Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Management of minor salivary gland adenoid cystic carcinoma is a controversial problem. Few clinicians obtain adequate experience in the treatment of this disease, which is often frustrated by early and late distant metastases. Fourteen cases of minor salivary gland adenoid cystic carcinoma recorded in the Delaware Registry over a 20-year period (1968 to 1988) were reviewed retrospectively. These cases were evaluated for their duration of symptoms; size, location, and histologic subtype of the lesion; perineural invasion; lymph node metastases; and treatment to determine the relationship of these factors to survival. Location and histologic subtype of the lesion and duration of symptoms were found to have a more significant impact on survival than size of the lesion, perineural invasion, or lymph node metastases. Surgery is the mainstay of therapy for minor salivary gland adenoid cystic carcinoma, with resection that includes disease-free margins but spares function being advocated. Although adjunctive radiation therapy has not been shown to increase survival, it is reasonable in lesions with perineural invasion and/or lymph node metastases.
Ear Nose Throat J 1991 Apr
PMID:Adenoid cystic carcinoma of the minor salivary glands. 165 39

Eight cases of primary adenocarcinoma of the nasal cavity associated with wood dust exposure are reported. The patients include seven men and one woman between the ages of 31 and 81 years. All the patients had a history of wood dust exposure. Carpentry was the occupation in four patients; inspector for railroad boxcars in one; teacher in a wood-work shop in another and worker in a desk factory in the other. The only female patient was a school teacher whose husband had a wood-work shop at home. Clinically, epistaxis and/or nasal obstruction were the most common symptoms. The histology of the tumors varied and consisted of well differentiated adenocarcinoma, clear cell adenocarcinoma, papillary-mucinous adenocarcinoma, and "colonic-type" adenocarcinoma. Follow-up data showed that three patients were alive of whom two had either recurrent or metastatic disease at one and three years following the initial diagnosis, respectively. The third patient was alive and well four years after initial diagnosis. Three other patients died but a direct cause of death was not identified. The remaining two patients were lost to follow-up.
Ear Nose Throat J 1991 Dec
PMID:Primary adenocarcinoma of the nasal cavity and paranasal sinuses. 181 30

NPC is unique among head and neck cancers, in that it is radiocurable and moderately chemosensitive. Modern diagnostic techniques have facilitated tumor definition, with consequent improvement in staging accuracy and radiotherapy planning. Our standard radiotherapy technique incorporates routine prophylactic neck irradiation of early tumors. Special techniques for more advanced tumors are described. Neoadjuvant cis-platinum-containing chemotherapy has proved useful in controlling regional and distant metastatic disease.
Ear Nose Throat J 1990 Apr
PMID:Radiotherapy and chemotherapy for nasopharyngeal carcinoma. 235 Oct 87

Although medullary carcinoma of the thyroid is rare, this disease generates considerable interest due to its unusual cellular origin from parafollicular C cells, ability to secrete calcitonin, and association with other endocrine adenomatosis. Pentagastrin-calcium stimulation continues to be the most valuable test for early diagnosis, in detecting recurrence of tumor, and for screening of family members. Total thyroidectomy along with central neck dissection is the treatment of choice. However, management of metastatic disease in the lateral neck remains controversial. We report three cases of medullary carcinoma of the thyroid to illustrate its various forms and the use of diagnostic tests.
Ear Nose Throat J 1989 Jan
PMID:Variable presentations of medullary carcinoma of the thyroid gland. 265 30

It can be agreed that up to 90% of patients with well-differentiated thyroid carcinomas have occult cervical disease; however, the biologic and prognostic implications of that prevalence remain debatable. Thyroid suppression therapy is supported, but I131 treatment is recommended only for manifest distant metastases or extracapsular invasion by the primary tumor--not for occult cervical disease alone. A cervical central compartment block resection, consisting of an extended glandular-primary tumor excision that includes adjacent node-bearing soft tissue between the jugular veins, below the hyoid, and into the superior mediastinum, appears to be the best treatment for the primary tumor and occult regional metastases. This resection can be done through a single low, transverse incision, leaving the sternocleidomastoid muscle, the accessory nerve, and submandibular triangle intact, yet better clearing the primary source and the high-risk nodes in the parathyroid area. The rationale for this degree of resection is based on (1) the high risk of central neck recurrences and (2) the fact that the superior mediastinal nodal metastases may become extensive or inoperable before they are detectable and are the most likely nodes in which metastases may result in death. Delayed manifestations of other laterally placed occult cervical nodes can be treated by conservative neck dissection at the time of their appearance, without a worsening of the prognosis.
Ear Nose Throat J 1989 Mar
PMID:Management of occult metastatic cervical disease from well-differentiated thyroid carcinoma. 266 26

Metastatic tumors to the head from infraclavicular primaries are relatively uncommon. The vast majority of primary tumors that metastasize to the head originate from the lung and breast. Tumors metastatic to the masseter are exceedingly rare with only one other case being reported in the literature. The case of a 34-year-old woman with a history of surgically-treated small cell carcinoma of the uterine cervix is presented. This case and our review of the literature illustrates the unusual nature of metastatic patterns in the head and their diagnostic complexity. Masses localized to the buccomasseteric region are usually considered to be of parotid origin. The differential diagnosis for masses in this area is generally limited to cogenital, inflammatory, or neoplastic lesions. Though uncommon, metastatic tumors from non-head and neck primary malignancies should be considered in the diagnosis as they may herald the onset of a new disease or the recurrence of cancer.
Ear Nose Throat J 1995 Feb
PMID:Metastatic small cell carcinoma to the masseter muscle originating from the uterine cervix. 770 30

Among twenty-six "undifferentiated" tumors of the nasal cavity and paranasal sinuses treated from 1970 to 1990 at the Institute of Otolaryngology of Florence University, 13 were ultimately diagnosed as true undifferentiated sinusonasal carcinoma (SNUC) by conventional light microscopy and use of monoclonal antibodies to epithelial membrane antigen and cytokeratins. SNUC patients, who ranged in age from 20 to 82 years, often had multiple sinonasal symptoms due to very large tumors (nine of 13 tumors were staged as T3-T4) with short average delay of 4 months between onset of symptoms and diagnosis. Both data suggest the high growth capacity and aggressiveness of such a tumor. In our series, follow-up evidenced an overall crude 5-year survival rate of 15.5%. Worse prognostic factors are neck metastases and orbital invasion, according to the behavior of more common carcinomas of the nose and paranasal sinuses. We also found a better prognosis for SNUC primarily arisen in the nasal cavity than in paranasal sinuses (crude 5-year survival rate of 66% vs. 10%, respectively). The histopathological and clinical analysis of our series shows that SNUC is a highly aggressive, uncommon tumor of the nose paranasal sinuses, which should be recognized in advance for a more aggressive treatment by combined multiple therapy.
Ear Nose Throat J 1993 Sep
PMID:Undifferentiated carcinoma of the nose and paranasal sinuses. An immunohistochemical and clinical study. 822 88

Patients expectorating blood seek evaluation and treatment from a variety of clinicians. Although the bleeding may arise either from the lungs (hemoptysis) or from the upper aerodigestive tract (pseudohemoptysis), the evaluation commonly focuses on exclusion of a pulmonary neoplastic source. Likewise, most literary reviews only focus on hemoptysis as it relates to pulmonary malignancies. The present retrospective review identifies 471 patients with the diagnosis of hemoptysis over a six-year period, and 10% were ultimately found to have UAT etiologies for their bleeding. UAT cancers were identified as the source in 2.1% of all patients, either due to primary lesions or via metastases. The majority of UAT cancers had been previously diagnosed prior to this episode of hemoptysis. This review indicates that a thorough UAT history and exam is warranted in the hemoptysis patient because of the significant occurrence of UAT causes. However, the likelihood of finding an occult UAT cancer in this patient population is very low with the only risk factor being a previous history of a UAT neoplasm.
Ear Nose Throat J 1995 Dec
PMID:Hemoptysis and pseudohemoptysis: the patient expectorating blood. 855 82

Malignant clear cell tumors of the head and neck are uncommon. Primary tumors may arise from the salivary glands, thyroid gland, or parathyroid glands, while metastatic tumors most commonly arise from the lungs, kidneys, and female genital tract. Renal cell carcinoma is the third most common metastatic tumor to the bone and soft tissues of the head and neck. Despite this, there have been few reported cases of renal clear cell carcinoma metastases to the neck. Here we report a unique case of an otherwise asymptomatic young woman with a left neck mass as the first clinical sign of advanced renal clear cell carcinoma.
Ear Nose Throat J 1996 Sep
PMID:Renal clear cell carcinoma appearing as a left neck mass. 887 Mar 69

Schwannomas (neurilemmomas) are neurogenic tumors that arise from the Schwann cells of the neural sheath. They are most often benign and solitary. Extracranial schwannomas are rare, and can be mistaken for metastatic disease or other non-neurogenic tumors. Ancient schwannoma is a rare variant of schwannoma with a course typical of a slow-growing benign tumor. Histologically, it can be confused with a malignant mesenchymal tumor. An unusual case of an ancient schwannoma of the submandibular gland is reported. The clinical, histological and surgical aspects of this tumor are discussed, and the literature regarding this rare entity is reviewed.
Ear Nose Throat J 1996 Dec
PMID:Ancient schwannoma of the submandibular gland: a case report. 899 Dec 27


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