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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The distinction between primary salivary gland tumors and metastases of other primary tumors in salivary glands is of special importance for therapy and prognosis. In the files of the Salivary Gland Register, 10,944 cases were collected during 1965 and 1985. Among these cases, there were 108 cases of metastatic tumors to the parotid and submandibular gland. The pathohistological analysis of these tumors revealed the following data: 47 cases (43%) of metastatic tumors were localized in the parenchyma of the parotid gland (37 cases) or of the submandibular gland (10 cases). 61 cases (57%) displayed metastases in the lymph nodes of the parotid gland (38 cases) or of the submandibular gland (23 cases). The sublingual gland was free of metastatic tumors. 65 metastatic tumors originated from primary tumors in the neighborhood (head and neck). 32 tumors were carcinomas of the skin, 17 tumors were melanomas, and 13 tumors were nasopharyngeal cancers. Metastases of thyroid cancers were found in 3 cases. The relative frequency of metastases in the lymph nodes of the salivary glands is due to the intense drainage with lymph vessels and the presence of many lymph nodes which are localized especially in the gland parenchyma or around the parotid gland. 21 metastatic tumors originated from primary tumors distant from the head and neck region. There were metastases of lung cancers (7 cases), renal cancers (6 cases), mammary cancers (6 cases), colonic cancer (1 case) and uterus cancer (1 case). Clear cell carcinomas in salivary gland tissue should always be checked for a metastasis of a primary renal cancer.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Metastatic tumors to the parotid and submandibular glands--analysis and differential diagnosis of 108 cases. 356 40

Thirty-eight women with surgically confirmed periaortic lymph node metastases from cervical or endometrial carcinoma received radiation therapy. The 5-year observed actuarial survival and relapse-free rates were 42% and 41%, respectively. Concomitant peritoneal metastases conferred a bleak prognosis. There were no differences in survival as a function of site of origin, histologic characteristics, or bulk of periaortic metastases. Earlier stage disease tended to have a higher probability of cure. Morbidity was acceptable. The results confirmed the importance of radiation therapy in the management of lymph node metastases in uterine cancer.
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PMID:Radiation therapy of periaortic node metastases in cancer of the uterine cervix and endometrium. 365 86

The technique of combined radiotherapy of uterine cancer is described employing gammatherapy biaxial rotation and the intracavitary gammatherapy using radiotherapeutical catheter apparatus "Selectron" (Holland). At stage I combined radiotherapy irradiation has been applied daily (2 Gy 5 times weekly) with the total dose reaching 18-20 Gy. The treatment stage II involved intracavitary gamma irradiation by "Selectron". Radiation has been carried out in two regimes of dose fractioning: 1) single local dose in point A (5-6 Gy, 2 times a week and 2) single local dose in point A (10-18 Gy, once a week). The total local dose for both variants is 60 Gy (in point A). Irradiation of regional metastases has been carried out on days free from intracavitary gammatherapy, that permitted withdrawal of the primary tumour lesion from the zone of radiation effect. A conventional regime of dose fractioning has been used. Thus, the combined radiotherapy of uterine cancer has provided the total local dose (in point A) 80-90 Gy, and up to 60 Gy in point B. In some cases the stages of treatment were changed, for the bleeding tumours the treatment started with "Selectron" therapy with subsequent irradiation of the small pelvis. The efficiency of treatment has been evaluated in accordance with clinicomorphological data. The tumours with prevailing exophytic forms of growth have exhibited more rapid regression than those with endophytic growth. In majority of cases reactivity has been restricted to catarrhal epitheliitis. Radiation-induced reaction of the adjoining organs was insignificant. The patients' tolerance was satisfactory. Radiation-induced complications have not been registered in the time interval from 6 months to 2.5 years. The complete clinical regression has been observed in 88% of patients, partial regression in 4%, no response in 8%. 80% of patients have survived 1 year without recurrences and metastases, 75% were alive 2.5 years after treatment. Intracavitary irradiation by the 137Cs sources ("Selectron") are no less efficient than 60Co sources. "Selectron" is convenient, adjustable for different irradiation programmes and ensures radiation safety.
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PMID:[The use of the "Selectron" apparatus in the radiotherapy of patients with uterine cancer]. 373 83

Increases in cancer incidence and mortality reflect the larger numbers of elderly in the population. Using a mortality sample of 1891 biopsy-confirmed cancer patients, analyses reveal older breast, prostate, and cervical-uterine cancer victims were more likely to be diagnosed with metastases. Logistic regression analyses of subsamples of breast (N = 224), lung (N = 513), and colorectal (N = 299) cancer patients indicate that age is significantly inversely related to receipt of both subsequent chemotherapy and radiation therapy, controlling for stage of disease and presence of co-morbid disease. Exceptions to this relationship are the use of radiation therapy among nonmetastatic lung cancer patients and all breast cancer patients. The implications of these findings for current cancer control programs are discussed.
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PMID:Relationship between age at diagnosis and treatments received by cancer patients. 403 35

Three hundred and ten patients with carcinoma of the uterine cervix received postoperative radiation therapy and the relationship between the extent of lymph node metastases and the prognosis was analysed. Patients with lymph node metastases showed a markedly lower five-year survival rate (42.1%) than those without such metastases (91.9%). The prognosis for patients with lymph node metastases was inversely correlated to the number of nodes involved. Bilateral lymph node involvement or para-aortic node metastases gave a much poorer prognosis than unilateral involvement. From these data, standardization for postoperative irradiation of cervical uterine cancer were discussed and summarized.
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PMID:[Standardization for postoperative irradiation of cervical uterine cancer]. 407 50

Between 1978 and 1980, 33 patients with cervical cancer, 40 patients with ovarian cancer, and 28 patients with uterine cancer underwent clinical diagnostic staging. Fifty-four patients had bone scans, and 101 patients received liver scans as a part of their staging work-up. No positive bone scan results were found. Eight of 33 patients with Stage IV disease had positive liver scan results consistent with hepatic metastases. Only 1 of 69 patients with Stage I-III disease had a positive test for metastases. While these numbers are small, the authors conclude that bone and liver scanning in asymptomatic patients with early stage gynecologic cancers may not be warranted as staging procedures.
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PMID:The efficacy of radionuclide liver and bone scans in the evaluation of gynecologic cancers. 646 May 53

At the Rostov Research Oncological Institute 49 patients with uterine cancer were tested by endolymphatic infusion with the preliminary estimation of the tumor sensitivity to chemical drugs. To test the efficacy of the treatment applied was cytological control of the uterine aspirate every 5 days after the infusion prior to surgery, and also morphological changes in the removed tumors at different terms after endolymphatic polychemotherapy. After administration of the drugs at 2--5 day a cessation of the uterine bleeding, lessening or disappearance of pains were noted usually. Among 14 patients with an enlarged uterus as if in the 8--10 week pregnancy, its size was normalized in 11 patients following the treatment. In 5 of 8 patients with parametrial infiltrates the latter completely disappeared while in 3-separated from pelvic walls. Of 3 patients with vaginal metastases the latter disappeared in one case, in 2 cases these were 2/3--1/2 diminished. Total extirpation of the uterus with adnexa was performed in 41 patients, in three of them a histological assay showed no tumor in the removed specimens.
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PMID:[Endolymphatic polychemotherapy in treating cancer of the corpus uteri]. 676 94

Pulmonary metastatic tumors in two patients with locally well controlled uterine cancer were treated with bronchial arterial infusion chemotherapy. The first patient underwent a radical hysterectomy and pelvic lymphadenectomy for stage IIb cervical cancer. Fifteen months after the operation, pulmonary metastasis was identified. Clinical evidence of tumor was negative after bronchial arterial infusion chemotherapy, systemic chemotherapy and radiotherapy. The patient continues to be healthy without recurrent signs six years after bronchial arterial infusion chemotherapy. The second patient underwent a radical hysterectomy and pelvic lymphadenectomy for stage II endometrial cancer. Fifteen months after the operation, pulmonary metastasis was identified. After bronchial arterial infusion chemotherapy and systemic chemotherapy, regression of the tumors was observed. This patient has also survived for two years since the lung metastases. These results indicate that bronchial arterial infusion chemotherapy is a potent treatment for pulmonary metastases of uterine cancer.
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PMID:Successful treatment of metastatic pulmonary tumors by bronchial arterial infusion chemotherapy in two patients with locally well controlled uterine cancer. 804 34

Uterine metastases of malignant tumours are rare. Among extragenital malignancies breast cancers of the lobular type most likely spread out to this site. The respective diagnosis is rendered more difficult by the late onset of clinical symptoms that may imitate the picture of primary uterine cancer. We report on a patient with advanced invasive lobular breast cancer (ILC) where this form of metastazation was detected after conization for PAP IVa. Especially in patients with advanced lobular breast cancer and suspicious symptoms (such as pathologic PAP-Smear, conspicuous colposcopic finding, vaginal bleeding, growth-progressive uterus and hyperplastic endometrium) the possibility of uterine metastases should be included in preoperative planning.
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PMID:[Uterine metastasis of invasive lobular breast carcinoma. Case report and review of the literature with reference to differential diagnostic problems and clinical consequences]. 943 28

Solitary brain metastases from uterine carcinoma are uncommon. Intracranial metastases from uterus usually occur in widely disseminated disease. We report three cases of solitary brain metastasis from uterine cancer. In one of these patients metastasis was detected prior to diagnosis of primitive cancer. In a review of the literature only seven cases of solitary brain metastasis preceding the diagnosis of uterine cancer have been documented.
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PMID:Solitary brain metastases from uterus carcinoma: report of three cases. 1501 83


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