Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Neoplasms of the bovine gastrointestinal tract are rare, possibly because of the low age of the sample population (slaughtered cattle). Forestomach neoplasia (papilloma/squamous cell carcinoma) has a high incidence in cattle from northern England and Scotland because of the mutagenic effects of bracken fern consumption and its interaction with BPV-4. Lymphosarcoma in the abomasum occurs in 41 per cent of cattle with lymphosarcoma, the most common bovine neoplasm in the United States. Small intestinal adenocarcinoma is associated with the papilloma/squamous cell carcinoma complex in the forestomach in England and Scotland, but occurs sporadically in other geographic locations. These lesions may be amenable to surgery, but death from metastatic disease occurs within 1 year. Neoplasms of the large intestine are rarely reported, but usually are adenocarcinoma. Adenoma and fibroma of the rectum may produce clinical signs of tenesmus and rectal prolapse. In general, neoplasia in cattle carries a poor prognosis because of early metastasis of adenocarcinoma and the high fatality of lymphosarcoma. Forestomach fibroma may be treated surgically with success, and palliative surgery for focal small intestinal tumors may be rewarding in individual cases.
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PMID:Neoplasms of the bovine gastrointestinal tract. 220 May 79

The paper is concerned with the analysis of the results of sonographically guided biopsy of hepatic tumors which had been carried out in 30 outpatients suffering primary cancer of the liver (3 cases), metastases (16), lymphosarcoma (2), cysts (2), adenoma (2), hemangioma (4) and hydatidiform mole (1 patient). The sensitivity of the method in tumor diagnosis was 89%, specificity--80%. Ultrasonographic features of the liver pathologies were studied versus morphologic type. Indications and technical requirements for ambulatory ultrasonographically guided biopsy of the liver are discussed.
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PMID:[Ultrasonically guided aspiration biopsy in the diagnosis of liver tumors]. 223 52

Inhibition of experimental metastases of lymphosarcoma LS/BL cells by diltiazem, a calcium blocking agent, was tested. Diltiazem treatment (2 X 30 mg/kg p.o. for 12 days) resulted in a maximum of 72.8% inhibition of liver metastases. The authors suggest that diltiazem might become suitable candidate for antimetastatic treatment in humans.
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PMID:Antimetastatic action of diltiazem on LS/BL tumor cells in liver tumor-colony assay. 237 Sep 18

Intramedullary spinal cord metastasis (ISCM) was diagnosed in three dogs with signs of myelopathy. The clinicopathologic features of ISCM in these and previously reported cases in the veterinary and human literature were compared. Myelopathic signs associated with ISCM may be the initial clinical manifestation of malignancy or may develop in the patient with known malignancy. Pain, a frequent manifestation of extradural compressive myelopathy, is not a consistent feature of ISCM. Survey spinal radiographs are usually unrewarding and cerebrospinal fluid (CSF) abnormalities nonspecific. Myelography is indicated to differentiate intramedullary lesions from more common extradural compressive lesions. Myelographic interpretation may be difficult, and intramedullary tumors must be differentiated from spinal cord edema or hemorrhage. Evidence of widely disseminated malignancy should increase suspicion for ISCM; hemangiosarcoma and lymphosarcoma should be considered the most likely histologic types. CSF cytology may be helpful in the diagnosis of patients with lymphosarcoma. Prognosis is poor due to the frequent presence of disseminated disease, although temporary response to corticosteroid therapy may be achieved. More aggressive therapeutic approaches, such as spinal irradiation and microsurgical resection of metastases, have been advocated in humans but have not been reported in the dog. Although it is an uncommon complication of systemic malignancy, ISCM should be considered in the differential diagnosis of myelopathy in the dog.
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PMID:Intramedullary spinal cord metastasis in the dog. 240 67

Antisera were raised in rabbits against nonmetastasizing (NML) and metastasizing (ML) forms of hamster lymphosarcoma and were purified against normal hamster tissues. Immunoglobulins from the purified antisera were precipitated with 1.6 M ammonium sulfate, radioiodinated and IgG separated by Sephadex G-200 gel filtration. 125I-IgG preparations were analyzed by a direct cell binding assay and by a complement-dependent cytotoxicity test, employing single cell suspensions from primary lymphosarcoma. In some experiments, 125I-IgG was also tested against ML cells obtained from primary tumor (1 degree) and its liver metastasis (2 degrees). NML induced greater anti-tumor antibody production than ML, suggesting greater antigenicity of the non-metastasizing tumor. The two lymphosarcomas appeared to share some common tumor-associated antigens since antibody to one tumor type was either completely or partially absorbed by tumor cells of the other type. Anti-ML 125I-IgG proved up to 2-5 times more cytotoxic for ML 1 degree than 2 degrees cells. Although both tumors were highly tumorigenic in hamsters, only ML gave rise to distant metastases, predominantly in the liver.
Invasion Metastasis 1985
PMID:Antigenic heterogeneity of metastasizing and nonmetastasizing forms of hamster lymphosarcoma: comparison of primary tumor and spontaneous liver metastases. 316 45

The effect of intravenous blood radiation by low-intensity laser on tumour growth in Wistar rats with Pliss lymphosarcoma has been studied. As a result of single or double blood radiation by laser with wave-length of 510 and 633 nm both the tumour growth inhibition and metastases disappearance have been shown.
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PMID:[Effects of intravascular laser irradiation of blood on growth and metastasis of lymphosarcoma in rats]. 319 Dec 41

The motile behavior of two tumor cell variants of the murine BW 5147 lymphosarcoma line, displaying different metastatic capabilities, was analyzed. When placed on top of a confluent monocellular layer of fibroblastic cells, the nonmetastatic lymphoma cells did not carry out any appreciable translocation or shape modification, whereas the metastatic cells displayed intense pseudopodal activity and performed positional shifts. Both these aspects of cell motility were approached through quantitative assays, demonstrating a highly significant difference between the two variant lines. In addition, the metastatic cells were shown to penetrate underneath the fibroblastic monolayer, whereas the nonmetastatic cells were unable to invade. We suggest that the difference in motile behavior is at the basis of the different invasive potencies of the variants. Since in vitro monolayer invasion assays mimic the extravasation of blood-borne cells, we further speculate that in this particular model system, cell motility is the discriminating property that determines whether disseminated tumor formation will occur after intravenous injection of either cell line.
Invasion Metastasis 1988
PMID:Difference in motile behavior between lymphoma variants with different invasive and metastatic capabilities. 334 91

The Abelson-virus-induced murine lymphosarcoma cell line RAW117-P and its in vivo selected highly malignant and metastatic variant RAW117-H10 have been studied for their growth in vivo, in vitro and in semi-solid agar. The highly malignant metastatic variant RAW117-H10 cells killed syngeneic Balb/c mice rapidly and formed 100-200 times more gross liver tumor nodules than the less malignant parental RAW117-P cells. On the other hand, there were no differences between the in vitro growth kinetics of these cells as measured by various parameters such as metaphase arrest or cells in DNA synthetic phase on various days after the initiation of the culture. These cells could be grown in semi-solid agar and formed characteristic colonies. The parental cells formed many very small colonies, whereas the highly malignant cells formed fewer, but very large colonies in soft agar. These results suggest that differential interactions of highly malignant RAW117-H10 cells with the host, particularly the host immune system, are much more important for regulating the number of metastases than any intrinsic growth advantages. It appears that growth differences, potentially based on lack of response to feedback inhibition rather than on kinetic parameters, are responsible for highly malignant RAW117-H10 cells forming larger colonies both in agar in vitro and in the liver in vivo.
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PMID:Differential growth characteristics of low and high metastatic variant RAW117 murine lymphosarcoma cells. 360 20

We have examined whether pertussis toxin, an agent known to inhibit entry of normal lymphocytes into tissues, affects invasion and metastasis formation by malignant lymphoma and T-cell hybridoma cells. The toxin reduced invasion in vitro in hepatocyte cultures to 20% of control values. Inhibition was maximal after pretreatment for 2 h with approximately 100 ng/ml. The effect of pretreatment with 1 to 5 micrograms toxin/ml for 4 h persisted for at least 5 days, despite a more than 100-fold increase in cell number. The proliferation rate was not affected. Liver metastasis formation after tail vein injection of TAM2D2 T-cell hybridoma cells in syngeneic AKR mice, measured as liver weight, was reduced to 10 to 25% of controls after pretreatment of the cells for 4 h with 1 microgram pertussis toxin/ml. Metastasis to kidneys, ovaries, and lymph nodes was not, or less evidently, affected. With MB6A lymphosarcoma cells no effect was seen after treatment with 1 microgram/ml, but a significant reduction of the liver tumor burden to approximately 50% of controls was achieved by treatment with at least 5 micrograms toxin/ml. Spleen metastasis by MB6A cells was not affected. These results provide evidence for a similarity in invasion mechanisms of normal and malignant lymphoid cells, and they suggest that invasiveness is an important factor in the formation of lymphoma metastases, particularly in the liver.
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PMID:Inhibition of lymphoma invasion and liver metastasis formation by pertussis toxin. 365 46

The glycoprotein composition of a transplantable subcutaneous lymphosarcoma (1 degree) and its liver metastases (2 degrees) have been examined in Triton X-100 extracts obtained from tissue, single cells and membrane preparations by using electrophoresis and treatment with radio-labelled lectins. No consistent differences could be detected in the electrophoretic patterns of 1 degree and 2 degrees tumour using RCA-60 or gorse. Small differences were detected using Concanavalin A; all but one of these were eliminated as being due to differential host contamination. A minor band of 178,000 daltons molecular weight was found in 1 degree tissue, cells and membranes that was absent in extracts from 2 degrees tumour. Percoll density gradient separations suggested that this glycoprotein belonged to a small subpopulation of cells; their identity remains uncertain. The band was still detected when tumour was grown from direct liver implants, but it disappeared when this growth metastasized to another lobe. The results provide evidence that metastasis can be accompanied by a very subtle change in the tumour glycoprotein profile. Such a change may have important consequences for host/tumour interactions and subsequent metastatic spread.
Invasion Metastasis 1985
PMID:The binding of ConA and other lectins to surface glycoproteins: a comparison of a subcutaneous tumour and its liver metastases. 383 14


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