Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

During the period 1962-1984, 26 cases of synovial sarcoma were seen in the center for bone and soft tissue tumours in Arhus, Denmark. None of the tumours were located in direct relation to bursa or joint cavities and the majority of the patients were initially operated in other hospitals and subsequently referred to the centre. Twenty-three patients were operable. Local excision was the primary treatment in 17 patients and amputation in six patients. Fourteen had local recurrence after an average of 12 months. At the status in June 1987, 14 patients had died of the disease, one survived with metastases to the lungs 30 months after the initial operation, one showed no evidence of disease after approximately three years, six patients were alive and without evidence of disease after at least five years. Five and ten-year survival rates for operable cases were 42% and 31%, respectively.
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PMID:[Synovial sarcoma]. 273 24

Lymph node metastases occur in an appreciable number of soft-tissue sarcomas. The histologic subtype plays a most important role. Synovial sarcoma, malignant fibrous histiocytoma, rhabdomyosarcoma, and angiosarcoma manifest relatively frequently such metastases, whereas fibrosarcoma, liposarcoma, and malignant schwannoma do so very infrequently. With the use of the newer radiologic techniques, it is expected that this feature will be more clearly defined and taken into account in planning the treatment. For histologic subtypes known frequently to manifest metastases to the regional lymph nodes, the latter should be considered for inclusion in the surgical and/or radiation treatment plan, particularly for primary tumors situated close to a nodal basin; and careful follow-up of these nodes should be practiced.
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PMID:Incidence of metastases to lymph nodes from soft-tissue sarcomas. 283 23

To our knowledge, we report the seventh synovial sarcoma of the base of the tongue in the world medical literature. Synovial sarcomas in this location are generally believed to arise from mesenchymal tissue above the hyoid. The surgical and radiation therapy of the primary and various chemotherapeutic programs used in the attempt to control the metastases are outlined. Early surgical therapy followed by radiation therapy before metastases is the best hope for cure.
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PMID:Synovial sarcomas of the tongue base. The seventh reported case. 298 53

Synovial sarcoma, a malignant soft-tissue tumor that occurs primarily in the extremities, is seen rarely in the head and neck. Although known to behave aggressively in the extremities, recent reports suggest that the course of synovial sarcoma may be more indolent when it occurs in the head and neck. Five new cases of synovial sarcoma of the head and neck are described herein. Of four patients with adequate follow-up, three died of pulmonary metastases at 1, 2 1/2, and 8 years following initial treatment. The fourth patient is alive with disease at the primary site six years after diagnosis. The poor prognosis for patients with this disease suggests that aggressive treatment is necessary.
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PMID:Synovial sarcoma of the head and neck. 302 51

Synovial sarcoma of the hand is a very rate tumor in an equally unusual location with a difficult histology of a fibrosarcoma combined with synovial-like areas that resemble joint endothelial lining. It has a poor prognosis prior to the current combined treatment of surgical ablation, radiation to the surgical field, and chemotherapy for microscopic metastases. It has an unexplained natural history of very late recurrence and distant spread, often 10 to 20 years following primary treatment.
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PMID:Synovial sarcoma of the hand. 303 27

The most common soft tissue sarcomas of the hand are epithelioid sarcoma, rhabdomyosarcoma, synovial sarcoma, fibrosarcoma, and clear cell sarcoma. The epidemiology and biology of these tumors are discussed and important unifying concepts, such as local recurrences and regional lymph node metastases, are stressed.
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PMID:Soft tissue sarcomas of the hand. 303 28

From 1964 to 1984, 87 patients with soft tissue sarcoma (excluding lymphreticulum system sarcoma) in the head and neck were treated in our hospital. All were proved by pathology. The incidence rate of fibrosarcoma was the highest (36.8%), hemangiosarcoma the lowest (5.8%). There was no liposarcoma or synovial sarcoma in this group. The most frequently involved site was the area near the nasal cavity and maxillary sinus for fibrosarcoma (66%), the base of tongue for hemangiosarcoma (60%), scalp for dermatofibrosarcoma protuberans (54%), parapharyngeal space and soft tissue of the neck for neurogenic sarcoma (45%). Metastasis rate to the lymph nodes was 16-20% for rhabdomyosarcoma, hemangiosarcoma and malignant fibrohistiocyte tumor. No distant metastasis was found in dermatofibrosarcoma protuberans and malignant fibrohistiocyte tumor. Distant metastasis rate was 10-20% for the other types. Local recurrence rate was 9.1% for dermatofibrosarcoma protuberans, 88.9% for malignant fibrohistiocyte tumor, 30-66.7% for the other sarcomas. The 5- and 10-year survival rates were 20% and 0%, 37.5% and 0%, 91.6% and 91.6% for rhabdomyosarcoma, malignant fibrohistiocyte tumor and dermatofibrosarcoma protuberans. There were differences in clinical behavior for soft tissue sarcomas in the head, neck and in the trunk. Highly malignant sarcomas, such as liposarcoma, synovial sarcoma and rhabdomyosarcoma were rare in the head and neck but the low malignant sarcomas in the head and neck were 3-10 times as common as those in the trunk. Distant metastasis rate of the fibrosarcoma was 20% in head and neck and 6.7%in trunk, the 5- and 10-year survival rates were 36% and 77.9%, 25% and 73.6%, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Soft tissue sarcoma in the head and neck--analysis of 87 patients]. 324 87

A 29-year-old woman with a malignant retroperitoneal hemangiopericytoma which metastasized to both breasts and the lung, is reported. The metastases in the breasts and the lung included numerous glandular structures. The light and electron microscopic, and histochemical analysis confirmed the diagnosis of hemangiopericytoma, and indicated that the glandular component was not a true part of the neoplasm but preformed glandular structures were included. The findings are discussed in relation to previous reports on low-grade leiomyosarcoma with glandular formation in lung metastases. The differential diagnosis against synovial sarcoma, which in monophasic forms may show a prominent pericytoma-like pattern, and in biphasic forms includes pseudoglandular structures, is discussed.
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PMID:Malignant hemangiopericytoma with admixed glandular structures in breast and lung metastases. A light and electron microscopic and histochemical study of a case. 620 62

Synovial sarcoma has been induced in the knee joints of rats by intra-articular injection of 9-10-dimethyl-1-2-benzanthracene. Tumours developed from three to six months after the last injection. The neoplasms obtained were classified as synovial sarcoma (50%), fibrosarcoma (25%), giant cell sarcoma (15%), malignant fibrous histiocytoma (10%). The synovial membrane in the treated knee joints presented a chronic synovitis associated with fibrosis and proliferation of the lining cells. The primitive tumour spread locally infiltrating muscle and the adjacent bones. Metastases occurred most frequently to the lungs (70%) and liver (20%); lymph nodes were involved in 10%.
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PMID:Experimentally induced synovial sarcoma. 626 56

Surgery of soft tissue sarcomas in children has been modified by the introduction of multidisciplinary treatment so that major amputation and exenterations are now rare in the management of these tumors in children. Surgery must still be well planned for total removal of the tumor with preservation of limbs and, in most instances, the function of pelvic organs. The commonest soft tissue sarcomas in children are embryonal rhabdomyosarcoma (RMS), fibrosarcoma, and synovial sarcoma. Treatment of embryonal RMS can now achieve a 2-year survival of 80% at all sites. Surgery and irradiation are used to control the primary tumor and multidrug chemotherapy to control metastases or prevent dissemination of localized tumor. Fibrosarcoma in children, usually a low-grade, extra-abdominal desmoid lesion, does not respond to radiation treatment or chemotherapy, and management is by surgery alone. It shows a marked tendency to local recurrence, and multiple local resections may be necessary for cure. Ninety percent of the children with this tumor can be salvaged by surgery and careful follow-up. The management of synovial sarcoma is surgical and similar to that of RMS. Although not radiosensitive as is RMS, this tumor has responded well to multidisciplinary treatment. Adequate resection is now followed by a chemotherapy protocol similar to that used in osteogenic sarcoma. The smaller numbers of these tumors and their varied natural history make evaluation of treatment difficult. Other soft tissue sarcomas seen with extreme rarity in children are liposarcoma, angiosarcoma, and neurosarcoma. These tumors are treated with the same protocol as that of RMS.
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PMID:Surgery of soft tissue sarcomas in children. 627 15


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