmonary metastases.
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PMID:Surgical treatment of pulmonary metastases. 53 53

A 39-year-old man had pain and swelling of the terminal phalanx of a finger. Radiograph was interpreted as osteomyelitis, and amputation through the mid-phalanx was performed. Histology revealed Ewing sarcoma. Lung metastases rapidly developed. Right lung irradiation and systemic chemotherapy, including doxorubicin, were instituted. He developed progressive severe right ventricular failure which was attributed to effects of large pulmonary metastases. Autopsy showed massive right ventricular metastases, the primary pathological cause of the heart failure, without evidence of doxorubicin cardiomyopathy.
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PMID:Ewing sarcoma: phalangeal primary with fatal cardiac metastases. 54 62

The results of radiation therapy in 800 patients with lung metastases of different malignant neoplasms are reported. Metastases were multiple--in 53 cases, single--in 7, solitory--in 14. In 6 patients metastatic nodes were noted in the pleura. Total irradiation was employed (of one lung in 36 patients, of both lungs--in 44). In 15 patients an additional local irradiation of separate metastatic foci was performed. As a result of the treatment an immediate objective effect was gained in 44 of 80 patients (55%), metastases completely disappeared in 12 cases (15%). The period of remission ranged from 1 month to 2.5 years, making 8 months on the average. The data obtained indicate the rationality to further improve the technic concerned and to study simultaneously the opportunities of using radiotherapy, supplemented with the use of different antitumor drugs, taking into account the sensitivity of some or other malignant tumor to them.
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PMID:[Radiotherapy of metastases of malignant neoplasms into the lungs]. 56 Jul 57

The differential distribution of a series of antineoplastic agents in metastatic tissues compared to their respective primary tumors has been investigated in one rat and two mouse experimental tumor systems, ie, the intramuscular Lewis lung carcinoma (3LL) of C57BL/6 mice, which gives rise to spontaneous lung metastases, the intratibial Sarcoma 180 (S180) of CD1 mice, which induces macroscopic metastases to the lymph nodes, and the Walker 256 carcinosarcoma of CD rats, which also metastasizes to the lymph nodes. The results described in this paper show that the concentrations of adriamycin, daunorubicin, cyclophosphamide and its alkylating metabolites, hydroxyurea, 1-methyl-1-nitrosourea, and 6-mercaptopurine are much higher in the pulmonary metastases of 3LL and/or in the lymph node metastases of S180 than the concentrations measured in the primary tumor. In the Walker 256 tumor system the distribution of adriamycin appears to follow the same pattern observed for the mouse tumors. Only for methotrexate (in the 3LL tumor) is the difference in the concentrations at the two sites not so evident. These findings are discussed in relation to the comparatively greater sensitivity of metastases to chemotherapy.
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PMID:Differential distribution of antitumor agents in primary and secondary tumors. 58 98

The authors report the case of a 58-year-old woman suffering from an intra-thyroid metastasis of a carcinoma of the colon for which she had undergone surgery two and a half years previously. This adenocarcinoma was, furthermore, clinically and radiologically "cured". The metastasis was accompanied by a cervical swelling and paralysis of the left recurrent laryngeal nerve, the reason for the consultation. Subsequent examinations revealed multiple lung metastases. Despite combined treatment with radiotherapy and chemotherapy, there was later development of further multiple metastases, in particular cerebral. The authors review the literature concerning this type of tumour. Particular emphasis is placed upon tumours with a high malignant potential, such as the naevo-carcinoma, together with tumours of neighbouring structures, in particular the upper airway and digestive tract, all of which may spread to the thyroid. There have nevertheless been other cases of thyroid metastasis of a carcinoma of the colon. One of the very first was that of Rankin and Fortune, published in 1936.
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PMID:[Intra-thyroid metastasis of a colonic carcinoma (author's transl)]. 60 41

Was aspiration a cause of lung metastases from basal cell carcinoma? We compared our case to prior reported cases with metastases to the lung attributable to aspiration and considered a prior experimental model. We are convinced we have another case of aspiration metastases from basal cell carcinoma, and hereby report "the 92nd known case."
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PMID:Aspiration metastases from basal cell carcinoma: the 92nd known case. 64 75

A study was done on 21 patients who had advanced carcinoma of the prostate (stage D) treated with 1 mg./kg. cis-diamminedichloroplatinum per week for 6 weeks. The infusions were then spaced every 3 weeks thereafter. One patient had never been treated previously and 20 patients were failures of previous therapy with estrogens and/or radiotherapy and/or chemotherapy. A partial objective clinical remission was seen in 9 of the 21 patients (43 per cent). This response lasted from 3 to 14 months, with an average of 5.8 months. The responses were evidenced by a 50 per cent or more decrease of lesions in the liver (2 patients), recalcification of a bone lytic lesion (1 patient), disappearance of positive lymph nodes in the neck (2 patients), disappearance of pleural effusion (1 patient), disappearance of lymphatic block of lower extremities (2 patients) and disappearance of lung metastases and ureteral obstruction (1 patient). Six patients (28.5 per cent) had a complete disappearance of the bone pain and became ambulatory and asymptomatic, 2 patients (9.5 per cent) with bony metastases remained asymptomatic and apparently stable and 4 patients did not respond to treatment and showed progression. Cis-diamminedichloroplatinum seems to be the most effective drug available to date for the treatment of advanced carcinoma of the prostate.
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PMID:Treatment of advanced carcinoma of the prostate (stage D) with infusion of cis-diamminedichloroplatinum (II NSC 119875): a pilot study. 65 Jul 58

Thyroid cancer in childhood is a relatively rare condition. Often it shows biological characteristics different from those seen in adults. Based upon 10 cases in our clinic and 57 cases collected from the Japanese literatures, clinical features, pathology, treatment and prognosis of thyroid cancer in childhood are discussed. Pathogenesis is most likely to be related to hormonal changes during adolescence and previous radiation of the neck region. Cervical lymph nodes swelling was the chief complaint in 84.6 per cent of the cases. On the other hand, pulmonary metastases were recognized in the early stages in 33.5 per cent of the cases. Radical excision of the tumor with modified radical neck dissection is the treatment most frequently employed even in the presence of lung metastases. However, hypoparathyroidism and recurrent nerve injuries should be avoided at all cost in view of long life expectancy and the difficulty in treating them satisfactorily. Prognosis could be as good for children as it is for adults except in cases with early lung metastases.
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PMID:Thyroid cancer in childhood. 65 Oct 22

Data presented show that the cell cycle time of the lung metastases from a B16 melanoma tumor growing in the foot pad of C57 BL/6J mice increases as the size of the metastases increases. This increased cell phase durations of the small metastases being closer to those of the primary tumor. The growth fractions of the primary tumor and of the lung metastases of different sizes are analyzed.
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PMID:Size dependence of cell cycle parameters for lung metastases from B16 melanoma. 65 26


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