Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of metastatic malignant melanoma to the shaft of the penis is described and the literature reviewed to collate the incidence of primary sites which metastasize to the penis. Less than 260 cases of metastasis to the penis have been reported. Of these, 76% are from genitourinary primary sites and 17% are from gastrointestinal primary sites but only one case of metastatic melanoma to the penis has been previously reported. The described case presented with painful priapism while receiving combination chemotherapy for metastatic disease. A CT scan demonstrated a deposit in the left corpora cavernosa and needle aspiration cytology of a plaque attached to the shaft confirmed malignant melanoma cells. Palliation of the painful priapism was achieved by treatment with radiotherapy using large doses per fraction. Retrograde venous or lymphatic spread may have been the cause of a metastasis at this site. Prognosis is very poor.
 ...
PMID:Metastasis to the penis from malignant melanoma: case report and review of the literature. 137 19

Metastases to the penis from renal cell carcinoma producing priapism are very rare, as only 18 cases have been described since 1964. We present an additional case of priapism due to massive metastatic involvement of the corpora cavernosa in a patient with huge renal cell carcinoma, 28 cm in diameter, discussing the possible pathogenetic mechanism of such a rare condition.
 ...
PMID:Malignant priapism due to a huge renal carcinoma. 149 19

Penile metastases are uncommon lesions: most often secondary to a primary pelvic cancer (prostate, bladder and rectum) they have a unfavourable prognosis. The appearance of disseminations is still controversial and there is not an efficacious therapy. Priapism may be present or not. The Authors report their experience on a penile metastasis secondary to prostatic cancer and about the evolution of this pathology. A review of the Literature is done.
 ...
PMID:[Penile metastasis of prostatic carcinoma: a case report]. 183 Apr 11

Prostatic carcinoma metastatic to the penis is a rare phenomenon. We report two cases of acute urinary retention due to penile metastases from a prostatic carcinoma. Patients may have a penile mass or diffuse swelling of the penis. Some patients develop priapism and urinary retention can be rarely observed. The most effective treatment seems to be local excision with wide resection and, if necessary, total penectomy. The prognosis remains poor regardless of the type of therapy employed.
 ...
PMID:[Acute urinary retention secondary to cavernous metastases from a prostatic tumor]. 184 36

Solitary parenchymal metastases of renal cell carcinoma to the penis or testis are rare. We report 1 case of each: in one instance the patient presented with priapism and an asymptomatic primary tumor; in the other, the metastasis presented as an acute change in a long-standing hydrocele more than one year after nephrectomy. Both patients had either positive margins at resection or recurrence after resection of the metastasis. While long-term, disease-free survival has been reported after orchiectomy for isolated metastatic disease, penile involvement appears to carry a very poor prognosis.
 ...
PMID:Renal cell carcinoma involving penis and testis: unusual initial presentations of metastatic disease. 201 5

Prostatic carcinoma metastasising to the penis is a rare occurrence with only 56 cases reported in the literature. The incidence of transitional cell carcinoma arising primarily in the prostate ranges from 1. 5 to 4%. These tumors have uniformly poor prognosis regardless the type of therapy. Most of the patients die within two to six moths and very few survive beyond twelve months. A case of transitional cell carcinoma of the prostate with penile metastases and priapism is presented.
 ...
PMID:Transitional cell carcinoma of the prostate metastatic to penis as cause of priapism. 236 66

Penile metastases are uncommon lesions. They are most often secondary to a primary pelvic cancer (bladder, prostate, rectum). The appearance of a penile lesion may differ; priapism may or may not be present. The mode of dissemination is still controversial. The authors report one case and review the literature on penile metastases secondary to prostatic cancer. The essential point of their observations is the prolonged survival of their patient (7 years) whereas in the literature, the prognosis of these lesions is a rapidly fatal outcome.
 ...
PMID:[Penile metastasis of a prostatic neoplasm. Apropos of a case. Long-term survival]. 307 60

Priapism, the persistent painful erection unrelated to sexual stimuli, is called malignant whenever the priapism is due to metastases. A new case of malignant priapism, secondary to metastases of prostatic carcinoma is presented. As usual, survival was poor--our patient died 3 months after diagnosis was established.
 ...
PMID:Malignant priapism. 408 37

We report a clinical case of carcinoma of the rectum. A 45-year-old patient had undergone resection of the rectum and proctostomy 22 months ago. Carcinoma caused metastasis to the corpora cavernosa of the penis in this patient, and caused local recurrence of the carcinoma of the rectum, pulmonary metastasis and malignant priapism. A statistical analysis of 62 cases of secondary tumor of the penis in Japan was also made. The present clinical case was the 62nd case of secondary tumor of the penis in Japan, and the 4th case of secondary penile tumor from the rectum. The primary foci of the secondary tumor of the penis are mostly in the urinary bladder and the prostate, followed by the rectum, kidney, pelvis of the kidney and the ureter. Primary sites in the urogenital organs were found in 82.3% and in the neighboring organs in 85.2%. As the route of metastasis of the secondary tumor of the penis, arterial blood, retrovenous, retro-lymph and direct infiltrating metastasis may be possible. Secondary tumor of the penis is mostly found in aged persons, and the major symptoms may be penile nodule and mass, malignant priapism, penile pain and tenderness, and difficulty in urination and retention of urine. Regardless of the length to metastasis and difference in the treatment of the metastatic focus, the secondary tumor of the penis is poor in prognosis, and survival period may be up to 7 months. From the findings of post-mortem examination, secondary tumor of the penis should be regarded as a secondary sign due to recurrence of the primary tumor or presence of metastasis in other organs, and careless surgical operation should be avoided.
 ...
PMID:[A clinical case of secondary tumor of the penis from the rectum, with malignant priapism]. 674 57

Metastatic carcinoma of the penis is distinctly uncommon and in 80 percent of cases is associated with primary malignancy of the pelvic organs with widespread metastases. Pain and priapism are the most common symptoms at the time of the diagnosis. Both cases presented in this paper responded well to local irradiation, subjectively as well as objectively.
 ...
PMID:Metastatic carcinoma of the penis. 737 67


1 2 3 4 5 Next >>