Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 31-yr-old male pseudohermaphrodite is reported with 17 beta-hydroxysteroid dehydrogenase deficiency. Laboratory data revealed a plasma testosterone of 228 ng/100 ml, a plasma androstenedione of 620 ng/100 ml, and an abnormal androstenedione to testosterone ratio. Plasma estradiol was 4.6 ng/100 ml and plasma estrone was 22 ng/100 ml. This subject was born in a hospital, incontrovertibly declared to be a female, and unambiguously raised as a girl by his parents for the first 17 yr of his life. At age 14 yr, he was able to change to a male gender role with ease. As an adult, he is a well adjusted, happily married man with a successful professional career. Surgical correction of bilateral cryptorchidism and hypospadias was carried out at age 14 yr. At age 30 yr, he developed a teratocarcinoma-seminoma of the right testis with retroperitoneal node metastases. After orchiectomy and retroperitoneal node dissection, he was placed on chemotherapy and is presently free of metastases.
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PMID:Male pseudohermaphroditism secondary to 17 beta-hydroxysteroid dehydrogenase deficiency: gender role change with puberty. 46 73

Diagnosis, treatment and follow-up of 8 patients from 1955 to 1975 with extratesticular seminoma are presented. In 5 patients, the neoplasm developed in the mediastinum and in 3 in the retroperitoneum. All the patients were treated by radiation therapy after resection or biopsy. In the entire group, no tumor was diagnosed in the testes. Two patients expired with disease, one after 2 months due to pneumonia, and the other 5 years after diagnosis (10 months after treatment) due to cerebral metastases. Two patients died 12 and 16 years after diagnosis and treatment. At death, they were free of seminoma and the cause of death was a second malignancy. Four patients are alive and healthy, free of disease, 5, 10, 13, and 17 years after diagnosis and treatment. In essence, of the 8 patients, only one actually died of disease, and he was not adequately treated. We feel that this is an entity with an excellent prognosis if adequately and appropriately treated with radiation. We recommend not to perform an orchiectomy when the testes are clinically normal, and to follow the patient closely after treatment.
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PMID:The management of extratesticular seminoma without gonadal involvement. 50 87

In a review of the cases of testicular tumours treated at the Christie Hospital between 1961 and 1974 there are six cases with spontaneous regression of metastases, which are now reported. In this period, 827 cases of testicular tumour have been treated giving an incidence of spontaneous regression of 0.72%, which is considerably higher than previously reported. One of the cases appears to be pure seminoma; spontaneous regression of metastases from seminoma has not been reported previously.
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PMID:Spontaneous regression of metastases from testicular tumours. A report of six cases from one centre. 58

The appearance of calcifications in the site of lymph nodes involved by metastases of seminoma testis and irradiated is described in 2 out 59 patients with abdominal metastases (30 were treated more than 5 years ago and 22 of them are alive without evidence of disease).
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PMID:Lymph node calcification after radiotherapy in 2 cases of seminoma testis. 60 82

An enlarged nodular mass, assumed to be the prostate gland because of location and consistency, was palpated in the pelvic region of a 10-year-old German Shepherd Dog. Castration was performed as a therapeutic procedure after an estrogenic hormone failed to reduce the size of the mass. A tumor identified histologically as a seminoma was in the right testicle. The dog died 1 month after castration, and generalized metastatic neoplasia was observed at necropsy. The mass that involved the neck of the bladder and the metastases were identified as leiomyosarcoma.
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PMID:Leiomyosarcoma of the canine urinary bladder, with metastases. 67 46

With 23 years an embryonal teratoma of the testicles and with 29 years a seminoma was treated by semicastration and post-irradiation or applications of cytostatics. In the two cases 10 or 12 years later seminomas of the other side appeared. Problems of the double-side simultaneous and successive affection are discussed, therapeutic consequences derived and the prognosis is entered. Apart from this the clinical and morphological signs of bilateral metastases of the testicles by a bronchial carcinoma are explained and discussed.
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PMID:[Bilateral testicular neoplasms]. 74 22

One-third of all testis tumors secrete HCG which can be detected in the serum by radioimmunoassay. beta-HCG levels can be used for diagnosis and follow-up of testis tumors. Seminomas with elevated serum beta-HCG levels probably have nonseminomatous metastases.
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PMID:Use of serum beta-chain human chorionic gonadotropin in the management of testis tumor. 74 72

Experience in the treatment of 167 testicular tumors is reported in 164 patients who were hospitalized during the last 15 years. Seminoma patients were irradiated postoperatibely, teratoma patients since 1965 have been subjected to radical lymphadenectomy and also irradiated postoperatively if there was confirmed evidence of metastases. The total survival rate was 58.6 percent. Cytostatic therapy was used in only a few cases: convincing remission could not be observed. The favorable results so far obtained with lymphadenectomy justify the continuation of surgical treatment.
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PMID:[Clinical aspects and treatment of testicular tumors (author's transl)]. 80 41

A 25-year-old man with a seminoma is irradiated several times until the age of 33 for multiple and relapsing metastases. The recovery is maintained for 20 years. The very high total irradiation doses have caused osteonecrotic lesions of the lumbar spine and some functional, but discreet renal problems.
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PMID:20-year survival of seminoma after repeated radiation treatment at 200 kV for abdominal metastases of seminoma: renal and vertebral sequelae. 82 97

From the clinical point of view, histologic classification is intended to give suggestions for therapy (therapeutic classification) and to provide the basis for an assessment of end results (prognostic classification). In adults, the essential therapeutic question is: seminoma (only seminoma) or non-seminoma? The frequency of seminoma among the germinal testicular tumours influenced by the subtlety of the histologic examination. The histologic report should include the MOSTOFI (25) classification and the prognostic group classification of DIXON and MOORE (7). Staging of testicular cancer and criteria for the comparison of treatment results are discussed. The topography of lymphatic metastases of testicular cancer was investigated. The great majority of testicular cancers metastasize regularly, i.e., primarily into the testicular lymph center and/or along the testicular vein, and only secondarily in other lymph nodes. This provides a foundation for the increasing tendency to modified bilateral retroperitioneal node dissection.
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PMID:Testicular cancer, histologic classification and staging, topography of lymph node metastases. 86 89


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