Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Primary lymphoma of the central nervous system (CNS) is difficult to diagnose because of the difficulty in differentiating it from multiple sclerosis, sarcoidosis, metastatic disease, chronic granulomatous disease, and cerebral cysticercosis. With the patient presented in this report, no abnormalities were found after performing laboratory tests, using radiographic modalities, and taking biopsies. Dexamethasone treatment was initiated, and patient's symptoms improved.Primary CNS lymphoma was not diagnosed until a year after presentation, due to lack of tissue diagnosis. CNS must be suspected when a diagnosed tumor treated with steroid is not found at surgery. It is suggested that a computerized tomographic scan be requested before the start of steroid therapy, as the lesion can disappear with steroid treatment.
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PMID:Primary lymphoma of the central nervous system: a diagnostic problem. 356 Feb 50

The lymphographic appearance of lymphoma may be simulated by a variety of other diseases, both malignant and benign, including metastases, lymphangiomatosis, sarcoidosis and lymphadenitis. In addition, non-specific reactive changes of the lymph nodes are common in lymphography of children sometimes simulating lymphoma.
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PMID:Conditions simulating lymphoma in children--a lymphographic study. 362 45

The magnetic resonance characteristics of mediastinal and hilar lymphadenopathy were reviewed in five patients with sarcoidosis and one with Castleman's disease. Although the T1 values of 26 nodes measured in patients with sarcoidosis ranged from 390 to 786 msec (mean 549 msec; SD 88 msec), the mean values recorded for each patient were quite similar (range 501-616 msec). T2 values ranged from 40 to 68 msec (mean 49 msec; SD 7 msec). In the patient with Castleman's disease T1 and T2 values measured 838 msec and 45 msec respectively. In comparison to T1 and T2 values we have recently measured in patients with proven mediastinal lymph node metastases from bronchogenic carcinoma, lymph nodes in the patients with sarcoidosis have significantly lower T1 (p less than .001) and T2 (p less than .05) values. However, because of significant overlap between the values recorded in these two groups, their differentiation may be difficult in individual cases.
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PMID:MR characteristics of benign lymph node enlargement in sarcoidosis and Castleman's disease. 372 Jul 47

We studied the clinical and radiological features of pulmonary metastases present in 4 out of 22 patients with medullary carcinoma of thyroid. Two patients presented with common metastases: macronodules in one, and micronodules in the other one. The other two patients presented initially with reticulonodular perihilar lesions on chest X-ray, leading to the diagnosis of sarcoidosis in both of them. The observation of such pulmonary metastases is original: initially latent, they progress very slowly, and they correspond to a lymphangitic spread of the tumour with amyloid deposition in peribronchovascular structures without alveolar involvement, as shown in one of our cases with pathologic study.
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PMID:[Pulmonary metastases in medullary cancers of the thyroid. Study of 4 cases. Originality of the lymphangitic form with amyloid stroma]. 374 85

The authors retrospectively evaluated the characteristics on magnetic resonance (MR) images of 59 suprasellar lesions and compared them with computed tomography (CT) scans in 55 of the cases in which CT was performed. A diverse number of lesions were included: 17 pituitary adenomas; eight optic or hypothalamic gliomas; six craniopharyngiomas; six vascular anomalies; four lesions with extension into the suprasellar space; three metastases; two each of meningioma, hamartoma, germinoma, sarcoid granuloma, and teratoma; and one each of lymphoma, optic tract hematoma, cerebrospinal fluid-borne metastasis, pituitary hyperplasia, and sphenoid sinus mucocele. MR enabled characterization of lesions containing hemorrhage, fat, flowing blood, mucus, and cyst and allowed more specific diagnoses than CT in 6% of cases. MR was equivalent to CT in allowing lesions to be detected and in 20% of cases more accurately defined altered perisellar anatomy. Vascular abnormalities can be better evaluated with MR, and use of angiography can be avoided in some cases.
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PMID:Suprasellar lesions: evaluation with MR imaging. 376 87

We reviewed the clinical records and over 1900 chest radiographs of 218 patients with carcinoma of the breast. The patients were treated with surgery and radiation therapy. During the two-year follow-up pathological signs were seen in the chest radiographs of 103 patients (47%). Irradiation changes were found in 51 patients (23%); in 28 patients (13%) there were pulmonary metastases; and eleven patients had metastases of bony thoracic cage. 36% of patients with metastases had no symptoms. In eight patients other unexpected findings were observed, such as tuberculosis and sarcoidosis. Obviously, periodical chest radiographs are beneficial and advisable in the follow-up of patients with carcinoma of the breast.
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PMID:Value of chest radiography in follow-up of treated breast carcinoma. 378 55

A retrospective study was undertaken of 1005 normal contrast-enhanced head computed tomographic (CT) scans in children to determine normal standards for pituitary stalk diameter, basilar artery diameter, and their ratio for age and gender. The pituitary stalk enlarges with age, and girls have larger stalks than do boys after age 8. The pituitary stalk-to-basilar artery ratio is easily estimated visually. Ratios greater than or equal to 1 are unusual in normal children. A ratio greater than or equal to 1 should prompt direct measurement of the stalk and comparison with age-matched normal values. If the stalk measurement is greater than 2 SD above the age-matched mean, it is presumably abnormal and deserves further evaluation for numerous possible pathologic conditions including histiocytosis X, pituitary adenoma, hypothalamic lesions, Rathke cleft cysts, metastases, sarcoidosis, hypothyroidism, and infection.
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PMID:Normal pituitary stalk size in children: CT study. 387 41

Fifteen cases of multinodular lesions of the salivary glands are presented. All nodules were hypoechoic, the largest measuring over 5 mm. The various etiologies represented included: 8 non-Hodgkin's lymphomas, 5 metastases of cancer of the tongue, 1 sarcoidosis limited to the submaxillary gland, and 1 case of oncocytosis involving all four salivary glands. After discussing the rarity and the general characteristics of these lesions, the authors propose a diagnostic strategy following examination by ultrasound.
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PMID:Comparison of ultrasonographic and histological findings for multinodular lesions of the salivary glands. 391 Apr 33

Bilateral hilar lymphadenopathy developed in a patient one year after excision of a malignant melanoma of the left arm. There were no signs of distant metastases. Hilar lymph node biopsy specimen obtained by mediastinoscopy showed multiple noncaseating granulomas consistent with sarcoidosis, without evidence of tumor cells. Sarcoidosis developing in the course of a preexisting neoplasm is rare, but must be considered in order to establish a proper diagnosis and withhold unnecessary treatment.
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PMID:Sarcoidosis: a cause of bilateral hilar lymphadenopathy after excision of malignant melanoma of the arm. 403 44

A 59-years old woman showed 5 years after the diagnosis of a sarcoidosis of stage II--III according to Wurm and Reindell an abdominal symptomatology in the sense of an ulcerous disease. Radiological, endoscopical and bioptical examinations revealed a small contraction of the antrum, an ulcus at first diagnosed as benign and an adenocarcinoma. In the resected part of the stomach were found noncaseating granulomas with Epithelioid cells and Giant cells as well as the adenocarcinoma. 1 1/2 years after partial resection of the stomach (B II) a recurrence of the carcinoma near the anastomosis and metastases in the lymphonoduli of the abdomen were found by autopsy. Thoracic of abdominal manifestations of the sarcoidosis could no longer be demonstrated.
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PMID:[Sarcoidosis involvement and adenocarcinoma of the stomach]. 409 50


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