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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Heat-killed cells of Mycobacterium bovis (BCG), Mycobacterium phlei and Nocardia rubra were each tested in emulsified form for their ability to cause regression of established dermal transplants and lymph node metastases of a syngeneic hepatocarcinoma in guinea pigs. On a weight basis, BCG was superior to N. rubra in causing tumor regression. Under the conditions tested N. rubra was inferior to M. phlei in its antitumor activity. M. phlei and BCG were approximately the same in their therapeutic potency. In BCG-sensitized guinea pigs, N. rubra provoked a weaker delayed cutaneous hypersensitivity (DCH) reaction than did BCG. In N. rubra-sensitized guinea pigs, BCG provoked a weaker DCH reaction than did N. rubra. Purified protein derivative of M. tuberculosis was more active in eliciting DCH in BCG-sensitized guinea pigs than in animals sensitized with N. rubra.
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PMID:Immunotherapy of guinea pigs with a transplanted hepatoma: comparison of intralesionally injected emulsions containing heat-killed Nocardia rubra, Mycobacterium bovis (BCG) and Mycobacterium phlei. 709 13

Destructive bone lesions in long bones associated with onion like periosteal reaction was found in two girls. Diagnosis of Ewing sarcoma was followed by bone biopsy which indicated eosinophilic granuloma. The radiological appearances of osteomyelitis, tuberculosis, congenital syphilis, Caffey's disease and metastases of neuroblastoma are similar. Bone biopsy is mandatory for correct diagnosis.
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PMID:[Eosinophilic granuloma affecting long bones in children]. 726 80

We report 2 cases of rhabdomyosarcoma of the paratesticular tissues. Differentiation from chronic epididymal infection, such as tuberculosis, may be difficult but it must not delay operation. Lymphography is of limited value in delineating lymph node metastases. In both cases secondary spread was suggested but not confirmed histologically. Lymphography, because of a definite mortality rate of 0.1 per cent and morbidity rate of 1 per cent, would appear not to be indicated.
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PMID:Rhabdomyosarcoma of the paratesticular tissues. 728 56

Cystadenolymphomas (CAL) of the parotid gland are variable in their epithelial differentiation and the ratio of the epithelial tumor component to lymphoid stroma. Two hundred and seventy five cases of CAL from the files of the Salivary Glands Register of the Institute of Pathology, University of Hamburg (1965-1979) were analysed. Their pathogenesis from parenchyma included in regional lymph nodes is discussed. The following subclassification was established. 1. Depending on to the ratio of epithelial tumor component to lymphoid stroma, three subtypes were distinguished. Subtype 1, "typical CAL" with an epithelial tumor component of 50%, amounted to 77% of all cases of CAL studied. Oncocytic differentiation and focal metaplasia to goblet cells or squamous epithelium was also found. 13.5% of CAL were classified as subtype 2, "stroma-poor CAL" with an epithelial tumor component of 70 to 80%. The tumor structure was similar to that of an oncocytoma in places. Two per cent of the CAL were in subtype 3, "stroma-rich CAL" with an epithelial tumor component of only 20 to 30%. Subtype 3 was found solely in men. The average age at presentation (61 years) was slightly lower than that of all the cases studied (65 years). 2. In 7.5% of the cases large areas of squamous cell metaplasia and regressive changes was found within a CAL. These cases were classified as subtype 4 ("metaplastic CAL"). The average age was 67 years. The case histories showed that 20% of these metaplastic CAL had previously been irradiated. 3. Bilateral CAL was found in 7.5% of the cases. In 4% multifocal CAL occurred in the parotid gland unilaterally. Recurrences were observed in 2% of all CAL. 4. Carcinoma in CAL is rare (we found two cases in our own material). In 50% of all cases reported radiotherapy was mentioned in the case histories. 5. Malignant tumors coincident with CAL were recorded in 3% of the cases. 6. The lymphoid stroma showed reaction patterns similar to those of the regional lymph nodes. These included granulomatous changes (foreign body granuloma with cholesterol deposits, tuberculosis) and tumor metastases. In the neighborhood of oncocytic tumor epithelium focal accumulations plasma cells forming IgA and IgG were found. Metaplasia to squamous epithelium is believed to be caused by circulatory disturbances, irradiation, and other noxae. In the differential diagnosis of the stroma-poor subtype 2, oncocytoma and cystic sialadenoma must be excluded, and in the differential diagnosis of subtype 4 (the metaplastic CAL), sebaceous adenoma, mucepidermoid tumor, squamous cell carcinoma, lymphoepithelioma, and other non-tumorous lesions of the parotid gland (lymphoepithelial cysts, myoepithelial parotitis) must be ruled out. Our findings suggest that CAL develops from parenchyma included in parotid lymph nodes with the oncocytic ductal epithelium representing the neoplastic component.
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PMID:Histologic subclassification of the cystadenolymphoma of the parotid gland. Analysis of 275 cases. 746 21

Skeletal tuberculosis (TB) generally involves the spine and large joints. Involvement of most other bones has been reported, but tuberculosis of the pubic symphysis is relatively unusual. This paper reports an unusual case of multiple bone lesions in the right symphysis, left sacroiliac joint and left elbow. The radiologic appearance simulated widespread metastatic disease or chondrosarcoma, but the diagnosis of tuberculosis was proven by biopsy and culture. Eight months after starting antituberculous treatment, the patient experienced an improvement in pain and limping gait, and felt well. Radiography of the pelvis also showed improvement. It is proposed that antituberculous therapy in such cases should be maintained for at least 1 year.
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PMID:Atypical skeletal tuberculosis mimicking tumor metastases: report of a case. 754 69

Contrast enhanced CT manifestations of 141 pulmonary nodules having internal density less than 40 HU were evaluated to study the prevalence of causative disease and their differential points. Tuberculosis (n = 79) was most common, active in 96%. There were 22 cancers, 10 abscesses, 9 paragonimiases, 8 cysts, 7 metastases, 4 aspergillomas without air meniscus sign, and so on. 35% of the benign lesions were greater than 3 cm in diameter and 67% of benign lesions did not show a smooth outer margin. Lung cysts and aspergillomas showed relatively thin peripheral enhanced rim (PER), sharp transitional zone (TZ), a smooth inner border (IB), and homogeneous low densities (LD). Tuberculous nodules tended to be smaller in size with thin PER and most had smooth IB and homogeneous LD. Paragonimiasis, abscess, and cancer tended to present with thick PER and lobulated IB. Lung abscess and paragonimiasis both showed homogeneous LD and narrow TZ. However, in paragonimiasis, multiple locules were seen. Lung cancer showed wider TZ and heterogeneous LD. The size and outer margin of pulmonary nodules as a diagnostic criteria is less useful in LD pulmonary nodule. Therefore, CT can be more useful in differentiating the benign from the malignant lesions by observing a more specific and characteristic pattern of peripheral enhanced rim, transitional zone, inner border, and homogeneity of low density area.
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PMID:The role of contrast enhanced computed tomography in the diagnosis of low density pulmonary nodules. 761 64

Clinical, laboratory, ultrasonic, X-ray, and endoscopic methods were used to specify the cause of macrohematuria from the urinary tract at all levels. Seventy-two patients with macrohematuria were examined; in 37 the process was localizes in the urinary tract (pelvic tumors in 2, calculi in 14, bladder tumors in 9, hemorrhagic cystitis in 2, cystic diverticuli in 3, tuberculosis in 1, prostatic adenoma in 2, prostatic cancer in 4, cases). An ultrasonic examination, though a valuable method, failed to detect papillary tumors of the pelvis when used alone. Transabdominal and transrectal ultrasonic examinations are sufficient to diagnose calculi, diverticuli, or cancer of the bladder, and the advantages of computer-aided tomography over ultrasonic examination in the diagnosis of bladder carcinoma are doubtful. Examination of the prostate by transabdominal and transrectal ultrasonic methods helps to assess its true size and shape, detect changes in these parameters both in prostatitis and in tumors, including metastases of the tumor into adjacent organs and tissues. The problem of recognizing metastases of cancer of the bladder and prostate, when computer-aided tomography and magnetic imaging are of no avail for today, is still to be solved.
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PMID:[Clinical and radiologic diagnosis of etiology of macrohematuria from urinary tract]. 778 97

Positron emission tomography (PET) with fluor-18-labeled deoxyglucose (FDG) enables metabolically oriented imaging of intrapulmonary lesions. PET is currently not used for the detection of lung metastases, but for further diagnostic differentiation of nodules that have already been detected. The diagnostic accuracy of FDG-PET is currently dependent on the size of the metastatic lesions and the uptake intensity. Significantly increased FDG uptake is strongly suggestive of malignant disease whatever the size of lesion concerned. Differentiation of a solitary metastasis from a primary lung tumor is not possible. Slightly elevated FDG uptake can also be found in tuberculosis, sarcoidosis and other granulomatous or inflammatory processes. Exclusion of metastatic disease with PET is currently only reliably possible for lesions larger than 2.0 cm in diameter, owing to respiratory motion and effects of partial volume.
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PMID:[Evaluation of pulmonary lesions with positron emission tomography]. 781 16

The authors reported 8 cases undergone lung limited resections (11 operations) by cavitron ultrasonic surgical aspirator (CUSA). There were 3 cases (6 operations) with multiple metastases in lung, 1 case with single metastasis in lung, 1 case with peripheric lung cancer, 1 case with nodule of tuberculosis in lung, 1 case with lung abscess and 1 case with lung cyst. All the patients recovered well postoperatively. Until now 4 cases with lung metastatic tumors have living well for 3.5, 1, 0.5, and 0.3 years. Ultrasonic Aspiration is very beneficial for lung limited resection: Less blood lose; Simple surgical techniques; and to be able to resect the deep lesions in lung and multiple lung lesions, and avoid lobectomy or pneumonectomy for more preserving lung tissue.
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PMID:[Preliminary experience of use of ultrasonic surgical aspirator for lung limited resection]. 784 31

Fifty-five patients with bone lesions underwent 201Tl-chloride (201TlCl) scintigraphy to evaluate its findings and usefulness for the diagnosis of bone metastases. 201TlCl scintigraphy was performed 15 minutes (early scan) and 2 hours (delayed scan) after intravenous administration of 5.55 MBq/kg of 201Tl-chloride. To evaluate the degree of tracer retention at the lesions, we calculated retention index after setting regions of interest in each lesions demonstrated tracer uptake in both early and delayed scans. Among 118 lesions of pathologically and/or clinically confirmed bone metastases, 201TlCl planar images disclosed 90 (76.3%) and 88% (74.6%) lesions on early and delayed scans, respectively. SPECT images were preferable for the evaluation of the lesions in the spine, the thoracic cage and pelvis. Correlation of tumor size with findings on 201TlCl images demonstrated 90.5% sensitivity for the metastases more than 7 cm3. No correlational difference was seen in the sensitivity depending on primary cancers. The overall retention index of bone metastases was -21.4 +/- 47.1. Bone metastases of pulmonary adenocarcinomas and small cell carcinomas demonstrated higher retention index than those of pulmonary squamous cell carcinomas and breast cancers. On 201TlCl images, no abnormal tracer uptakes were seen in benign lesions detected by 99mTc-hydroxymethylene diphosphonate (99mTc-HMDP) images except 5 lesions. The retention index of these benign lesions demonstrated abnormal uptakes on 201TlCl images was -48.3 +/- 15.0, which found no significant difference between that of metastases. In cases of vertebral compression fractures, abnormal tracer uptakes were demonstrated in 9 of the 12 pathologic fractures against 2 of the 10 benign ones. Those 2 benign fractures proved to be vertebral tuberculosis.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Clinical usefulness of 201Tl-chloride scintigraphy for the diagnosis of bone metastases]. 789 73


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